The level of the brain-derived neurotrophic factor is reduced in the blood serum of patients with melancholic depression

Introduction. A comprehensive study of depression and pathogenetic mechanisms of this disease is one of the main tasks of medical science. The socio-demographic (old age, female gender, low social status, unemployment) and clinical (history of depressive symptoms, somatic and neurological diseases) risk factors for the development of depression are described. Manifestations of melancholy are often found in the structure of anxious depression. Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in depression.