Роль Т-клеточных субпопуляций в патогенезе и терапии болезни Паркинсона (обзор литературы)

Автор: Идова Галина Вениаминовна, Альперина Елизавета Лазаревна, Жанаева Светлана Яковлевна

Журнал: Сибирский вестник психиатрии и наркологии @svpin

Статья в выпуске: 1 (118), 2023 года.

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Обзор литературы посвящен ключевой роли Т-лимфоцитов в патогенезе болезни Паркинсона (БП), изменение количества и функции которых на периферии и в головном мозге приводит к глубокому дисбалансу иммунной системы при развитии заболевания. Рассматриваются экспериментальные и клинические данные об участии провоспалительных (Тh1 и Th17) и противовоспалительных (Тh2 и Т-reg) иммунных клеток в процессе нейровоспаления и дегенерации дофаминовых нейронов. Приводятся данные о возможности использования оценки периферических Т-клеток в качестве диагностических и терапевтических биомаркеров. Обсуждаются способы модуляции Т-клеточного ответа как эффективной стратегии нейропротекции.

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Болезнь паркинсона, нейровоспаление, нейродегенерация, субпопуляции т-клеток, инфильтрация мозга, терапия

Короткий адрес: https://sciup.org/142238079

IDR: 142238079 | DOI: 10.26617/1810-3111-2023-1(118)-96-103

Список литературы Роль Т-клеточных субпопуляций в патогенезе и терапии болезни Паркинсона (обзор литературы)

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