Повышенный уровень сыворотки гомоцистеина и действия глутатиона-С-трансферазы у пациентов с алкогольной зависимостью, посещающих наркологический центр

Повышенный уровень сыворотки гомоцистеина и действия глутатиона-С-трансферазы у пациентов с алкогольной зависимостью, посещающих наркологический центр

Автор: Кулкарни С.Р., Равиндра К.П., Дъюме С., Ратаболи П.В., Родригез Э., Родригез Э.Е.

Журнал: Саратовский научно-медицинский журнал @ssmj

Рубрика: Клиническая лабораторная диагностика

Статья в выпуске: 3 т.6, 2010 года.

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Изучался эффект от интенсивного употребления алкоголя на сыворотку малондиалдегида, состояние гомоцистеина и активность глутатиона-с-трансферазы у алкоголиков из низкого социально-экономического слоя населения, употреблявших запрещенные (несертифицированные) спиртные напитки и посещавших наркологический центр. В исследовании участвовали 90 пациентов с алкогольной зависимостью, употреблявших запрещенные спиртные напитки и посещавших наркологический центр, и контрольная группа - 90 лиц без алкогольной зависимости. Были оценены сыворотка малондиалдегида, сыворотка гомоцистеина и активность антиоксидант-фермента глутатиона-с-трансферазы. У алкоголиков, употреблявших запрещенные спиртные напитки и посещавших наркологический центр, выявлен значительно более высокий показатель концентрации сыворотки малондиалдегида, уровня сыворотки гомоцистеина и глутатиона-с-трансферазы в сравнении с контрольной группой, принадлежащей к такому же социально-экономическому слою населения. Результаты исследования показали, что с увеличением концентрации сыворотки малондиалдегида, сыворотки гомоцистеина и активности антиоксидант-фермента глутатиона-с-трансферазы может усиливаться восприимчивость к сосудистым заболеваниям при интенсивном употреблении запрещенных спиртных напитков и при недостаточном, неполноценном питании

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Алкоголь, глутатион-с-трансфераза, гомоцистеин

Короткий адрес: https://sciup.org/14917141

IDR: 14917141

Список литературы Повышенный уровень сыворотки гомоцистеина и действия глутатиона-С-трансферазы у пациентов с алкогольной зависимостью, посещающих наркологический центр

