Antitumor effect of metallic nanoparticles (experimental study)

The experimental study of the effect of metallic nanoparticles (Zn, Cu, Fe and their alloy) on tumor growth in mice was carried out. Two transplanted tumors were studied: ascitic sarcoma 37 and solid sarcoma 180. Nanoparticles (NP) were administrated intratumorally, the total dose was 20 μg per mouse. The control groups were injected with isotonic NaCl. Dynamics of tumor growth, the state of tumor cells, survival and life-span of mice were assessed. We found that NP possess substantial antitumor effect, causing tumor regression up to the complete one, inducing the damage of tumor cells and increase of animals` life-span without any visible signs of toxicity.