Level of exhaled nitric oxide and clinical course of bronchial asthma at pregnancy in the Amur region

Bronchial asthma (BA) is one of the most common diseases of pulmonary system. It occupies one of the leading places among the allergic diseases in pregnant women. The main aim of this research is to study clinical and epidemiological features of BA in pregnant women during the last 5 years and to determine the level of exhaled nitric oxide at different gestational age in patients with BA in the Amur region. Materials and Methods. During last five years a total of 86 pregnant women with BA were examined. Among them there were 41 patients with mild case of BA, 39 patients with moderate BA, and 6 patients with severe BA. An average disease lasted for 8.7±0.7 years. The level of exhaled nitric oxide was measured in each trimester of pregnancy using breathing apparatus NO Breath (Great Britain). Results. The result obtained show that the percentage of moderate and severe BA, mainly allergic form (pst trimester. It was connected with a shift of endocrine profile during pregnancy. NOex level increased at moderate and severe BA in the 2nd and 3rd trimesters. It may be related to spontaneous self-cessation of therapy during pregnancy. Continuous treatment by inhaled glucocorticosteroids reliably reduced NOex level in moderate and severe BA that led to decrease in BA attacks during pregnancy.