Фотодинамическая терапия при раке легкого: основные показания к применению

Автор: Рагулин Юрий Александрович, Галкин Всеволод Николаевич

Журнал: Сибирский онкологический журнал @siboncoj

Статья в выпуске: 4 (76), 2016 года.

Бесплатный доступ

Лечение рака легкого продолжает оставаться одной из наиболее актуальных проблем современной онкологии. Фотодинамическая терапия (ФДТ) зарекомендовала себя эффективным методом лечения злокачественных опухолей, в том числе внутригрудной локализации. В данной статье оценены результаты применения ФДТ по основным показаниям при раке легкого. Дан анализ эффективности в различных клинических ситуациях, представлены перспективы развития метода.

Рак легкого, фотодинамическая терапия, комбинированное лечение

Короткий адрес: https://sciup.org/140253952

IDR: 140253952 | DOI: 10.21294/1814-4861-2016-15-4-79-87

Список литературы Фотодинамическая терапия при раке легкого: основные показания к применению

Состояние онкологической помощи населению России в 2014 году/Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. Москва: МНИОИ им. П.А. Герцена -филиал ФГБУ «НМИРЦ» Минздрава России; 2015, 236 с.
Siegel R., Ma J., Zou Z., Jemal A. Cancer statistics, 2014 CACancer. J Clin. 2014 Jan-Feb; 64 (1): 9-29 DOI: 10.3322/caac.21208
Ono R., Ikeda S., Suemasu K. Hematoporphyrin derivative photodynamic therapy in roentgenographically occult carcinoma of the tracheobronchial tree. Cancer. 1992 Apr 1; 69 (7): 1696-701.
Furuse K., Fukuoka M., Kato H., Horai T., Kubota K., Kodama N., Kusunoki Y., Takifuji N., Okunaka T., Konaka C. A prospective phase II study on photodynamic therapy with photofrin II for centrally located early-stage lung cancer. The Japan Lung Cancer Photodynamic Therapy Study Group. J Clin Oncol. 1993 Oct; 11 (10): 1852-7.
Imamura S., Kusunoki Y., Takifuji N., Kudo S., Matsui K., Masuda N., Takada M., Negoro S., Ryu S., Fukuoka M. Photodynamic therapy and/or external beam radiation therapy for roentgenologically occult lung cancer. Cancer. 1994 Mar 15; 73 (6): 1608-14.
Cortese D.A., Edell E.S., Kinsey J.H. Photodynamic therapy for early stage squamous cell carcinoma of the lung. Mayo Clin Proc. 1997 Jul; 72 (7): 595-602.
Kato H. Photodynamic Therapy for Lung Cancer: A Review of 19 Years Experience. J Photochem Photobiol B. 1998 Feb; 42 (2): 96-9.
Lam S., Haussinger K., Leroy M., Sutedja Т., Huber R.M. Photodynamic therapy (PDT) with Рhotofrin®, a treatment with curative potential for early-stage superficial lung cancer . Proc. Am. Soc. Clin. Oncol. 1998. 17. Abstract 1781.
Patelli M., Lazzari Agli L., Poletti V., Falcone F. Photodynamic laser therapy for the treatment of early-stage bronchogenic carcinoma. Monaldi Arch Chest Dis. 1999 Aug; 54 (4): 315-8.
Соколов В.В., Телегина Л.В., Трахтенберг А.Х., Пикин О.В., Осипова Н.А., Бойко А.В., Франк Г.А., Белоус Т.А. Эндобронхиальная хирургия и фотодинамическая терапия при злокачественных опухолях трахеи и бронхов. Российский онкологический журнал. 2010; 3: 4-9.
Ali A.H., Takizawa H., Kondo K., Nakagawa Y., Toba H., Khasag N., Kenzaki K., Sakiyama S., Mohammadien H.A., Mokhtar E.A., Tangoku A. Follow-up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer. J Med Invest. 2011 Feb; 58 (1-2): 46-55.
