Differential diagnosing with MRI patterns of CNS lesion in NMOSD

Opticomyelitis or Devik's disease is an autoimmune progressive demyelinating disease of the central nervous system, with a predominant lesion of the optic nerves and spinal cord, which can lead to both loss of vision and death. One of the common causes of mortality in this disease is the difficulty associated with the differential diagnosis of opticomyelitis with multiple sclerosis. A distinctive difficulty in diagnosis is the clinical cases of opticomyelitis in which periventricular asymptomatic foci in the brain can be detected. Their clinic and laboratory data can be very similar, but they need to be differentiated among themselves in the selection of therapy, since the drugs used for multiple sclerosis are not only ineffective in patients with opticomyelitis, but can even cause an increase in the frequency of exacerbations. Due to the reasons for the high disability of patients (blindness: in at least one eye in 50% of patients with recurrent and 25% of patients with a monophasic form of the disease) and mortality, the optimization of clinical trial methods is still an urgent issue. To date, there are already the main diagnostic methods for Opticomyelitis developed by the international team for the diagnosis of Opticomyelitis. That is why the integration of these methods into the realities of Uzbekistan is an extremely important task.