Фармакометрика как инструмент клинической фармакологии для оптимизации режима дозирования лекарственных средств во время беременности

Автор: Решетько О.В., Луцевич К.А.

Журнал: Саратовский научно-медицинский журнал @ssmj

Статья в выпуске: 1 т.10, 2014 года.

Бесплатный доступ

Изменения физиологических и метаболических процессов во время беременности оказывает влияние на фармакокинетику лекарственных средств, иллюстрируя возможность некорректности стандартного режима до- зирования во время беременности. Различные фармакометрические подходы доступны для дизайна и анализа клинических исследований во время беременности. Физиологически обоснованная фармакокинетическая (physiology-based pharmacokinetic, РВРК) модель может быть использована для оценки различных режимов дозирования ЛС у беременных женщин и полезна в предсказании лекарственного воздействия и ответа на него на индивидуальном уровне.

Беременность, фармакокинетика, фармакометрика

Короткий адрес: https://sciup.org/14917916

IDR: 14917916

Список литературы Фармакометрика как инструмент клинической фармакологии для оптимизации режима дозирования лекарственных средств во время беременности

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