Endo C., Miyamoto A., Sakurada A.,Aikawa H., Sagawa M., Sato M., Saito Y., Kondo T. Results of long-term follow-up of photodynamic therapy for roentgenographically occult bronchogenic squamous cell carcinoma. Chest. 2009 Aug; 136 (2): 369-75 DOI: 10.1378/chest.08-2237
Hopwood P., Stephens R.J. Symptoms at presentation for treatment in patients with lung cancer: implications for the evaluation of palliative treatment. The Medical Research Council (MRC) Lung Cancer Working Party. Br J Cancer. 1995 Mar; 71 (3): 633-6.
Lutz S., Norrell R., Bertucio C., Kachnic L., Johnson C., Arthur D., Schwarz M., Palardy G. Symptom frequency and severity in patients with metastatic or locally recurrent lung cancer: a prospective study using the Lung Cancer Symptom Scale in a community hospital. J Palliat Med. 2001 Summer; 4 (2): 157-65.
Maione P., Perrone F., Gallo C., Manzione L., Piantedosi F., Barbera S., Cigolari S., Rosetti F., Piazza E., Robbiati SF., Bertetto O., Novello S., Migliorino M.R., Favaretto A., Spatafora M., Ferraù F., Frontini L., Bearz A., Repetto L., Gridelli C., Barletta E., Barzelloni M.L., Iaffaioli R.V., De Maio E., Di Maio M., De Feo G., Sigoriello G., Chiodini P., Cioffi A., Guardasole V., Angelini V., Rossi A., Bilancia D., Germano D., Lamberti A., Pontillo V., Brancaccio L., Renda F, Romano F, Esani G., Gambaro A., Vinante O, Azzarello G., Clerici M., Bollina R., Belloni P., Sannicolò M., Ciuffreda L., Parello G., Cabiddu M., Sacco C., Sibau A., Porcile G., Castiglione F., Ostellino O., Monfardini S., Stefani M., Scagliotti G., Selvaggi G.,DeMarinis F.,Martelli O.,Gasparini G.,Morabito A.,Gattuso D., Colucci G., Galetta D., Giotta F., Gebbia V., Borsellino N., Testa A., Malaponte E., Capuano M.A., Angiolillo M., Sollitto F., Tirelli U., Spazzapan S., Adamo V., Altavilla G., Scimone A., Hopps M.R., Tartamella F., Ian-niello G.P., Tinessa V., Failla G., Bordonaro R., Gebbia N., Valerio M.R., D’Aprile M.,Veltri E.,Tonato M.,Darwish S.,Romito S.,Carrozza F.,Barni S., Ardizzoia A.,Corradini G.M.,Pavia G.,Belli M.,Colantuoni G.,Galligioni E., Caffo O., Labianca R., Quadri A., Cortesi E., D’Auria G., Fava S., Calcagno A., Luporini G., Locatelli M.C., Di Costanzo F., Gasperoni S., Isa L., Candido P., Gaion F., Palazzolo G., Nettis G., Annamaria A., Rinaldi M., Lopez M., Felletti R., Di Negro G.B., Rossi N., Calandriello A., Maiorino L., Mattioli R., Celano A., Schiavon S., Illiano A., Raucci C.A., Caruso M., Foa P., Tonini G., Curcio C., Cazzaniga M. Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung cancer receiving chemotherapy: a prognostic analysis of the multicenter Italian lung cancer in the elderly study. J Clin Oncol. 2005 Oct 1; 23 (28): 6865-72.
Movsas B., Moughan J., Sarna L., Langer C., Werner-Wasik M., Nicolaou N., Komaki R., Machtay M., Wasserman T., Bruner D.W. Quality of life supersedes the classic prognosticators for long-term survival in locally advanced non-small-cell lung cancer: an analysis of RTOG 9801. J Clin Oncol. 2009 Dec 1; 27 (34): 5816-22 DOI: 10.1200/JCO.2009.23.7420
Ono R., Ikeda S., Suemasu K. Hematoporphyrin derivative photodynamic therapy in roentgenographically occult carcinoma of the tracheobronchial tree. Cancer. 1992 Apr 1; 69 (7): 1696-701.
Рагулин Ю.А. Фотодинамическая терапия с фотосенсибилизаторами хлоринового ряда в комбинированном лечении центрального рака легкого . , 2007. 18 с.
McCaughan J.S., Hawley P.C., LaRosa J.C., Thomas J.H., Hicks W.J. Photodynamic therapy to control life-threatening hemorrhage from hereditary hemorrhagic telangiectasia. Lasers Surg Med. 1996; 19 (4): 492-4.
