Критерии оценки эффективности неоадъювантных и адъювантных методов лечения рака молочной железы
Автор: Иванов В.Г., Жильцова Е.К., Иванова О.А., Бараш Н.Ю.
Журнал: Злокачественные опухоли @malignanttumors
Рубрика: Оригинальные статьи, собственные исследования
Статья в выпуске: 3 (7), 2013 года.
Бесплатный доступ
За последние 10 лет неоадъювантная химиотерапия заняла свое полноправное место в лечении рака молочной железы (РМЖ). Клинические исследования показали, что женщины, у которых достигнут полный патоморфологический регресс опухоли (рCR), характеризуются существенным улучшением показателей выживаемости по сравнению с теми, у кого не достигнут столь выраженный регресс. Мета-анализ, проведенный по заданию FDA (Food and Drug Administration), показал, что достижение полного патоморфологического ответа (pCR) как промежуточного маркера улучшения выживаемости, наблюдается в основном у женщин с агрессивными подтипами рака молочной железы: трижды негативным и HER2-позитивным РМЖ. У пациентов с HER2+ РМЖ дополнение трастузумаба к неоадъювантной химиотерапии удваивает частоту рCR и коррелирует с повышением показателей выживаемости.
Рак молочной железы, неоадъювантная химиотерапия, оценка эффективности лечения
Короткий адрес: https://sciup.org/14045465
IDR: 14045465
Список литературы Критерии оценки эффективности неоадъювантных и адъювантных методов лечения рака молочной железы
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