Possibilities of functional MRI techniques in an efficiency estimation neoadjuvant chemoradiation therapy at patients with cervical cancer

Research objective was definition of dependence of apparent diffusion coefficient (ADC) and perfused properties of a tumor from influence neoadjuvant chemoradiation therapy (n-CRT) at patients with invasive cervical cancer. 43 patients with cervical cancer invasive forms are examinated, with stage T1b1-3bN0-1M0-1. Depending on effect have been divided in 2 groups: 34 patients with presence of a residual tumor and 9 cases with full resorption tumors. All MRI results have been compared with the data of postoperative histological research. In both groups of patients after n-CRT in a tumor levels of ADC and perfusions became higher. ADC in a residual tumor has on the average was 1.34 + 0.27 c/mm2 ∙10-3, at average value ADC in intact stroma 1.79 + 0.46 c/mm2 ∙ 10-3. The perfusion estimation didn't allow to carry out differential diagnostics between a residual tumor and reactive postradial changes.