Pass H.I., Delaney T., Smith P.D., Bonner R., Russo A. Bronchoscopic phototherapy at comparable dose rates: early results. Ann Thorac Surg. 1989 May; 47 (5): 693-9.
Li J.H., Guo Z.H., Jin M.L., Zhao F.Y., Cai W.M., Gao M.L., Shu M.Y., Zou J. Photodynamic therapy in the treatment of malignant tumours: an analysis of 540 cases. J Photochem Photobiol B. 1990 Jun; 6 (1-2): 149-55.
Sutedja T., Baas P., Stewart F., van Zandwijk N. A pilot study of photodynamic therapy in patients with inoperable non-small cell lung cancer. Eur J Cancer. 1992; 28A (8-9): 1370-3.
Ono R., Egawa S., Ikeda S. Combined treatment of endoscopic laser irradiation and radiotherapy in lung cancer. Gan To Kagaku Ryoho. 1989 Apr; 16 (4 Pt 2-2): 1418-24.
LoCicero J., Metzdorff M., Almgren C. Photodynamic therapy in the palliation of late stage obstructing non-small cell lung cancer. Chest. 1990 Jul; 98 (1): 97-100.
Moghissi K., Dixon K., Stringer M., Freeman T., Thorpe A., Brown S. The place of bronchoscopic photodynamic therapy in advanced unresectable lung cancer: experience of 100 cases. Eur J Cardiothorac Surg. 1999 Jan; 15 (1): 1-6.
Яицкий Н.А., Молодцова В.П., Орлов С.В., Стельмах Л.В., Герасин В.А., Деревянко А.В., Бутенко А.Б., Уртенова М.А., Герасин А.В. Фотодинамическая терапия в лечении рака легкого. Вестник хирургии им. И.И. Грекова. 2010; 169 (5): 31-34.
Jones B.U., Helmy M., Brenner M., Serna D.L., Williams J., Chen J.C., Milliken J.C. Photodynamic therapy for patients with advanced non-small-cell carcinoma of the lung. Clin Lung Cancer. 2001 Aug; 3 (1): 37-41.
Minnich D.J., Bryant A.S., Dooley A., Cerfolio R.J. Photodynamic laser therapy for lesions in the airway. Ann Thorac Surg. 2010 Jun; 89 (6): 1744-8; discussion 1748-9 DOI: 10.1016/j.athoracsur.2010.02.025
Cardona A.F., Reveiz L., Ospina E.G., Ospina V., Yepes A. Palliative endobronchial brachytherapy for non-small cell lung cancer. Cochrane Database Syst Rev. 2008 Apr 16; (2): CD004284. CD004284.pub2 DOI: 10.1002/14651858
Stephens K.E., Wood D.E. Bronchoscopic management of central airway obstruction. J Thorac Cardiovasc Surg. 2000 Feb; 119 (2): 289-96.
Taber S.W., Buschemeyer W.C., Fingar V.H., Wieman T.J. The treatment of malignant endobronchial obstruction with laser ablation Surgery. 1999 Oct; 126 (4): 730-3; discussion 733-5.
Karanov S., Kostadinov D., Shopova M., Kurtev P. Photodynamictherapy in lung and gastrointestinal cancers. J Photochem Photobiol B. 1990 Jun; 6 (1-2): 175-81.
Furukawa K., Okunaka T., Yamamoto H., Tsuchida T., Usuda J., Kumasaka H., Ishida J., Konaka C., Kato H. Effectiveness of photodynamic therapy and Nd-YAG laser treatment for obstructed tracheobronchial malignancies. Diagn Ther Endosc. 1999;5(3):161-6 DOI: 10.1155/DTE.5.161
Santos R.S., Raftopoulos Y., Keenan R.J., Halal A., Maley R.H., Landreneau R.J. Bronchoscopic palliation of primary lung cancer: single or multimodality therapy? Surg Endosc. 2004 Jun; 18 (6): 931-6.
Diaz-Jiménez J.P., Martínez-Ballarín J.E., Llunell A., Farrero E., Rodríguez A., Castro M.J. Efficacy and safety of photodynamic therapy versus Nd-YAG laser resection in NSCLC with airway obstruction. Eur Respir J. 1999; 14 (4): 800-5.
