Screening is the first part in system of a breast examination

Purpose To define efficiency oncoepidemiological testing's (OET) in formation of group of risk of breast diseases at women and to reveal the most significant factors influencing development of breast diseases, depending on a background condition of a breast and age of the woman. Materials and methods. As a result of 20-years randomize cohort monitoring of 1500 women, on the basis of OET and маммографии (MG) the group of high risk of 570/1500 women (38 %) on breast diseases and group of low risk of 930/1500 women has been allocated. Group of the control - 120/930 women (13 %) without risk factors and changes of a breast and current of 20 years. Results. Combination OET and MG has raised revealing breast cancer (BC) in group of high risk at screening in 5 times and at monitoring in 10 times, has increased revealing patients in stage Т0-1N0M0 up to 70±1 %, has defined age of the beginning regular mammography inspections (40 years) and intervals between rounds (1 year in group of risk). The decision of a question on medical tactics was carried out depending on the revealed risk factors and results of consultation of experts of related subjects (the gynecologist-endocrinologist, medical genetic, the oncologist - mammologist, the surgeon). At BC till 40 years the first place borrowed reproductive infringements 93 %: from them childbirth after 30 years 43%, early till 13 years the beginning of menstrual cycle and gynecologic diseases - 21%, absence of pregnancy - 14%. Genetic risk of cancer 67 %: breast cancer at line of mother - 40 % both a cancer of a lung and a cancer of a stomach on a line of the father - 27 %; сchronic psychoemoutional overloads 58 %, traumas of a breast 21%; excess weight 27%. Conclusions. On our data method OET of women in the 20 - 40 ages allows to narrow a circle of persons of subjects up to 38 % and to allocate the group of high risk demanding the annual control and defines the program of the further actions.