Спорные вопросы адъювантной химиотерапии рака прямой кишки второй стадии

Автор: Федянин М.Ю.

Журнал: Злокачественные опухоли @malignanttumors

Рубрика: Медицинские науки

Статья в выпуске: 3 (10), 2014 года.

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Тезисы статьи: При II и III стадии рака прямой кишки (cT3/сТ 4 или cN+) в большинстве случаях стандартным подходом в лечебной тактике является сочетание хирургического и предоперационного химиолучевого лечения. Такой подход позволяет значимо снизить частоту рецидивов болезни, а в некоторых исследованиях приводит к улучшению общей выживаемости. Однако в течение последующих 10 лет от 30% при IIa до 70% больных при IIIc стадии погибают от прогрессирования болезни. При этом прогрессирование заболевания у большинства реализуется через отдаленное метастазирование, что диктует необходимость совершенствования системной терапии. Основным методом профилактики отдаленного метастазирования при ранних стадиях болезни является адъювантная химиотерапия. Однако к настоящему времени данные об эффективности послеоперационного лечения при раке прямой кишки после предоперационной химиолучевой терапии остаются противоречивыми. Настоящий обзор литературы посвящен анализу результатов исследований, посвященных оценке эффективности адъювантной химиотерапии у больных раком прямой кишки после проведенного предоперационного лечения при II стадии болезни.

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Рак прямой кишки, адъювантная химиотерапия

Короткий адрес: https://sciup.org/14045484

IDR: 14045484

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