The effect of undifferentiated connective tissue dysplasia on the clinical course of varicose disease and thrombophlebitis of varicose veins after crossectomy

Objective: to analyze the features of clinical course of lower extremity varicose vein disease and acute thrombophlebitis of varicose veins for the patients with undifferentiated connective tissue dysplasia after crossectomy. Material and methods. The prospective clinical cohort study covered 132 female patients with varicose disease who underwent crossectomy. 67 patients with dysplasia were included into the main group; patients without dysplasia were included into the control group. Examination of patients and ultrasound scanning of lower extremity veins were made in 3, 6, 12, 36 months. The Cox regression analysis was used to assess the influence of dysplasia on the risk of developing thrombophlebitis of varicose veins. Results. The progress of clinical manifestations of varicose disease after crossectomy was found for 57 (85.1 %) female patients with dysplasia and for 14 (21.5%) female patients without dysplasia (p=0.002), which needed making phlebectomy The recurrence of thrombophlebitis of varicose veins was found for 22 (32.8%) female patients with dysplasia and for 5 (7.7%) female patients without dysplasia (p=0.002). The indication of Cox-model Exp(S), which characterizes the predicted change of risks for dysplasia, was 4,216 (95% С11.595-11.147). Conclusion. The clinical course of varicose disease for patients with undifferentiated connective tissue dysplasia is characterized by the progression of clinical manifestations of chronic venous insufficiency of extremity. Undifferentiated connective tissue dysplasia increases the risk of developing the recurrence of thrombophlebitis of varicose veins after crossectomy by more than 4.2 times.