Эволюция спасительной терапии при биохимическом рецидиве рака предстательной железы после радикальной простатэктомии

Эволюция спасительной терапии при биохимическом рецидиве рака предстательной железы после радикальной простатэктомии

Автор: Павлов А.Ю., Дзидзария А.Г., Цыбульский А.Д., Мирзаханов Р.И., Халиль И.И.

Журнал: Вестник Российского научного центра рентгенорадиологии Минздрава России @vestnik-rncrr

Рубрика: Обзоры

Статья в выпуске: 2 т.23, 2023 года.

Бесплатный доступ

Биохимический рецидив (БХР) возникает в 30% случаев после радикальной простатэктомии (РПЭ) за 10-летний период наблюдения, однако, до сих пор эффективные варианты лечения таких пациентов остаются спорными. Несмотря на то, что простатический специфический антиген (ПСА) широко используется в качестве маркера прогрессирования заболевания после радикальной терапии, единый взгляд на его роль в качестве предиктора на общую и опухоль-специфичную выживаемость отсутствует. Учитывая тот факт, что БХР не всегда перетекает в клинический рецедив, клиницистам сложно определить необходимые сроки лечения, чтобы остановить или замедлить прогрессирование.Существуют несколько вариантов лечения БХР после РПЭ: адъювантная дистанционная лучевая терапия (АДЛТ), спасительная дистанционная лучевая терапия (СДЛТ) ложа удалённой предстательной железы и/или зоны регионарного лимфооттока, непрерывная или интермиттирующая спасительная андроген-депривационная терапия (АДТ), экспериментальные методики лечения, а также динамическое наблюдение. АДЛТ после РПЭ имеет свои преимущества с точки зрения выживаемости, однако, она не рекомендуется из-за значительных ранних и поздних лучевых осложнений. СДЛТ рекомендуется пациентам с БХР после РПЭ. При выборе наилучшей стратегии лечения необходимо учитывать сопутствующие заболевания, предпочтения пациентов, а также клинические и патоморфологические характеристики опухоли.

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Рецидив, спасительная лучевая терапия, спасительная брахитерапия, биохимический рецидив, рак предстательной железы, простатэктомия

Короткий адрес: https://sciup.org/149143494

IDR: 149143494

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