Konaka C., Usuda J., Kato H. Preoperative photodynamic therapy for lung cancer. Nihon Geka Gakkai Zasshi. 2000 Jul; 101 (7): 486-9.
Okunaka T., Hiyoshi T., Furukawa K., Yamamoto H., Tsuchida T., Usuda J., Kumasaka H., Ishida J., Konaka C., Kato H. Lung cancers treated with photodynamic therapy and surgery. Diagn Ther Endosc. 1999; 5 (3): 155-60 DOI: 10.1155/DTE.5.155
Akopov A., Rusanov A., Gerasin A., Kazakov N., Urtenova M., Chistyakov I. Preoperative endobronchial photodynamic therapy improves resectability in initially irresectable (inoperable) locally advanced non small cell lung cancer. Photodiagnosis Photodyn Ther. 2014 Sep; 11 (3): 259-64 DOI: 10.1016/j.pdpdt.2014.03.011
Ross P., Grecula J.,Bekaii-Saab T.,Villalona-Calero M., Otterson G., Magro C. Incorporation of photodynamic therapy as an induction modality in non-small cell lung cancer. Lasers Surg Med. 2006 Dec; 38 (10): 881-9.
Perez C.A., Brady L.W. Principles and Practice of Radiation Oncology. 2nd Edition. 50-63. Philadelphia: JB Lippincott Co.; 1992. Р. 114-123.
Lam S., Kostashuk E.C., Coy E.P., Laukkanen E., LeRiche J.C., Mueller H.A., Szasz I.J. A randomized comparative study of the safety and efficacy of photodynamic therapy using Photofrin II combined with palliative radiotherapy versus palliative radiotherapy alone in patients with inoperable obstructive non-small cell bronchogenic carcinoma. Photochem Photobiol. 1987; 46 (5): 893-7.
Freitag L., Ernst A., Thomas M., Prenzel R., Wahlers B., Macha H.N. Sequential photodynamic therapy (PDT) and high dose brachytherapy for endobronchial tumour control in patients with limited bronchogenic carcinoma. Thorax. 2004 Sep; 59 (9): 790-3.
Weinberg B.D., Allison R.R., Sibata C., Parent T., Downie G. Results of combined photodynamic therapy (PDT) and high dose rate brachytherapy (HDR) in treatment of obstructive endobronchial non-small cell lung cancer (NSCLC). Photodiagnosis Photodyn Ther. 2010 Mar; 7 (1): 50-8 DOI: 10.1016/j.pdpdt.2009.12.002
Арсеньев А.И., Гельфонд М.Л., Барчук А.С., Левченко Е.В., Канаев С.В., Барчук А.А., Шулепов А.В., Веденин Я.О., Нефедов А.О. Проведение эндотрахеобронхиальных операций в комбинации с сочетанной химиолучевой терапией и фотодинамической терапией в комплексном лечении злокачественных опухолей центральных бронхов и трахеи. Сибирский онкологический журнал. 2010; 2: 7-8.
Okunaka T., Kato H., Tsutsui H., Ishizumi T., Ichinose S., Kuroiwa Y. Photodynamic therapy for peripheral lung cancer. Lung Cancer. 2004 Jan; 43 (1): 77-82.
Tomaselli F., Maier A., Sankin O., Anegg U., Stranzl U., Pinter H., Kapp K., Smolle-Juttner F.M. Acute effects of combined photodynamic therapy and hyperbaric oxygenation in lung cancer-a clinical pilot study. Lasers Surg Med. 2001; 28 (5): 399-403.
Соколов В.В., Телегина Л.В., Гладышев А.А., Соколов С.А. Клинический опыт МНИОИ им. П.А. Герцена по диагностике и эндобронхиальному лечению больных ранним центральным раком легкого. Онкология. Журнал им. П.А. Герцена. 2014; 2 (4): 4-10.
Ali A.H., Takizawa H., Kondo K., Nakagawa Y., Toba H., Khasag N., Kenzaki K., Sakiyama S., Mohammadien H.A., Mokhtar E.A., Tangoku A. Follow-up using fluorescence bronchoscopy for the patients with photodynamic therapy treated early lung cancer. J Med Invest. 2011 Feb; 58 (1-2): 46-55.
