Thoughts and questions arising upon the recognition of the broadly bioactive and very well tolerated antiseptic N-chlorotaurine as a highly useful medicant for prophylaxis and therapy

This report emerged from the experiences and observations of the authors who explored fundamental features of NCT and accounted for production and essential understanding of its realm of welcome properties. N-chlorotaurine (NCT) is an endogenous mild active chlorine compound, which can be synthesized chemically and applied topically as an effective anti- infective and antiseptic to different body sites. Naturally, it is produced by activated human granulocytes and monocytes during the oxidative burst. Besides the typical broad-spectrum microbicidal activity of chloramines against all kinds of microorganisms, it has anti-inflammatory properties and is involved in termination of inflammation. Because of its high tolerability and absence of systemic adverse effects due to decay to ubiquitous taurine and chloride, it can be used in sensitive body regions, too, for instance the eye, body cavities and lower airways. The latter renders NCT inhalation a promising means for the prevention and treatment of viral pneumonia including SARS-CoV-2 (Covid-19), chronic bronchitis, and cystic fibrosis. Further clinical development is urgently needed to characterize the preventive and therapeutic effects in detail. Particularly the time of the present pandemic confirmed how difficult recognition and support of innovations frequently is.