Современные возможности безопиоидного послеоперационного обезболивания

Автор: Ефременко Ирина Валерьевна, Овечкин Алексей Михайлович

Журнал: Хирургическая практика @spractice

Статья в выпуске: 1, 2013 года.

Бесплатный доступ

Состояние послеоперационного обезболивания продолжает оставаться неудовлетворительным во всем мире. Возможности применения опиоидных анальгетиков во многом исчерпаны, сопряжены с рядом осложнений, кроме того, жестко регламентированы законами Российской Федерации. Препараты группы НПВС имеют серьезные противопоказаний со стороны ряда пациентов. В связи с этим, особый интерес представляют средства, воздействующие на ^метил-Б-аспартат ионные рецепторы, играющие важную роль в механизмах формирования острой боли. В данном обзоре рассматривается эффективность применения микродоз кетамина, антиковульсанта габапентина, а также сульфата магния в схемах послеоперационного обезболивания.

Еще

Послеоперационное обезболивание, nmda-рецепторы, вторичная гиперальгезия, кетамин, габапентин, сульфат магния

Короткий адрес: https://sciup.org/142211501

IDR: 142211501

Список литературы Современные возможности безопиоидного послеоперационного обезболивания

Apfelbaum J., Chen C., Mehta S. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged//Anesth. Analg. 2003. Vol. 97. P. 534-540.
Argiriadou H., Himmelseher S., Papagiannopopulou P. Improvement of pain treatment after major abdominal surgery by intravenous S(+) ketamine//Anesth. Analg. 2004. Vol. 98. P. 14131418.
Benhamou D., Berti M., Brodner G. Postoperative analgesic therapy observational survey (PATHOS): a practice pattern study in 7 central/southern European countries//Pain. 2008. Vol. 136. P. 134-141.
Brogly N., Wattier J-M., Andrieu G. Gabapentin attenuates late but not early postoperative pain after thyroidectomy with superficial cervical plexus block//Anesth. Analg. 2008. Vol. 107. P. 1720-1725.
Clivatti J., Sakata R., Issy A. Review of the use of gabapentin in the control of postoperative pain. Rev.Bras.Anesthesiol. 2009;.59:.87-98.
Dahl J., Mathiesen O., Moniche S. Protective premedication: an option with gabapentin and related drugs. A review of gabapentin and pregabalin in the treatment of postoperative pain//Acta Anaesth. Scand. 2004. Vol. 48. P. 1130-1136.
De Kock M., Lavand'homme P., Waterloos H. Balanced analgesia in the perioperative period: is there place for ketamine?//Pain. 2001. Vol. 92. P. 373-380.
Dirks J., Fredensborg B., Christensen D. A randomizes study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy//Anesthesiology. 2002. Vol. 97. P. 560-564.
Dolin S., Cashman J., Bland J. Effectiveness of acute postoperative management. I. Evidence from published data//Br. J. Anaesth. 2002. P. 409-423.
Durieux M. Peripheral analgesic receptor system//Br. J. Anaesth. 2006. Vol. 97. P. 273-274.
Elstraete A., Tirault M., Lebrun T. The median effective dose of preemptive gabapentin on postoperative morphine consumption after posterior lumbar spinal fusion//Anesth. Analg. 2008. Vol. 106. P. 305-308.
Fassoulaki А., Patris K., Sarantopoulos C. The analgesic effect of gabapentin and mexiletine after breast surgery for cancer//Anesth. Analg. 2002. Vol. 95. P. 985-991.
Gilron I., Biederman J., Jhamandas K. Gabapentin blocks and reverses antinociceptive mor-phine tolerance in the rat paw-pressure and tail-flick tests//Anesthesiology. 2003. Vol. 98. P. 1288-1292.
Hahm T., Ahn H., Bae C-D. Protective effects of gabapentin on allodynia and a261-subunit of voltage-dependent calcium channel in spinal nerve-ligated rats//J. Korean Med. Sci. 2009. Vol. 24. P. 146-151.
Kehlet H., Rung G., Callesen T. Postoperative opioid analgesia: time for a reconsideration?//J. Clin. Anaesth. 1996. Vol. 8. P. 441-445.
Kehlet H., Holte K. Effect of postoperative analgesia on surgical outcome//Br. J. Anaesth. 2006. Vol. 87. P. 62-72.
