A combination of Gilbert’s syndrome and primary sclerosing cholangitis

The article describes the pathological increase in bilirubin levels in the blood (hyperbilirubinemia), which provides grounds for discussing liver dysfunction. A clinical case of a patient with a combination of two conditions manifesting as jaundice, primary sclerosing cholangitis and Gilbert's syndrome, is discussed. This case demonstrates the complexity of diagnosing diseases that present with jaundice and the need for thorough patient history collection and detailed examination. Diagnosis required the use of genetic testing for UGT1A1 gene mutations, magnetic resonance cholangiopancreatography, and serological blood analysis for p-ANCA antibodies. Despite having different etiopathogenetic mechanisms, it is important to consider the combination of Gilbert's syndrome and primary sclerosing cholangitis for effective patient management and reducing the risk of adverse outcomes. It is also important to consider the complexity of diagnosing diseases that present with hyperbilirubinemia, as well as the possibility of different diseases occurring together.