Chronotheranostics and chronotherapy - frontiers for personalized medicine

Автор: Gubin D., Weinert D., Cornelissen G.

Журнал: Тюменский медицинский журнал @tmjournal

Статья в выпуске: 1 т.22, 2020 года.

Бесплатный доступ

Ignoring the timing in the diagnostics and treatment of diseases becomes an anachronism. The expression of most genes follows a circadian rhythm. Consequently, the existence of a pronounced 24-hour variation of clinically most valuable variables means just one thing - ignorance or misunderstanding of circadian variability will inevitably lead to incorrect interpretation of the results and a high frequency of diagnostic errors. In addition, the variability of physiological functions changes with the development and progression of pathology, losing its order. Amplitude-phase parameters of the circadian rhythm are of special interest for the development of chronodiagnostic methods. On the other hand, the time of administration of a drug or other therapeutic or preventive action can critically affect its result. Decisive conditions for the breakthrough and translation of fundamental knowledge of chronobiology into practical healthcare (chronomedicine) are: 1). Development of universal criteria for the methodology of sampling, analysis and interpretation of the results of dynamic observations and 2). Development of a simple but accurate method for estimating the endogenous circadian rhythm phase. This paper presents a comparative analysis of methods for assessing the phase of circadian rhythm and considers the prospects for the implementation of chronotheranostics, the personalized chronotherapy based on chronodiagnostics.

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Circadian rhythm, circadian, biological clock, diagnosis, therapy, personalized medicine, chronotype, chronotherapy, chronotheranostics, phase, amplitude, circadian phenotype

Короткий адрес: https://sciup.org/140303363

IDR: 140303363 | DOI: 10.36361/2307-4698-2020-22-1-3-23

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