Trying to optimize the timing of reconstruction of gastrointestinal tract, on the example of early closure of the ileostomy in patients with rectal cancer. Randomized multicenter study

Aims: assessment of the safety of early closure of temporary ileostomy in patients with rectal cancer after the total end partial mesorectal excision.Materials and methods: participants: patients of our clinical centers were examined with CT-proctography or rectoscopy to check whether bowel anastomoses were intact on 8-th day after the primary surgery. Patients with intact anastomoses who fulfilled the inclusion criteria were randomized to 2 groups: the first group, (n=37) with early closure of ileostomy (day 8-13 after stoma formation) and the second group (n=39) with deferred closure (after 12 weeks). It was expected that early closure would be a safe procedure.Results: 76 participants were randomized; results of their treatment were analyzed. Time boards of reconstructive surgery do not result in terms of postoperative complications (8.1% in 1-st group versus 7.7% in control, p=0,08, not significant). However duration of reconstructive surgery in the group with the early closure of ileostomy was shorter (Tm in 1-st group = 51 min (28-127) versus 70 min (30-135) in second group, duration of surgery in intervention group was shorter in 1,37 times that one in control group (95% CI 1,28-1,46, p=0,02))...