Endo C., Miyamoto A., Sakurada A.,Aikawa H., Sagawa M., Sato M., Saito Y., Kondo T. Results of long-term follow-up of photodynamic therapy for roentgenographically occult bronchogenic squamous cell carcinoma. Chest. 2009 Aug; 136 (2): 369-75 DOI: 10.1378/chest.08-2237
Hopwood P., Stephens R.J. Symptoms at presentation for treatment in patients with lung cancer: implications for the evaluation of palliative treatment. The Medical Research Council (MRC) Lung Cancer Working Party. Br J Cancer. 1995 Mar; 71 (3): 633-6.
Lutz S., Norrell R., Bertucio C., Kachnic L., Johnson C., Arthur D., Schwarz M., Palardy G. Symptom frequency and severity in patients with metastatic or locally recurrent lung cancer: a prospective study using the Lung Cancer Symptom Scale in a community hospital. J Palliat Med. 2001 Summer; 4 (2): 157-65.
Maione P., Perrone F., Gallo C., Manzione L., Piantedosi F., Barbera S., Cigolari S., Rosetti F., Piazza E., Robbiati SF., Bertetto O., Novello S., Migliorino M.R., Favaretto A., Spatafora M., Ferraù F., Frontini L., Bearz A., Repetto L., Gridelli C., Barletta E., Barzelloni M.L., Iaffaioli R.V., De Maio E., Di Maio M., De Feo G., Sigoriello G., Chiodini P., Cioffi A., Guardasole V., Angelini V., Rossi A., Bilancia D., Germano D., Lamberti A., Pontillo V., Brancaccio L., Renda F, Romano F, Esani G., Gambaro A., Vinante O, Azzarello G., Clerici M., Bollina R., Belloni P., Sannicolò M., Ciuffreda L., Parello G., Cabiddu M., Sacco C., Sibau A., Porcile G., Castiglione F., Ostellino O., Monfardini S., Stefani M., Scagliotti G., Selvaggi G.,DeMarinis F.,Martelli O.,Gasparini G.,Morabito A.,Gattuso D., Colucci G., Galetta D., Giotta F., Gebbia V., Borsellino N., Testa A., Malaponte E., Capuano M.A., Angiolillo M., Sollitto F., Tirelli U., Spazzapan S., Adamo V., Altavilla G., Scimone A., Hopps M.R., Tartamella F., Ian-niello G.P., Tinessa V., Failla G., Bordonaro R., Gebbia N., Valerio M.R., D’Aprile M.,Veltri E.,Tonato M.,Darwish S.,Romito S.,Carrozza F.,Barni S., Ardizzoia A.,Corradini G.M.,Pavia G.,Belli M.,Colantuoni G.,Galligioni E., Caffo O., Labianca R., Quadri A., Cortesi E., D’Auria G., Fava S., Calcagno A., Luporini G., Locatelli M.C., Di Costanzo F., Gasperoni S., Isa L., Candido P., Gaion F., Palazzolo G., Nettis G., Annamaria A., Rinaldi M., Lopez M., Felletti R., Di Negro G.B., Rossi N., Calandriello A., Maiorino L., Mattioli R., Celano A., Schiavon S., Illiano A., Raucci C.A., Caruso M., Foa P., Tonini G., Curcio C., Cazzaniga M. Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung cancer receiving chemotherapy: a prognostic analysis of the multicenter Italian lung cancer in the elderly study. J Clin Oncol. 2005 Oct 1; 23 (28): 6865-72.
Movsas B., Moughan J., Sarna L., Langer C., Werner-Wasik M., Nicolaou N., Komaki R., Machtay M., Wasserman T., Bruner D.W. Quality of life supersedes the classic prognosticators for long-term survival in locally advanced non-small-cell lung cancer: an analysis of RTOG 9801. J Clin Oncol. 2009 Dec 1; 27 (34): 5816-22 DOI: 10.1200/JCO.2009.23.7420
Ono R., Ikeda S., Suemasu K. Hematoporphyrin derivative photodynamic therapy in roentgenographically occult carcinoma of the tracheobronchial tree. Cancer. 1992 Apr 1; 69 (7): 1696-701.
