Effect of Lophantus chinensis dry extract on psychoemotional state of Wistar rats with chronic toxic hepatitis

In the study we have accessed the effect of Lophanthus chinensis dry extract on the psychoemotional state of Wistar rats with chronic toxic hepatitis. Chronic toxic hepatitis was modeled by combined administration of carbon tetrachloride and ethanol. We assessed animal behavior using the open field and elevated plus maze tests. It was found that L. chinensis extract at a dose of 100 mg/kg reduces anxiety in animals with chronic hepatitis, increases exploratory activity, as evidenced by a decrease in the number of defecation and grooming acts on the back of increased entries into the central squares, stands without support in the open field, entries into the open space and the time spent there, as well as increased hangings and vertical stands in the elevated plus maze. Thus, L. chinensis dry extract due to its anxiolytic properties, improves the psychoemotional state in animals with сhronic liver disease.