The effect of the volume of surgery on the results of treatment of infiltrating low-grade gliomas WHO Grade II, depending on a number of prognostic factors

Objectives. Study and analysis of the influence of the degree of primary tumor resection on the results of treatment of infiltrating low-grade gliomas WHO Grade II, depending on various prognostic factors Materials and methods. In total, 107 patients with morphologically verified infiltrative glioma of low grade WHO Grade II were included in the study. Morphological examination revealed 14 patients (13%) with oligoastrocytoma, 36 patients (34%) - with oligodendroglioma, and 57 patients (53%) - with diffuse astrocytoma. The average age of patients was 38.5 years. Non- progressive survival (progression-free survival, PFS) was under study. Results. In patients under 30 years old, radical surgery significantly improved PFS compared to non-radical surgery (test Log Rank p=0.058; test Breslow p=0,036; test Tarone-Ware p=0.037). Radical surgery did not differ by the indices of PFS in patients with diffuse astrocytoma and oligodendroglial tumors (test Log Rank p=0,964; test Breslow p=0,444; test Tarone-Ware p=0,653). Differences between the groups according the NCCN (National Comprehensive Cancer Network) prognostic criteria were significant (test Breslow p=0,015; test Tarone-Ware p=0,036). Conclusion. Within individual prognostic categories, the degree of surgical intervention affects PFS. The NCCN criteria have a high prognostic value for clinical practice.