Study of pharmacological activity of Glycyrrhiza glabra L
Автор: Ismayilov P., Mehtiyeva F.
Журнал: Бюллетень науки и практики @bulletennauki
Рубрика: Естественные науки
Статья в выпуске: 2 т.11, 2025 года.
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In article the results of overview research about pharmacological activity of Glycyrrhiza glabra L. is given. Liquorice (licorice) root is derived from the inner part of the root and underground stem (rhizome) of Glycyrrhiza glabra (Fabaceae, the bean family). The peeled drug is of much higher quality than the root with the bark, and is produced in several south-eastern European countries, Turkey, China and Russia. It has a very characteristic taste and smell, and is used in confectionery. The sweet taste also makes the identification of the drug relatively easy and so adulteration is uncommon. The most important bioactive secondary metabolite is glycyrrhizic acid, a water-soluble pentacyclic triterpene saponin which gives the drug its characteristic sweet taste (it is about 50 times sweeter than sucrose). Liquorice also contains numerous flavonoids (chalcones and isoflavonoids), coumarins and polysaccharides, which contribute to the activity.
Licorice, medicinal properties, glycyrrhizic acid
Короткий адрес: https://sciup.org/14132068
IDR: 14132068 | DOI: 10.33619/2414-2948/111/12
Список литературы Study of pharmacological activity of Glycyrrhiza glabra L
- Van Rossum, T. G., Vulto, A. G., Hop, W. C., & Schalm, S. W. (2001). Glycyrrhizin-induced reduction of ALT in European patients with chronichepatitis C. Am J Gastroenterol, 96, 2432-2437.
- Tsubota, A., Kumada, H., & Arase, Y. (1999). Combined ursodeoxycholic acid and glycyrrhizin therapy for chronichepatitis C virus infection: a randomized controlled trial in 170 patients. Eur J Gastroenterol Hepatol, 11, 1077-1083.
- Shirazi, M. H., Ranjbar, R., & Eshraghi, S. (2007). An evaluation of antibacterial activity of Glycyrrhiza glabra extract on the growth of Salmonella, Shigella and ETEC E. coli. Journal of Biological Sciences, 7, 827–829.
- Geetha, R. V., & Roy A. (2012). In-vitro evaluation of antibacterial activity of ethanolic root extract of Glycyrrhiza glabra on oral microbes. IJDDR, 4(4), 161–165.
- Trivedi, R, & Sharma, K. (2011). Hydroalcoholic Extract of Glycyrrhiza glabra Linn. Attentuates Chronic Fatigue Stress Induced Behavioral Alterations in Mice. International Journal of Pharmaceutical & Biological Archive, 2(3), 996–1001.
- Pompei, R., Pani, A., Flore, O., Marcialis, M. A., & Loddo, B. (1980). Antiviral activity of glycyrrhizic acid. Experientia, 36, 304. https://doi.org/10.1021/jm0493008
- Krausse, R, Bielenberg, J, Blaschek, W, & Ullmann, U. (2004). In antiHelicobacter pylori activity of Extractum liquiritiae glycyrrhizin and its metabolites. J Antimicrob Chemother, 54(1), 243-246.
- Karomatov, I., Rakhmatova, M., & Zhalolova, Z. (2020). Lekarstvennye rasteniya i medikamenty. Mauritius LAP LAMBERT Academic Publishing.
- Karomatov, I. D., & Abduvokhidov, A. T. (2018). Pobochnye effekty preparatov solodki (obzor literatury). Biologiya i integrativnaya meditsina, (8).
- Mamedov, N. A., & Egamberdieva, D. (2019). Phytochemical Constituents and Pharmacological Effects of Licorice: A Review. Plant Hum. Health, 3, 1–21.
- Hayashi, H., Yokoshima, K., Chiba, R., Fujii, I., Fattokhov, I., & Saidov, M. (2019). Field survey of Glycyrrhiza plants in Central Asia. Chemical characterization of G. bucharica Collected in Tajikistan. Chem. Pharm. Bull., 67, 534–539.
- Wahab, S., Annadurai, S., Abullais, S. S.. Das, G., Ahmad, W., Ahmad, M. F., Kandasamy, G., Vasudevan, R., Ali, M. S., & Amir, M. (2021). Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology. Plants, 10, 2751.
- Graebin, C. S. (2018). The Pharmacological Activities of Glycyrrhizinic Acid (“Glycyrrhizin”) and Glycyrrhetinic Acid. In Sweeteners, 245–261.
- Ahmed-Farid, O. A., Haredy, S. A., Niazy, R. M., Linhardt, R. J., & Warda, M. (2019). Dose-dependent neuroprotective effect of oriental phyto-derived glycyrrhizin on experimental neuroterminal norepinephrine depletion in a rat brain model. Chem.-Biol. Interact, 308, 279–287.
- Sharma, S., Chourasia, R., Pandey, A., Rai, A., & Sahoo, D. (2021). Alzheimer’s disease: Ethanobotanical studies. In Naturally Occurring Chemicals Against Alzheimer’s Disease, 1, 11–28.
- Wahab, S., Ahmad, I., Irfan, S., Siddiqua, A., Usmani, S., & Ahmad, M. P. (2022), Pharmacological Efficacy and Safety of Glycyrrhiza glabra in the treatment of respiratory tract infections. Mini-Rev. Med. Chem., 22, 1476–1494.
- Lanjekar, K. J., & Rathod, V. K. (2021). Green extraction of Glycyrrhizic acid from Glycyrrhiza glabra using choline chloride based natural deep eutectic solvents (NADESs). Process. Biochem., 102, 22–32.
- Hong, J. H., Jung, I. I., Cho, Y. K., Haam, S., Lee, S.-Y., Lim, G., & Ryu, J.-H. (2019). Preparation of High-quality Glabridin Extract from Glycyrrhiza glabra. Biotechnol. Bioprocess E, 24, 666–674.
- Chauhan, S., Gulati, N., & Nagaich, U. (2018). Glycyrrhizic acid: Extraction, screening and evaluation of anti-inflammatory property. Ars Pharm., 59, 61–67.
- Musayeva, S., Valiyeva, M., Madatli, F., Mehraliyeva, S., Khalilov, R., Vahedi, P., & Eftekhari, A. (2021). Prospects for the development of drugs with antiviral activity based on licorice. Eurasian Chem. Commun, 3, 301-309.
- Eivazly, S. (1998). Solodka — eto blagoslovenie, kotorym priroda odarila Azerbaidzhan. Baku. (in Azerbaijani).