Особенности селекции пациентов для метастаз-направленной терапии при олигометастатическом РПЖ: можно ли обойтись без системного лечения?
Автор: Волкова М.И., Аль-Акел И.С.
Журнал: Злокачественные опухоли @malignanttumors
Статья в выпуске: 3S1 т.12, 2022 года.
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Интенсификация первой линии терапии мГЧРПЖ, диагностированного de novo, привела к значимому увеличению ОВ этой категории больных. Стандартом лечения олигометастатического рака предстательной железы являются комбинации АДТ с антиандрогенами второго поколения. Совершенствование методов диагностики привело к росту доли олигометастатического рака предстательной железы (ОМРПЖ) среди впервые выявленных больных и пациентов, ранее получавших лечение. Растет доказательная база, подтверждающая позитивную роль локального лечения первичной опухоли при диссеминированном раке простаты, однако необходимы данные рандомизированных исследований для определения показаний к циторедуктивным манипуляциям. Метастаз-направленная терапия демонстрирует многообещающие результаты, однако уровень доказательной базы низок, и локальное лечение олигометастазов пока остается экспериментальным методом лечения, требует дальнейшего изучения в статистически значимых группах.
Олигометастатический рак предстательной железы, олигометастазы, метастаз-направленная терапия, рецидив рака предстательной железы
Короткий адрес: https://sciup.org/140295818
IDR: 140295818 | DOI: 10.18027/2224-5057-2022-12-3s1-62-68
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