Correction of the functional state of female rats after unilateral ovariectomy using a succinate containing composition
Автор: Vasilieva Anna A., Simonova Maria A., Bairamov Alekber A., Grishina Elena V, Uchitel Mikhail L., Maevsky Eugene I.
Журнал: Cardiometry @cardiometry
Рубрика: Original research
Статья в выпуске: 10, 2017 года.
Бесплатный доступ
Unilateral ovariectomy (UOE) of female rats caused an increase in duration of the non-reproductive period (NRP) - metestrus and diestrus phases, and shortening of the reproductive period (RP) - proestrus and estrus phases of the estrous cycle (a symptom of hormonal deficiency). Signs of stress persisted 5 weeks after UOE: reduction of the ratio of thymus weight to the weight of adrenal glands (T/A). A two-week course of the succinate-containing composition with added B vitamins (SCCV) administered to the control female rats and those upon UOE has increased the T/A ratio as compared to that of intact animals, which is an indication of “activation” according to Garkavi et al. [1] and restored the NRP/RP ratio. Cytobiochemical analysis found a significant increase in nitroblue tetrazolium reduction during succinate oxidation in lymphocytes according to reading of animal blood smears.
Unilateral ovariectomy, succinate containing composition, estrous cycle, stress, cytobiochemical analysis
Короткий адрес: https://sciup.org/148308826
IDR: 148308826 | DOI: 10.12710/cardiometry.2017.8692
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