  • Sam Zakhari. Alcohol and the Cardiovascular System, Molecular Mechanisms for Beneficial and Harmful Action//Alcohol and the Cardiovascular System. 1997. Vol. 21, №. 1. P. 21-29
  • Marmot M, Brunner E. Alcohol and cardiovascular disease: the status of the U shaped curve//British Medical Journal. 1991. Vol. 303. P. 565-568.
  • Jackson R, Schragg R, Beaglehole R. Alcohol consumption and risk of coronary heart disease//British Medical Journal. 1991. Vol.303. P. 211-216.
  • Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors/R. Doll, R. Peto, E. Hall [et al.]//British Medical Journal. 1994. Vol. 309. P. 911-918.
  • Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use/K.M. Koehler, R.N. Baumgartner, PJ. Garry [et al.]//American Journal of Clinical Nutrition. 2001. Vol. 73. P. 628-637.
  • Halsted C.H. Lifestyle effects on homocysteine and an alcohol paradox//American Journal of Clinical Nutrition. 2001. Vol. 73. P. 501-502.
  • A prospective study of Plasma homocyst(e)ine and risk of myocardial infarction in US physicians/M.J. Stampfer, M.R. Ma-linow, W. Willett [et al.]//The Journal of the American Medical Association. 1992. Vol. 268. P. 877-881.
  • Hyperhomocysteinemia: an independent risk factor for vascular disease/R. Clarke, L. Daly, K. Robinson [et al.]//The New England Journal of Medicine. 1991. Vol. 324. P. 1149-1155.
  • Jacques P.F., Bostom A.G.,Wilson P.W.F. [et al.] Determinants of plasma total homocysteine concentration in the Fram-ingham Offspring cohort//American Journal of Clinical Nutrition. 2001. Vol.73. P. 613-621.
  • Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status/M.L. Cravo, L.M. Gloria, J. Selhub [et al.]//American Journal of Clinical Nutrition. 1996. Vol. 63. P. 2202-2224.
  • Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial/J. Woodside, J.W.G. Yarnell, D. McMas-ter [et al.]//American Journal of Clinical Nutrition. 1998. Vol. 67. P. 85-166.
  • Klee G.G. Cobalamin and Folate Evaluation: Measurement of Methylmalonic Acid and Homocysteine vis Vitamin B12//American Journal of Clinical Chemistry. 2000. Vol. 46. P. 1277-1283.
  • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population/J. Sesylhub, PF. Jacques, P.W.F. Wilson [et al.]//The Journal of the American Medical Association. 1993. Vol. 270. P. 2693-2698.
  • Reduction of plasma homocysteine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease/M.R. Malinow, PB. Duell, D.L. Hess [et al.]//The New England Journal of Medicine. 1998. Vol. 338. P. 1009-1015.
  • Hyperhomocysteinemia in Japanese patients with convalescent stage ischemic stroke: Effect of combined therapy with folic acid and mecobalamine/Y. Sato, M. Kaji, M. Kondo [et al.]//The Journal of Neuroscience. 2002. Vol. 202. P. 65-68.
  • Evaluation of serum homocysteine in patients with unstable angina, a new potential risk factor/Salahuddin, M.A. Sid-diqui, S. [et al.]//Pakistan Journal of Pharmaceutical Sciences. 2001. Vol. 18. P. 17-22.
  • Cederbaum A.I. Role of lipid peroxidation and oxidative stress in alcohol toxicity//Free Radical Biology and Medicine. 1989. Vol.7. P. 537-539.
  • Baraona E., Lieber C.S. Effects of ethanol on lipid metabolism//Journal of Lipid Research. 1979. Vol. 20. P. 289-315.
  • Oxidative stress in ovarian cancer/F. Tas, H. Hansel, A. Belce [et al.]//Medical Oncology. 2005. Vol. 22(1). P. 11-15.
  • Superoxide anion radical, lipid peroxides and antioxidant status in the blood of patients with ovarian cancer/C.C.Yeh, M.F. Hou, S.M. Tsai [et al.]//Clinica Chimica Acta, Nov. 2005. Vol. 381 (1-2). P. 104-111.
  • Sie H. Oxidative stress: from basic research to clinical application//American Journal of Medicine. 1988. № 9. P. 31-38.
  • Cotgreave I., Moldeus P., Orrenius S. Host biochemical defense mechanisms against prooxidants//Annual Review of Pharmacology and Toxicology. 1988. Vol. 28. P. 189-212.
  • Del vecchio bianco. Determination of Plasma a-Glutathione-STransferase in Chronic Alcohol abusers: Relationship with alcohol intake an Liver involvement/V Loguercio, A. Degirolamo, F. Cuomo [et al.]//Alcohol & Alcoholism. 1998. Vol. 33. P. 366-372.
  • Ewing J. A. Detecting Alcoholism: The CAGE Questionnaire//The Journal of the American Medical Association. 1984. Vol. 252(1+). P. 190-197.
  • Selzer M.L. The Michigan Alcoholism Screening Test: The quest for a new diagnostic instrument//The American Journal of Psychiatry. 1971. Vol. 127. P. 1653-165.
  • AUDIT: The Alcohol Use Disorders Identification Test Guidelines for Use in Primary Health Care/T.F. Babor, J.R. De la Fuente, J. Saunders [et al.]. Geneva: World Health Organization, 1992.
  • Stockwell T, Sitharathan T, McGrath & Lang E. The measurement of alcohol dependence and impaired control in community sample//Addiction. 1994. Vol.69. P. 167-174.
  • Ghai and Gupta, Essential Preventive Medicine. Chapter 4. P. 105-175.
  • Fagerstrom, K.O. Measuring Degree of Physical Dependence to Tobacco Smoking With Reference to Individualization of Treatment//The Behaviors of Addiction. 1978. Vol. 3. P. 235-241.
  • Mahajan B.K., Gupta M.C. Chapter 11: Social Environment//Textbook of Preventive and Social Medicine. Second edition, 1991. P. 134-135.
