Effect of the phytocompound canephron N on the efficacy of the extracorporeal shock-wave lithotripsy

Aim of the study: to investigate the effect of phytomedicine Canephron® N on the outcomes of the extracorporeal shockwave lithotripsy (ESWL). Materials and methods. This study was prospective and included randomization. Overall, 642 patients were included with ESWL using “Dornier Compact Delta II”. In the first group 320 patients received one day before the ESWL and 90 days thereafter Kanephron® N 2 dragees 3 times pro day. In the second group 322 patients did not receive Canephron® N. Results. In the first group 81.9% of patients were stone-free at day 5 after procedure (65.2% in control group), at day 90 - 93.1% of patients (78.3% in control group). In the second group complications arose in 17.1% of patients, including acute obstructive pyelonephritis (1.2%), steinstrasse in 2.2% and renal colic in 13.7% of patients. Mean hospitalization length was 9.8±0.8 days in the Group 2. In the Canephron® N group complications rate was 1.2% with mean hospitalization duration 6.0±0.5 days. The other putative effects of Canephron® N were increase in the dairy diuresis, stimulation of renal filtration, decrease in the severity of leukocyturia, bacteriuria and proteinuria, compared to the patients in group 2. Conclusions: Canephron® N could ameliorate the withdrawal of the stone fragments, decrease the complication rate after ESWL and hospitalization length. It could also reduce the recurrence rate.