Старение и омоложение резидентных стволовых клеток - новый путь к активному долголетию?
Автор: Баклаушев Владимир Павлович, Самойлова Екатерина Михайловна, Кальсин Владимир Анатольевич, Юсубалиева Гаухар Маратовна
Журнал: Клиническая практика @clinpractice
Рубрика: Обзоры
Статья в выпуске: 1 т.13, 2022 года.
Бесплатный доступ
В обзоре представлены современные данные о методологии оценки биологического и эпигенетического возраста; описана концепция эпигенетических часов; охарактеризованы основные виды резидентных стволовых клеток и особенности их старения. Показано, что возрастные изменения органов и тканей, а также ассоциированные с возрастом заболевания во многом обусловлены старением резидентных стволовых клеток. Последние представляют собой привлекательную мишень для клеточного омоложения, поскольку могут быть отобраны, культивированы ex vivo, модифицированы и вновь возвращены в резидентные ниши. Основные методологии клеточного омоложения включают генетическое репрограммирование с «обнулением» возраста клетки с помощью транзиторной экспрессии транскрипционных факторов, а также различные подходы к эпигенетическому омоложению, путем изменения генетической экспрессии про- и антивозрастных факторов, модулирования клеточного метаболизма. Тесная взаимосвязь старения, регенерации и онкогенеза между собой и с функционированием ниш резидентных стволовых клеток требует дальнейших прецизионных исследований, результатом которых, мы уверены, может стать создание эффективной стратегии антиэйджинга и продления активной жизни человека.
Резидентные стволовые клетки, старение, репрограммирование, омоложение, эпигенетические часы
Короткий адрес: https://sciup.org/143178548
IDR: 143178548
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