Clinical morphology of the algorithm for the diagnosis of pathological conditions observed in the respiratory organs in COVID 19

Coronavirus infection (COVID-19) is an acute infectious disease caused by SARS CoV-2 with an aerosol-drip and contact-household transmission mechanism. Pathogenetically, COVID-19 is characterized by viremia, local and systemic immuno-inflammatory process, endotheliopathy, hyperactivity of the coagulation cascade, which can lead to the development of micro-macrothrombosis and hypoxia. Clinically, it proceeds from asymptomatic to manifest forms with intoxication, fever, predominant lung damage and extrapulmonary lesions of various organs and systems (vascular endothelium, heart, kidneys, liver, pancreas, intestines, prostate, central and peripheral nervous systems) with a high risk of complications (ARDS, ODN, PE, sepsis, shock, SPON, OSN). The symptoms may be persistent and in some patients persist for more than 4 weeks (ongoing symptomatic (subacute) coronavirus infection COVID-19) and 12 weeks (the condition after COVID-19 is postcovid syndrome). The article describes in detail and illustrates the features of upper respiratory tract lesions in COVID-19 patients identified during autopsies.