Effect of undifferentiated connective tissue dysplasia on clinical course of varicose disease and thrombophlebitis of varicose veins after crossectomy
Автор: Oleg A. Tsarev, Nikolay N. Zakharov, Andrey A. Senin, Nikita V. Korchakov
Журнал: Saratov Medical Journal @sarmj
Статья в выпуске: 2 Vol.3, 2022 года.
Бесплатный доступ
Objective: to analyze the features of clinical course of lower limb varicose vein disease and acute thrombophlebitis of varicose veins for the patients with undifferentiated connective tissue dysplasia (UCTD) after crossectomy. Materials and Methods. The prospective clinical cohort study involved 132 female patients with varicose disease who underwent crossectomy, of which 67 patients with dysplasia were included into the main group, whereas patients without dysplasia were included into the control group. Examination of patients and ultrasound scanning of leg veins were conducted in 3, 6, 12, and 36 months. The Cox regression analysis was used to assess the effect of dysplasia on the risk of developing thrombophlebitis of varicose veins. Results. The progress of varicose disease clinical manifestations of after crossectomy was detected in 57 (85.1%) female patients with dysplasia and in 14 (21.5%) without it (р=0.002), which resulted in phlebectomy. The recurrent thrombophlebitis of varicose veins was found in 22 (32.8%) female patients with dysplasia vs. 5 (7.7%) without it (р=0.002). Cox regression model Exp (B), which characterizes the predicted change of risks for dysplasia, was 4.216 (95% CI 1.595-11.147). Conclusion. The clinical course of varicose disease in patients with UCTD is characterized by the progression of clinical manifestations of chronic venous insufficiency of a lower limb. UCTD results in over 4.2-fold risk of developing the recurrent thrombophlebitis of varicose veins after crossectomy.
Undifferentiated connective tissue dysplasia, varicose disease, recurrence of acute thrombophlebitis of varicose veins
Короткий адрес: https://sciup.org/149146152
IDR: 149146152 | DOI: 10.15275/sarmj.2022.0205
Список литературы Effect of undifferentiated connective tissue dysplasia on clinical course of varicose disease and thrombophlebitis of varicose veins after crossectomy
- Pokrovskiy AV, Gradus AV, Bredikhin RA. Diagnosis and Treatment of Varicose Disease. Moscow: RMAPO 2013; 125 р. [In Russ.]
- Stoyko YuM, Kirienko AI, Ilyukhin EA, et al. Diagnosis and treatment of superficial thrombophlebitis. Guidelines of the Russian Association of Phlebologists. Phlebology 2019; 13 (2): 78-97. [In Russ.] https://doi.org/10.17116/flebo20191302178
- Kirienko AI, Matyushenko AA, Andriyashkin VV. Acute Thrombophlebitis. 2nd ed. Moscow: Medical News Agency LLC 2019; 108 р. [In Russ.]
- Jeanneret C, Brunner S. Superficial venous thrombosis. A review. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und Verwandte Gebiete 2012; 63 (8): 609-15. https://doi.org/10.1007/s00105-012-2367-2
- Shevchenko YuL, Stoyko YuM. Clinical Phlebology. Moscow: DPK Press, 2016; 256 р. [In Russ.]
- Goldhaber S. Venous thromboembolism: Epidemiology and magnitude of the problem. Best Pract Res Clin Haematol 2012; 25 (3): 235-42. https://doi.org/10.1016/j.beha.2012.06.007
- Kudlaty E, Oriowo B, Yang M, еt al. Isolated great saphenous vein thrombus is associated with high rates of complications regardless of management. Ann Vasc Surg 2017; 45 (4): 154-9. https://doi.org/10.1016/j.avsg.2017.05.028
- Bachmeyer C. Risk for venous thromboembolism in patients with superficial venous thrombosis. Ann Intern Med 2010; 153 (1): 62-3. https://doi.org/10.7326/0003-4819-153-1-201007060-00023
- Heit JA, Spencer FA, White RH. The epidemiology of venous thromboembolism. J Thromb Thrombolysis 2016; 41 (1): 3-14. https://doi.org/10.1007/s11239-015-1311-6
- Milio G, Siragusa S, Minà C, et al. Superficial venous thrombosis: Prevalence of common genetic risk factors and their role on spreading to deep veins. Thromb Res 2008; 123(2): 194-9. https://doi.org/10.1016/j.thromres.2008.01.013
- Cosmi B. Management of superficial vein thrombosis. J Thromb Haemost 2015; 13 (7): 1175-83. https://doi.org/10.1111/jth.12986
- Frappé P, Buchmuller-Cordier A, Bertoletti L, et al. STEPH Study Group. Annual diagnosis rate of superficial vein thrombosis of the lower limbs: The STEPH community-based study. J Thromb Haemost 2014; 12 (6): 831-8. https://doi.org/10.1111/jth.12575
- Kalnу J, Tomaskova L, Pazin J. Superficial thrombophlebitis of the lower limbs from the surgeons point of view. Rozhl Chir 2014; 93 (5): 260-2, 264-70. http://www.ncbi.nlm.nih.gov/pubmed/24891243
- Karathanos C, Spanos K, Saleptsis V, et al. Recurrence of superficial vein thrombosis in patients with varicose veins. Phlebology 2016; 31 (7): 489-95. https://doi.org/10.1177/0268355515596475
- Studennikova VV, Severgina LO, Dzyundzia AN, Korovin IA. Varicose veins of lower limbs in childhood and adolescence: Mechanisms of development and specific features. Pathology Archive 2017; 79 (4): 56-60. [In Russ.]
- Zakharian ЕА. Morphological and phenotypic markers of connective tissue dysplasia in patients with varicose disease of the lower limbs. Zaporozhye Medical Journal 2013; (1): 12-6. [In Russ.]
- Tsarev OA, Anisimov AYu, Prokin FG, et al. The role of connective tissue dysplasia in etiopathogenesis of varicose disease and acute thrombophlebitis of varicose veins. Saratov Journal of Medical Scientific Research 2019; 15 (2): 302-7. [In Russ.]
- Clinical recommendations of the Russian Scientific Medical Society of Internists on the diagnosis, treatment and rehabilitation of patients with connective tissue dysplasia (first revision). Medical Bulletin of the North Caucasus 2018; 13(1, 2): 137-209. [In Russ.]
- Sushkov SA, Kukhenkov PA, Nebylitsyn YS, Sushkovа OS. Phenotypic symptom complex of connective tissue dysplasia under deep venous insufficiency in patients with varicose disease. News of Surgery 2006; (2): 32-7. [In Russ.]
- Klemenov AV. Hereditary connective tissue disorders: Nomenclature and diagnostic algorithm. The Clinician 2015; 9 (1): 42-9. [In Russ.] https://doi.org/10.17650/1818-8338-2015-1-42-49
