Study of effects of simulated space flight factors and use of infusion liquids on human hemodynamics with the use of the cardiocode method

Aims The aim is to study the effect of simulated space flight factors on the human central hemodynamics and evaluate the effectiveness of colloid and crystalloid infusions in microgravity simulation using the Cardiocode method. Materials and methods Test subjects were six men aged 20 to 35 without chronic somatic diseases. Antiorthostatic hypokinesia with an angle of 15 ° (ANOH-15) simulated the weightlessness was used. Diuretics were used to simulate hypovolemia in the test individuals. During ANOH-15 the colloid and crystalloid intravenous infusions were applied. Central hemodynamics parameters were measured by Cardiocode method. Results Background quantitative and qualitative central hemodynamics parameters were obtained, several individual characteristics of blood flow regulation were identified. The effects of space flight factors, ground-based simulated with antiorthostatic hypokinesia, on the human hemodynamics were investigated. The efficacy of crystalloid and colloid infusions for the correction of central hemodynamics abnormalities in test subjects with hypovolemia in microgravity was studied. Conclusion The Cardiocode method allowed obtaining the information about the effects of simulated space flight factors and different infusion fluids on the human central hemodynamics. The efficacy of crystalloid and colloid infusions for the correction of central hemodynamics abnormalities in test subjects in microgravity was positively evaluated.