The pathophysiologic characteristics of colorectal cancer in association with the lipid and carbohydrate metabolism disorders

Objective. To study the effect of carbohydrate and fat metabolism disorders оп the colorectal cancer. Materials and methods. The analysis of 3 groups of patients with colorectal cancer was performed: the first group normal BMI (20-24,99 kg/m 2) 139 patients, the second group overweight BMI (25-29,99 kg/m 2) 124 patients, the third group of obese patients (BMI 30 kg/m 2 or more) 78 subjects. The same analysis was performed among 3 groups of patients with colorectal cancer depending on the degree of carbohydrate metabolism disorders: 149 patients with a normal blood glucose level; 105 patients who had impaired glucose tolerance; 60 patients with a diagnosis of type 2 diabetes. We have estimated the effect of disturbances in lipid and carbohydrate metabolism in the nature of the colorectal cancer (multicentric and primary multiplicity) and metastasizing. Main results. Patients with type 2 diabetes are characterized by an increase in the proportion of multicentric lesions and primary multiplicity, while the risk of distant metastases is reduced. Obesity increases the proportion of multicentric lesions and the proportion of primary multiplicity, as well as the risk of distant metastases. Conclusion. The increase of the degree of lipid metabolism disturbance is directly proportional to the progression risk of colorectal cancer and worsening the disease prognosis, whereas the carbohydrate metabolism imbalance is not directly associated with the progression of colorectal cancer.