The effect of primary and revision endoprosthetics on the immune system

The immunograms of patients with degenerative-and-dystrophic diseases of the hip (dysplastic, posttraumatic, rheumatoid coxarthrosis and aseptic necrosis of femoral head) have been analysed before endoprosthetics and in the dynamics after the surgery performed. It has been established, that there are serious disorders of the immune system in patients who visit a clinic for the purpose of revision endoprosthetics been performed. It is reflected by more marked T- and B-lymphopenia with more intensity of cellular immunity functional activity mostly at the expense of immature cortical thymocyte output. Significant disbalance of immunoregulatory subpopulations is noted in patients before endoprosthesis revision; and this disbalance is expressed as decreased content of helper cells and increased content of killer cells and suppressor cells.