Polymorphisms of the genes of the serotonin receptor HTR2A, of tryptophan pyrrolase TDO2, the level of serotonin and psychological traits in the natives with alcoholism of the Republic of Sakha (Yakutia)

The contents of serotonin in peripheral venous blood of the indigenous people of the Arctic and subarctic zones of the Republic of Sakha (Yakutia) aged 21-68 years are studied and compared with the analysis results of single nucleotide polymorphism rs 6311 HTR2A serotonin receptor gene and the tryptophan 2,3-dioxygenase (tryptophan pyrrolase) TDO2 association with the alcoholism and psychological traits. Results. It is found that the surveyed persons from the Arctic zone of the Republic of Sakha (Yakutia) have concentration of serotonin in the physiological range, but the average level of the test amine is lower in the inhabitants of the subarctic zone in winter. Polymorphism A>C (rs 2271537) in the gene for tryptophan 2,3-dioxygenase (tryptophan pyrrolase) TDO2 in patients with alcohol dependence of Yakut and Even nationalities from subarctic zone of the Republic of Sakha (Yakutia) by polymerase chain reaction of DNA synthesis is performed. It is found that the frequency distribution of genotypes and alleles of the gene in populations TDO2 of Yakuts and Evens is not significantly different. A significant correlation of the genotype T/T gene HTR2A with low levels of serotonin is revealed, which reaches an average of 43,8±62,0 ng/ml. Psychological studies reveal hostility in 57.6% of those examined with the genotype A/C of the TDO2 gene (p=0.003). In women of the subarctic zone with genotype C/C rs 6311 of the HTR2A gene with a decreased serotonin level, in most cases aggressiveness is absent or diagnosed within the normal range (p=0.03).