Systemic AA-amyloidosis: modern aspects of diagnosis and treatment, influence on the course of oncohematological diseases

Systemic AA-amyloidosis is a rare secondary disease that develops due to chronic inflammation and is characterized by the deposition of fibrillar glycoprotein amyloid in the extracellular matrix of tissues and organs, which disrupts their normal architecture and function. Starting treatment on time can stop the progression of the condition, however, complete regression of amyloid masses is not possible at the present stage of treatment development. Therefore, early diagnosis of AA-amyloidosis is especially important, but it is associated with a number of difficulties due to the lack of pathognomonic clinical signs. A rare and poorly studied cause of AA-amyloidosis is a number of oncohematological diseases.