Choosing the optimal composition of the spray with the oil extract of Chelidonium majus l

According to the healthcare development concept of Kazakhstan until 2026, the share of domestic medicinal products is planned to increase to 30%. In this regard, the production of preparations from the plant Chelidonium majus L. (greater celandine) is of great importance. This plant has long been used for the treatment of skin diseases, particularly viral herpes, eczema, and warts. The biologically active compounds it contains exhibit anti-inflammatory and antibacterial properties, as well as the ability to inhibit the growth of malignant tumors. Developing a spray-based medicinal form from greater celandine represents one of the promising directions for ensuring effective treatment of skin diseases. The study was conducted at the Scientific Research Institute of Fundamental and Applied Medicine named after B. Atchabarov at the S.D. Asfendiyarov Kazakh National Medical University. The selection of the appropriate emulsifier was based on the merging of solution components when the emulsifier was added to the oil extract, as well as the amount of sediment formed within 24 hours and its ease of reconstitution after shaking. Seven different emulsifiers were tested during the study. Using the optimally selected emulsifier, several sample spray formulations based on the oil extract were developed. The selection of the optimal spray formulation was carried out using methods approved by the State Pharmacopoeia of the Republic of Kazakhstan. Various emulsifier options compatible with the oil extract were tested for spray production. The best result was demonstrated by the composition based on Tween-80. This emulsifier quickly emulsified the components, forming a transparent, homogeneous system and providing easy restoration of sediment structure after shaking during storage. Other emulsifiers either failed to create a homogeneous system or demonstrated low stability; thus, the composition based on Tween-80 was chosen for further research. Various excipients were tested for the development of a spray based on the oil extract of greater celandine. Composition No. 8, developed on the basis of polyethylene oxide (PEO), was recognized as optimal. It successfully passed tests for resistance to cold and thermal exposure, maintained its organoleptic properties, and prevented sediment formation. The remaining compositions did not meet the requirements for stability, pH, or consistency, so further research was continued with Composition No. 8.