The state of free-radicals processes in cardiomyocytes in rats under the action of doxorubicin and protection by preductal

The state of free-radicals processes in cardiomyocytes in rats under the action of doxorubicin and protection by preductal

Автор: Kit Oleg I., Frantsiyants Elena M., Neskubina Irina V., Surikova Ekaterina I., Shalashnaya Elena V., Nemashkalova Lyudmila A., Cheryarina Natalia D., Kozyuk Olga V., Pogorelova Yulia A., Kozlova Larisa S., Bandovkina Valeria A., Kaplieva Irina V., Trepitaki Lidia K., Myagkov Roman E., Kozhushko Mikhail А., Sanamyants Sergey V., Averkin Mikhail А., Tolmakh Roman Е.

Журнал: Cardiometry @cardiometry

Рубрика: Original research

Статья в выпуске: 13, 2018 года.

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Aims The aim of our research work was to investigate the state of the lipid peroxidation system - the antioxidant protection system (LPO-AOS) in heart tissue in rats received either Doxorubicin alone or in combination with Preductal premedication. Materials and methods Our experimental studies were carried out in mature male albino rats from outbread stocks (the cohort covered 50 animals) with an individual body mass from 150 to 160 g. The cohort included the following groups of the rats: the reference group covered 10 intact animals; group 1 (20 rats) received dosage of Doxorubicin of 2mg/kg, five times, up to a cumulative dose of 10 mg/kg; group 2 (20 animals) medicated as follows: the 5-day introduction of Preductal with dosage of 35 mg/kg followed by Doxorubicin medication according to the same schedule used in group 1. MDA, levels of the A & E vitamins, SOD and catalase activity, Total Peroxidase Activity (TPA), the ratios E/A, SOD/TPA and SOD/catalase were assessed in heart tissue...

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Сardiomyocyte, doxorubicin, preductal, lipid peroxidation, antioxidant protection

Короткий адрес: https://sciup.org/148308852

IDR: 148308852   |   DOI: 10.12710/cardiometry.2018.13.4853

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