Possibilities for improving the therapeutic activity of bacteriophage preparations

Автор: Perepanova T.S., Kazachenko A.V., Malova Yu.A., Khazan P.L., Nazirov M.R., Pseunova D.R., Apolikhin O.I., Kaprin A.D.

Журнал: Экспериментальная и клиническая урология @ecuro

Рубрика: Инфекционно-воспалительные заболевания

Статья в выпуске: 4 т.16, 2023 года.

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Introduction. Growth of urological infection caused by antibiotic-resistant pathogens require the search for alternative antimicrobial treatments. Bacteriophage (phage) preparations are currently the only viable alternative to antibiotics. The therapeutic effect of bacteriophages is significantly different from antibiotics, making them active against multidrug-resistant bacteria. Bacteriophage therapy creation of viral infection in bacteria. However, the effectiveness of treatment depends primarily on the quality of commercial bacteriophage preparations. The collections of bacteriophages is constantly updated in industrial production but in order to increase the lytic activity of bacteriophage preparations to the uropathogens of our clinic, it is necessary to constantly determine the sensitivity of the main pathogens of infection to commercial bacteriophage preparations and regularly update (adapting) commercial phage preparations.

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Antibiotic resistance, bacteriophage preparations, bacteriophage therapy of urological infection, improvement of the lytic activity of bacteriophage preparations

Короткий адрес: https://sciup.org/142240786

IDR: 142240786   |   DOI: 10.29188/2222-8543-2023-16-4-156-163

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