Рагулин Ю.А. Фотодинамическая терапия с фотосенсибилизаторами хлоринового ряда в комбинированном лечении центрального рака легкого . , 2007. 18 с.
McCaughan J.S., Hawley P.C., LaRosa J.C., Thomas J.H., Hicks W.J. Photodynamic therapy to control life-threatening hemorrhage from hereditary hemorrhagic telangiectasia. Lasers Surg Med. 1996; 19 (4): 492-4.
Pass H.I., Delaney T., Smith P.D., Bonner R., Russo A. Bronchoscopic phototherapy at comparable dose rates: early results. Ann Thorac Surg. 1989 May; 47 (5): 693-9.
Li J.H., Guo Z.H., Jin M.L., Zhao F.Y., Cai W.M., Gao M.L., Shu M.Y., Zou J. Photodynamic therapy in the treatment of malignant tumours: an analysis of 540 cases. J Photochem Photobiol B. 1990 Jun; 6 (1-2): 149-55.
Sutedja T., Baas P., Stewart F., van Zandwijk N. A pilot study of photodynamic therapy in patients with inoperable non-small cell lung cancer. Eur J Cancer. 1992; 28A (8-9): 1370-3.
Ono R., Egawa S., Ikeda S. Combined treatment of endoscopic laser irradiation and radiotherapy in lung cancer. Gan To Kagaku Ryoho. 1989 Apr; 16 (4 Pt 2-2): 1418-24.
LoCicero J., Metzdorff M., Almgren C. Photodynamic therapy in the palliation of late stage obstructing non-small cell lung cancer. Chest. 1990 Jul; 98 (1): 97-100.
Moghissi K., Dixon K., Stringer M., Freeman T., Thorpe A., Brown S. The place of bronchoscopic photodynamic therapy in advanced unresectable lung cancer: experience of 100 cases. Eur J Cardiothorac Surg. 1999 Jan; 15 (1): 1-6.
Яицкий Н.А., Молодцова В.П., Орлов С.В., Стельмах Л.В., Герасин В.А., Деревянко А.В., Бутенко А.Б., Уртенова М.А., Герасин А.В. Фотодинамическая терапия в лечении рака легкого. Вестник хирургии им. И.И. Грекова. 2010; 169 (5): 31-34.
Jones B.U., Helmy M., Brenner M., Serna D.L., Williams J., Chen J.C., Milliken J.C. Photodynamic therapy for patients with advanced non-small-cell carcinoma of the lung. Clin Lung Cancer. 2001 Aug; 3 (1): 37-41.
Minnich D.J., Bryant A.S., Dooley A., Cerfolio R.J. Photodynamic laser therapy for lesions in the airway. Ann Thorac Surg. 2010 Jun; 89 (6): 1744-8; discussion 1748-9 DOI: 10.1016/j.athoracsur.2010.02.025
Cardona A.F., Reveiz L., Ospina E.G., Ospina V., Yepes A. Palliative endobronchial brachytherapy for non-small cell lung cancer. Cochrane Database Syst Rev. 2008 Apr 16; (2): CD004284. CD004284.pub2 DOI: 10.1002/14651858
Stephens K.E., Wood D.E. Bronchoscopic management of central airway obstruction. J Thorac Cardiovasc Surg. 2000 Feb; 119 (2): 289-96.
Taber S.W., Buschemeyer W.C., Fingar V.H., Wieman T.J. The treatment of malignant endobronchial obstruction with laser ablation Surgery. 1999 Oct; 126 (4): 730-3; discussion 733-5.
Karanov S., Kostadinov D., Shopova M., Kurtev P. Photodynamictherapy in lung and gastrointestinal cancers. J Photochem Photobiol B. 1990 Jun; 6 (1-2): 175-81.
Furukawa K., Okunaka T., Yamamoto H., Tsuchida T., Usuda J., Kumasaka H., Ishida J., Konaka C., Kato H. Effectiveness of photodynamic therapy and Nd-YAG laser treatment for obstructed tracheobronchial malignancies. Diagn Ther Endosc. 1999;5(3):161-6 DOI: 10.1155/DTE.5.161
Santos R.S., Raftopoulos Y., Keenan R.J., Halal A., Maley R.H., Landreneau R.J. Bronchoscopic palliation of primary lung cancer: single or multimodality therapy? Surg Endosc. 2004 Jun; 18 (6): 931-6.
