Regression analysis of survival in patients with nodal non-Hodgkin's lymphomas of abdominal and pelvic localization

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The study assessed the influence of 21 factors characterizing the influence of the parameters of the patient, the disease and the treatment on overall survival and progression-free survival using univariate and multifactorial Cox regression analysis in 208 primary patients with nodal non- Hodgkin's lymphomas of the abdominal cavity or pelvis who received chemotherapy or chemoradiotherapy. In a one-factor regression analysis, 18 factors significantly affected overall survival: age, Ann Arbor stage, Ann Arbor stage category (1-2 or 3-4), international prognostic index, Karnovsky index, total number of affected areas, number of massively affected lymphatic zones, localization of the primary focus, maximum tumor size before the onset treatment, the maximum size of the tumor after chemotherapy, the maximum size of the tumor after radiation therapy, the number of cycles of chemotherapy, the number of injections of Rituximab, the immediate effect of chemotherapy, total focal dose during radiation therapy, immediate effect of treatment, treatment program (chemoradiotherapy vs. chemotherapy). Multivariate regression analysis determined the prognostic model of 7 factors (Karnovsky index, disease stage, number of massively affected lymphatic zones, maximum tumor size after chemotherapy, the number of injections of rituximab, the immediate effect of treatment (complete remission vs partial remission / stabilization), treatment program), which allows to compare the overall survival graphs of the patient after chemotherapy and chemoradiotherapy with a high degree of statistical significance (Chi-squared = 87.2298, P = 0.00000).Similarly, a prognostic model of 5 factors was determined (the number of affected lymphatic zones, the number of injections of rituximab, the maximum tumor size after chemotherapy, the immediate effect of treatment, the treatment program), which also allows to compare the survival without progression graphs of the patient after chemotherapy and chemoradiotherapy with a high degree of statistical significance (Chi-squared = 71.5326, P = 0.00000). Comparison of the numerical values of 5-year and 10-year survival are the basis for determining the feasibility of adjuvant radiation therapy in the particular patient.

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Abdominal and pelvic nodal non-hodgkin lymphomas, regression analysis, chemoradiotherapy, adjuvant radiation therapy, rituximab, overall survival, progression-free survival

Короткий адрес: https://sciup.org/149142066

IDR: 149142066

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