Early diagnosis of bone-cartilaginous changes in osteoarthritis (literature review)

The aim of the study is to identify the most significant biomarkers in the diagnosis of early changes in bone and cartilage structures.Materials and methods. In the course of the work, a review of modern foreign literature over the past 5 years was conducted, in which studies of biochemical markers for early diagnosis of changes in bone and cartilage tissue were conducted, using the capabilities of the Internet resources PubMed, Elibrary, Cyberleninka.Results. The basic markers indicating the formation of changes in bone and cartilage tissue were identified, as well as specific ones - characteristic of a particular pathology. The degree of their specificity for diagnosis has been studied.Therefore: the search, identification and study of new biochemical markers for early diagnosis of pathology of the bone-cartilage system is an urgent task.