  • Kuppuswamy B. Revised.Manual of socioeconomic status scale (Urban). Delhi: Manasayan, 32 Netaji Subhash Marg., 1981.
  • Zoecklien Bruce W. Determination of Alcohol Content Chapter №.20 Wine Analysis & Production//Laboratory Procedures. 1995. P. 407-408.
  • Habig Wlliam H., Michael J. Pabst, William B. Jakoby. Glutathione S-Transferases: The First Enzymatic Step In Mer-capturic Acid Formation//The Journal of Biological Chemistry. 1974. Vol. 249. P. 7130-7139.
  • Wlbur K.M., Frederick В., Shapiro O.W. The thiobarbitu-ricacid reagent as a test for the oxidation products of unsaturated fatty acids by various agents//Archives of Biochemistry and Biophysics. 1949. P. 305-313.
  • Buege and Aust. Microsomal lipid peroxidation//Methods in enzymology. 1978. Vol. 105. P. 302-310.
  • Stell R.G.U., Torrie J.H. Principles and procedures of statistics. N. Y: Mc Graw Hill, 1960. P. 78.
  • Lipid peroxidation in alcoholic liver disease in man/T. Matsumura, T. Suetmatsu, N. Sato//Advances in Experimental Medicine and Biology. 1980. Vol. 132. P. 287-293.
  • Lipid peroxidation in Alcoholic liver disease in humans.//M.D. Suematsu Toshihiko, M.D. Matsumura Takakatsu, M.D. Sato Nobuhiro/Alcohol Clinical and Experimental Research. 1981. Vol. 5(3). P. 427-430.
  • Tumor Necrosis Factor Soluble Receptor p55 and Lipid Peroxidation in Patients With Acute Alcoholic Hepatitis/M.D. Naveau Sylvie, M.D. Abella Annie, M.D. Raynard Bruno//The American Journal of Gastroenterology. 2001. Vol. 96. P. 3362-3367.
  • Cytochrome P4502E1 inducibility and hydroxythyl radical formation among alcoholics/Dupont Isabelle, Lucas Daniele, Clot Paolo [et. al.]//Journal of Hepatology. 1998. Vol. 28. P. 564-571.
  • Paramahemsa M., Aparna S., Varadacharyulu N. Alcohol-Induced Alterations in blood and erythrocyte membrane in diabetics//Alcohol & Alcoholism. 2002. Vol. 37 (1). P. 49-51.
  • Das Subir K., Vasudeven D.M., Ucar Gulberk, Demir Ba-saran. Plasma Semicarbazide-Sensitive Amine Oxidase Activity in type I and II Alcoholics//Turkish Journal of Biochemistry. 2003. Vol. 28 (4). P. 257-263.
  • Biochemical Diagnosis of alcoholism//Indian journal of clinical biochemistry. 2005. Vol. 20 (1). P. 35-42.
  • Paramahemsa M., Aparna S., Varadacharyulu N. Alcohol-Induced Alterations in blood and erythrocyte membrane in diabetics//Alcohol & Alcoholism. 2002. Vol. 37 (1). P. 49-51.
  • Lipid Peroxidation contributes to immune reactions Associated with alcoholic liver disease/Elisa Mottaran, Stephen F. Stewart, Roberta Rolla [et al.]//Free Radical Biology & Medicine. 2001. Vol. 332(1). P. 38-45.
  • Smith G.J., Ohl VS., Litwack G. The Glutathione-S-Transferases, and chemically induced hepato carcinogenesis//A review Cancer Research. 1977. Vol. 37. P. 8-14.
  • The effect of betaine treatment on triglyceride levels and oxidative stress in the liver of ethanol-treated guinea pigs/Balkan Jale, Serdar Oztezcan, Mutlu Kucuk//Experimental and Toxicologic Pathology. 2004. Vol. 55. P. 505-509.
  • Chen L.H., Xi S., Cohen D.A. Liver Antioxidant defenses in mice fed ethanol and the AIN-76A Diet//Alcohol. 1995. Vol. 12 (5). P. 453-457.
  • Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status/M.L. Cravo, L.M. Gloria, J. Selhub [et al.]//American Journal of Clinical Nutrition. 1996. Vol. 63. P. 220-224.
  • Elevated plasma homocysteine in alcoholics/B. Hult-berg, M. Berglund, A. Andersson, [et al.]//Alcohol Clinical Experimental Research. 1993. Vol. 17. P. 687-689.
  • Barak A. J., Beckenhauer H.C., Tuma D.J. Effects of prolonged ethanol feeding on methionine metabolism in rat liver//Biochemistry and Cell Biology. 1987. Vol. 65. P. 230-233.
  • Sullivan L.W., Herbert V Suppression of hematopoei-sis by ethanol//Journal of Clinical Investigation. 1964. Vol. 43. P. 2048-2061.
  • Halsted C.H., Robles E.A., Mezey E. Decreased Jejunal uptake of labeled folic acid (3H-PGA) in alcoholic patients: role of alcohol and nutrition//New England Journal of Medicine. 1971. Vol.285. P. 701-706.
  • Halsted C.H., Keen C.L. Alcoholism and micronutrient metabolism and deficiencies//European Journal of Gastroenterology and Hepatology. 1990. Vol. 2. P. 399-405.
  • Kang S.S., Wong P.W.K., Norusis M. Homocysteinemia due to folate deficiency//Metabolism. 1987. Vol. 36. P. 458-462.
  • Kang S.S. Critical points for determining moderate hyper Homocysteinemia//European Journal of Clinical Investigation. 1995. Vol. 25. P. 806-808.
  • Genetic and neurobiological basis of alcohol -seeking behavior/T.-K. Li, L. Lumeng, W.J. Mc Bridge, J.M. Murthy//Alcohol and Alcoholism. 1994. Vol. 29. P. 697-700.
  • Fluprtine shows functional NMDA receptor antagonism by enhancing Mg 2+ block via activation of voltage independent potassium channels/J. Konhubar, S. Bleich, J. Willfang [et al.]//Journal of Neural Transmission. 1999. Vol. 106. P. 857-867.
  • Bleich S., Degner D., Kornhuber J. Repeated ethanol withdrawal delays development of focal seizures in hippocam-pal kindling//Alcohol Clinical and Experimental Research. 2000. Vol. 24. P. 244-245.
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