MTOR: сигнализация, регуляция, влияние на метаболизм, роль в регуляции продолжительности жизни и опухолевого роста

Автор: Корнилов Д.О., Тряпицын М.А., Гребнев Д.Ю.

Журнал: Известия Коми научного центра УрО РАН @izvestia-komisc

Статья в выпуске: 5 (51), 2021 года.

Бесплатный доступ

Резюме: MTOR - механическая мишень рапамицина. Путь mTOR имеет множество механизмов регуляции: гуморальный, энергетическим статусом, цитокинами и сигнальными путями MAPK. mTOR участвует в синтезе белка, в обмене глюкозы, инсулина и липидов, в метаболизме глутамина. Является важным регулятором множества неврологических и иммунных процессов. Передача сигналов mTOR вовлечена в процесс старения, в инициацию развития многих видов опухолевого роста.

Mtor, mtorc1, mtorc2, сигнализация, регуляция, метаболизм, старение, опухолевый рост

Короткий адрес: https://sciup.org/149139339

IDR: 149139339 | DOI: 10.19110/1994-5655-2021-5-104-115

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