Генетические корреляты когнитивных нарушений при шизофрении (обзор литературы)

Автор: Янушко Мария Григорьевна, Сосин Дмитрий Николаевич, Шаманина Мария Валерьевна, Иванов Михаил Владимирович

Журнал: Сибирский вестник психиатрии и наркологии @svpin

Статья в выпуске: 2 (99), 2018 года.

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Шизофрения представляет собой гетерогенное психическое расстройство с достаточно высокой степенью наследуемости. Наряду с позитивными, негативными и аффективными нарушениями когнитивный дефицит является одним из основных нарушений при шизофрении. В настоящее время активно разрабатывается направление поиска промежуточных фенотипов психических расстройств. Эндофенотип представляет собой промежуточный фенотип, лежащий между генетическими предпосылками психического расстройства и комплексом симптомов. Когнитивный дефицит при шизофрении можно рассматривать в качестве эндофенотипа. Учитывая тот факт, что когнитивные функции имеют высокую степень наследуемости, на сегодняшний день большое количество генов рассматривается в качестве кандидатов на роль ответственных за когнитивный дефицит при шизофрении. Дальнейшие исследования в этой области должны пролить свет на этиологию психически расстройств, механизм формирования когнитивного дефицита при шизофрении, а также помочь разработке новых препаратов, улучшающих когнитивные функции.

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Шизофрения, когнитивный дефицит, эндофенотип, полиморфизмы генов, биомаркер, психическое расстройство

Короткий адрес: https://sciup.org/142212926

IDR: 142212926 | DOI: 10.26617/1810-3111-2018-2(99)-105-110

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