Open-heart surgery in elderly patients: short-term vs. long-term effects

Автор: Pavel A. Khazov, Alexey D. Maystrenko, Alexander V. Gurschenkov, Elena Yu. Shvarts

Журнал: Saratov Medical Journal @sarmj

Статья в выпуске: 4 Vol.2, 2021 года.

Бесплатный доступ

The objective of the study was to analyze in-hospital mortality and long-term survival of elderly patients who underwent open-heart surgery and met the criterion of frailty. Materials and Methods. The study involved 266 patients over 75 years old complying with the frailty criterion (F-index ≤5). A total of 155 operations of coronary artery bypass grafting (CABG), 47 surgeries of aortic valve replacement (AVR), and 64 procedures of CABG in combination with AVR were performed. Study subjects were distributed among the groups depending on the surgery type. Postoperative complications were evaluated, and short-term and long-term outcomes were compared. Results. In-hospital mortality was 5.3% in general group, 9.4% in CABG+AVR group, 3.9% in CABG group, and 4.2% in AVR group. There was no significant difference among the rates of in-hospital mortality between the groups (р>0.05). Long-term survival rates in general group were as follows: 98.3% for 1-year survival, 94.6% for 3-year survival, and 82.1% for 5-year survival. Type of surgery had no significant impact on the outcome (р>0.05). Conclusion. Short- and long-term effects of CABG, AVR, and combination of CABG with AVR in the group of elderly patients who meet the criterion of frailty were characterized by low mortality and low incidence of non-fatal complications. The type of cardiac surgery and old age did not affect significantly the outcome of a surgical treatment.

Еще

Elderly, frailty, coronary artery bypass grafting, aortic valve replacement

Короткий адрес: https://sciup.org/149139016

IDR: 149139016   |   DOI: 10.15275/sarmj.2021.0405

Список литературы Open-heart surgery in elderly patients: short-term vs. long-term effects

  • Skopin II, Otarov AM, Kahkcjan PV, et al. Aortic valve replacement in old and elderly patients: Analysis of preoperative risk factors. Complex Issues of Cardiovascular Diseases 2018; (7): 24-35. [In Russ.]. https://doi.org/10.17802/2306-1278-2018-7-4S-24-35
  • Litmathe J, Feindt P, Kurt M, et al. Aortic valve replacement in octogenarians: Outcome and predictors of complications. Hellenic J Cardiol 2011; 52 (3): 211-5. https://pubmed.ncbi.nlm.nih.gov/21642069/
  • Nicolini F, Agostinelli A, Vezzani A, et al. The evolution of cardiovascular surgery in elderly patient: A review of current options and outcomes. Biomed Res Int 2014: 736298. https://doi.org/10.1155/2014/736298.
  • Sündermann S, Dademasch A, Praetorius J, et al. Comprehensive assessment of frailty for elderly high-risk patients undergoing cardiac surgery. European Journal of Cardio-Thoracic Surgery 2011; 39 (1): 33-7. https://doi.org/10.1016/j.ejcts.2010.04.013
  • Dumurgier J, Elbaz A, Ducimetiere P, et al. Slow walking speed and cardiovascular death in well functioning older adults: Prospective cohort study. BMJ 2009; (339): b4460–b4460. https://doi.org/10.1136/bmj.b4460
  • De Vries NM, Staal JB, van Ravensberg CD, et al. Outcome instruments to measure frailty: A systematic review. Ageing Research Reviews 2011; 10 (1): 104-14. https://doi.org/10.1016/j.arr.2010.09.001
  • Barreto-Filho JA, Wang Y, Dodson JA, et al. Trends in aortic valve replacement for elderly patients in the United States. JAMA 2013; 310 (19): 1999-2011. https://doi.org/10.1001/jama.2013.282437.
  • Otto CM, Nishimura RA, Bonow RO, et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease. Journal of the American College of Cardiology 2021; (143): e72-e227. https://doi.org/10.1161/CIR.0000000000000923
  • Baumgartner H, Falk V, Bax JJ, et al. ESC/EACTS Guidelines for the management of valvular heart disease. European Heart Journal 2017; 38 (36): 2739-91. https://doi.org/10.1093/eurheartj/ehx391
  • Iung B, Cachier A, Baron G, et al. Decision-making in elderly patients with severe aortic stenosis: Why are so many denied surgery? European Heart Journal 2005; 26 (24): 2714-20. https://doi.org/10.1093/eurheartj/ehi471
  • Piérard S, Seldrum S, de Meester C, et al. Incidence, determinants, and prognostic impact of operative refusal or denial in octogenarians with severe aortic stenosis. The Annals of Thoracic Surgery 2011; 91 (4): 1107-12. https://doi.org/10.1016/j.athoracsur.2010.12.052
  • Melby SJ, Zierer A, Kaiser SP, et al. Aortic valve replacement in octogenarians: Risk factors for early and late mortality. The Annals of Thoracic Surgery 2007; 83 (5): 1651-7. https://doi.org/10.1016/j.athoracsur.2006.09.068
  • Di Eusanio M, Fortuna D, De Palma R, et al. Aortic valve replacement: Results and predictors of mortality from a contemporary series of 2,256 patients. The Journal of Thoracic and Cardiovascular Surgery 2011; 141 (4): 940-7. https://doi.org/10.1016/j.jtcvs.2010.05.044
  • López-Rodríguez FJ, González-Santos JM, Dalmau MJ, Bueno M. Cardiac surgery in the elderly: comparison between medium-term clinical outcomes in octogenarians and the elderly from 75 to 79 years. Revista Española de Cardiología 2008; 61 (6): 579-88. https://pubmed.ncbi.nlm.nih.gov/18570778/
  • Likosky DS, Sorensen MJ, Dacey LJ, et al. Long-term survival of the very elderly undergoing aortic valve surgery. Circulation 2009; 120 (11suppl): S127-S133. https://doi.org/10.1161/CIRCULATIONAHA.108.842641.
  • Bossone E, Di Benedetto G, Frigiola A, et al. Valve surgery in octogenarians: In-hospital and long-term outcomes. Canadian Journal of Cardiology 2007; 23 (3): 223-7. https://doi.org/10.1016/s0828-282x(07)70749-3
  • Okamoto Y, Yamamoto K, Yoshii S. Early and late outcomes of aortic valve replacement using bioprosthetic versus mechanical valve in elderly patients: A propensity analysis. Journal of Cardiac Surgery 2016; 31 (4): 195-202. https://doi.org/10.1111/jocs.12719
  • Fukui T, Bando K, Tanaka S, et al. Early and mid-term outcomes of combined aortic valve replacement and coronary artery bypass grafting in elderly patients. European Journal of Cardio-Thoracic Surgery 2013; 45 (2): 335-40. https://doi.org/10.1093/ejcts/ezt242
  • Zheleznev SI, Isayan MV, Astapov DA, et al. The results of aortic valve replacement with a biological prosthesis, BioLAB KA/PT, in old and elderly patients. Russian Journal of Cardiology and Cardiovascular Surgery 2014; 7 (1): 54-9. [In Russ.].
  • Krane M, Voss B, Hiebinger A, et al. Twenty years of cardiac surgery in patients aged 80 years and older: Risks and benefits. The Annals of Thoracic Surgery 2011; 91 (2): 506-13. https://doi.org/10.1016/j.athoracsur.2010.10.041
Еще
Статья научная