Cellular immunity in children with psoriasis

The article considers the issues of studying the features of cellular immunity in children of preschool age with psoriasis, before and after therapy. The study included 28 children suffering from psoriasis aged 3 to 6 years. The control group for comparison consisted of 12 healthy children of the same age and gender. In this research, personal and family history of patients were thoroughly studied, and general clinical examinations were conducted. Also, in order to determine some indicators of cellular immunity (CD3+, CD4+, CD8+, CD16+ and CD20+), immunological methods were used. Thus, the results of the study showed that in preschool children suffering from psoriasis, there is a decrease in the total number of T-lymphocytes (CD3+), T-helper cells (CD4+), T-suppressors (CD8+), and an increase in B-lymphocytes (CD20+), natural killer cells (CD16+) and immunoregulatory index. After the treatment, an increase in the level of CD3+, CD20+, CD4+ and CD8+ immunoregulatory lymphocyte subpopulations is noted. Simultaneously, the inclusion of immunomodulating therapy leads to the normalization to the control values of the indices CD4+ and CD8+ of immunoregulatory lymphocyte subpopulations.