Study of the role of the polymorphic variants of the Arg72Pro locus of the TP53 gene in the development of cervical intraepitelial neoplasia for women of the Uzbek nationality of Tashkent
Автор: Nadzhmutdinova Charming Kamaritdinovna, Kamilova Will Abdurasulovna, Pakhomova Zhanna Evgenevna, Sidikhodjaeva Mokhira Adilkhodjaevna, Baboev Kadirjon Tukhtabaevich
Журнал: Re-health journal.
Рубрика: Акушерство и гинекология
Статья в выпуске: 1 (9), 2021 года.
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When analyzing the distribution of genotypes of the Arg72Pro polymorphism of the TP53 gene among 226 patients with cervical intraepithelial neoplasia (CIN), 165 conditionally healthy women were deciphered and the prevalence of the Pro allele and the rare mutant homozygous Pro / Pro genotype over the Arg / Arg homozygous genotype was found. An increase in the severity of CIN is associated with an increase in the frequency of the rare mutant homozygous Pro / Pro genotype: in case of mild intraepithelial lesions (Lowgrade Squamous Intraepitelial Lesions (LSIL)), the frequency of the Pro / Pro genotype is 18.28% (OR = 1.422); with a high degree of squamous intraepithelial lesion (Highgrade Squamous Intraepitelial Lesions (HSIL) CIN ΙΙ 56,25% (ОR = 7,938); with HSIL CIN ΙΙΙ 75,00% (ОR = 18,522). Since the presence of the Pro allele is also associated with the progression of CIN severity, it is obvious that genotypes with the presence of this allele are risk factors for the severity of CIN.
Cervical intraepithelial neoplasia, cervical cancer, locus arg72pro, gene tp53, allele
Короткий адрес: https://sciup.org/14125508
IDR: 14125508 | DOI: 10.24411/2181-0443/2021-10001
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