Современные опции и перспективы системной терапии местнораспространенного и метастатического адренокортикального рака

Автор: Жуликов Ярослав А., Коваленко Елена И., Бохян Ваган Ю., Артамонова Елена В.

Журнал: Злокачественные опухоли @malignanttumors

Статья в выпуске: 3 т.11, 2021 года.

Бесплатный доступ

Адренокортикальный рак относится к орфанным опухолям и характеризуется неблагоприятным прогнозом. Комбинация химиотерапии по схеме EDP и митотана является стандартом первой линии терапии. Эффективных опций второй и последующих линий терапии не существует. Стандартом второй линии терапии является комбинация гемцитабина, капецитабина и митотана, позволяющая добиться объективного ответа у 4-7% пациентов. Достижение терапевтической концентрации митотана - важнейший предиктивный фактор эффективности второй линии терапии по схеме GemCap +митотан, в связи с чем рекомендовано продолжать терапию митотаном даже при прогрессировании на его фоне. За последние несколько лет опубликовано много исследований, посвященных изучению эффективности таргетной и иммунотерапии адренокортикального рака, однако стандарты третьей и последующей линии терапии не определены. В данном обзоре будет описаны современные представления и перспективы системной терапии местно-распространенного и метастатического адренокортикального рака.

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Адренокортикальный рак, митотан, химиотерапия, иммунотерапия

Короткий адрес: https://sciup.org/140290747

IDR: 140290747 | DOI: 10.18027/2224-5057-2021-11-3-36-44

Список литературы Современные опции и перспективы системной терапии местнораспространенного и метастатического адренокортикального рака

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