Lavand'homme P., De Kock M., Waterloos H. Intraoperative epidural analgesia combined with ketamine provides effective preventive analgesia in patients undergoing major digestive surgery//Anesthesiology. 2005. Vol. 103. P. 813-820.
Laulin J.-P., Maurette P., Rivat C. The role of ketamine in preventing fentanyl-unduced hy-peralgesia and subsequent acute morphine tolerance//Anesth. Analg. 2002. Vol. 94. P. 1263-1269.
Maier C., Nestler N., Richter H. The quality of postoperative pain management in German hospitals//Dtsch. Arstebl. Int. 2010. Vol. 107. P. 607-614.
Mao J., Price D., Mayer D. Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible mechanisms//Pain. 1995. Vol. 62. P. 259-274.
McCartney C., Sinha A., Katz J. A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia//Anesth. Analg. 2004. Vol. 98. P. 1385-1400.
Oderda G., Evans S., Lloyd J. Cost of opioid-related adverse drug events in surgical pa-tients//J. Pain Symptom Manage. 2003. Vol. 25. P. 276-283.
Pandey C., Navkar D., Giri P. Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized double-blind placebo-controlled study//J. Neurosurg. Anesthesiol. 2005. Vol. 17. P. 65-68.
Peng P., Wijeysundera D., Li C. Use of gabapentin for perioperative pain control -a meta-analysis//Pain Res. Manage. 2007. Vol. 12. P. 85-92.
Polomano R., Rathmell J., Krenzischer D. Emerging trends and new approaches to acute pain management//Pain Management Nursing. 2008. Vol. 9. P. 33-41.
Rowbotham W. Gabapentin: a new drug for postoperative pain?//Br. J. Anaesth. 2006. Vol. 96. P. 152-155.
Stubhaug A., Breivik H., Eide P. Mapping of punctuate hyperalgesia around a surgical inci-sion demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery//Acta Anaesth. Scand. 1997. Vol. 41. P. 1124-1132.
Subramaniam K., Subramaniam B., Steinbrook R. Ketamine as adjuvant analgesic to opioids: a quantitative an qualitative systematic review//Anesth. Analg. 2004. Vol. 99. P. 482-495.
Suzuki M., Haraguti S., Sugimoto K. Low-dose intravenous ketamine potentiates epidural analgesia after thoracotomy//Anesthesiology. 2006. Vol. 105. P. 111-119.
Tiippana E., Hamunen K., Kontinen V. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety//Anesth. Analg. 2007. Vol. 104. P. 1545-1556.
Tramer M, Schneider J., Marti R., Rifat K. Role of magnesium sulfate in postoperative analgesia//Anesthesiology. 1996. Vol. 84. P. 340-347.
Tramer M., Glynn C. An evaluation of a single dose of magnesium to supplement analgesia following ambulatory surgery: randomized controlled trial//Anesth. Analg. 2007. Vol. 104. P. 1374-1379.
Turan A., Karamanlioglu B., Memeis D. Analgesic effect of gabapentin after spinal surgery//Anesthesiology. 2004. Vol. 100. P. 935-938.
Turan A., Kaya G., Karamanlioglu B. Effect of oral gabapentin on postoperative epidural analgesia//Br. J. Anaesth. 2006. Vol. 96. P. 242-246.
Urban M., Ya Deau J., Wukovits B. Ketamine as an adjunct to postoperative pain man-agement in opioid tolerant patients after spinal fusions: a prospective randomized trial//HSS J. 2008. Vol. 4. P. 62-65.
Weissberg N., Schwartz G., Shemesh O. Serum and intracellular electrolytes in patients with and without pain//Magnes. Res. 1991. Vol. 4. P. 49-50.
Weinbroum A. A single small dose of postoperative ketamine provides rapid and sustained improvement in morphine analgesia in the presence of morphine-resistant pain//Anesth. Analg. 2003. Vol. 96. P. 789-795.
Wheeler M., oderda G., Ashburn M. Adverse events associated with postoperative opiod analgesia: a systemic review//J. Pain. 2002. Vol. 3. P. 159-180.
Zarauza R., Saez-Fernandez A., Iribarren M. A comparative study with oral nifedipine, in-travenous nimodipine and magnesium sulfate in postoperative analgesia//Anesth. Analg. 2000. Vol. 91. P. 938-943.

Еще

Статья обзорная