Diaz-Jiménez J.P., Martínez-Ballarín J.E., Llunell A., Farrero E., Rodríguez A., Castro M.J. Efficacy and safety of photodynamic therapy versus Nd-YAG laser resection in NSCLC with airway obstruction. Eur Respir J. 1999; 14 (4): 800-5.
Konaka C., Usuda J., Kato H. Preoperative photodynamic therapy for lung cancer. Nihon Geka Gakkai Zasshi. 2000 Jul; 101 (7): 486-9.
Okunaka T., Hiyoshi T., Furukawa K., Yamamoto H., Tsuchida T., Usuda J., Kumasaka H., Ishida J., Konaka C., Kato H. Lung cancers treated with photodynamic therapy and surgery. Diagn Ther Endosc. 1999; 5 (3): 155-60 DOI: 10.1155/DTE.5.155
Akopov A., Rusanov A., Gerasin A., Kazakov N., Urtenova M., Chistyakov I. Preoperative endobronchial photodynamic therapy improves resectability in initially irresectable (inoperable) locally advanced non small cell lung cancer. Photodiagnosis Photodyn Ther. 2014 Sep; 11 (3): 259-64 DOI: 10.1016/j.pdpdt.2014.03.011
Ross P., Grecula J.,Bekaii-Saab T.,Villalona-Calero M., Otterson G., Magro C. Incorporation of photodynamic therapy as an induction modality in non-small cell lung cancer. Lasers Surg Med. 2006 Dec; 38 (10): 881-9.
Perez C.A., Brady L.W. Principles and Practice of Radiation Oncology. 2nd Edition. 50-63. Philadelphia: JB Lippincott Co.; 1992. Р. 114-123.
Lam S., Kostashuk E.C., Coy E.P., Laukkanen E., LeRiche J.C., Mueller H.A., Szasz I.J. A randomized comparative study of the safety and efficacy of photodynamic therapy using Photofrin II combined with palliative radiotherapy versus palliative radiotherapy alone in patients with inoperable obstructive non-small cell bronchogenic carcinoma. Photochem Photobiol. 1987; 46 (5): 893-7.
Freitag L., Ernst A., Thomas M., Prenzel R., Wahlers B., Macha H.N. Sequential photodynamic therapy (PDT) and high dose brachytherapy for endobronchial tumour control in patients with limited bronchogenic carcinoma. Thorax. 2004 Sep; 59 (9): 790-3.
Weinberg B.D., Allison R.R., Sibata C., Parent T., Downie G. Results of combined photodynamic therapy (PDT) and high dose rate brachytherapy (HDR) in treatment of obstructive endobronchial non-small cell lung cancer (NSCLC). Photodiagnosis Photodyn Ther. 2010 Mar; 7 (1): 50-8 DOI: 10.1016/j.pdpdt.2009.12.002
Арсеньев А.И., Гельфонд М.Л., Барчук А.С., Левченко Е.В., Канаев С.В., Барчук А.А., Шулепов А.В., Веденин Я.О., Нефедов А.О. Проведение эндотрахеобронхиальных операций в комбинации с сочетанной химиолучевой терапией и фотодинамической терапией в комплексном лечении злокачественных опухолей центральных бронхов и трахеи. Сибирский онкологический журнал. 2010; 2: 7-8.
Okunaka T., Kato H., Tsutsui H., Ishizumi T., Ichinose S., Kuroiwa Y. Photodynamic therapy for peripheral lung cancer. Lung Cancer. 2004 Jan; 43 (1): 77-82.
Tomaselli F., Maier A., Sankin O., Anegg U., Stranzl U., Pinter H., Kapp K., Smolle-Juttner F.M. Acute effects of combined photodynamic therapy and hyperbaric oxygenation in lung cancer-a clinical pilot study. Lasers Surg Med. 2001; 28 (5): 399-403.
Соколов В.В., Телегина Л.В., Гладышев А.А., Соколов С.А. Клинический опыт МНИОИ им. П.А. Герцена по диагностике и эндобронхиальному лечению больных ранним центральным раком легкого. Онкология. Журнал им. П.А. Герцена. 2014; 2 (4): 4-10.

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