Клеточные технологии в лечении заболеваний легких – есть ли перспективы?

Автор: Аверьянов Александр Вячеславович, Коноплянников Анатолий Георгиевич

Журнал: Клиническая практика @clinpractice

Статья в выпуске: 4 (4), 2010 года.

Бесплатный доступ

В статье анализируется состояние проблемы лечения патологии легких с применением клеточных технологий. Приведены результаты исследовательских, преимущественно экспериментальных работ в данной области, дающих надежды на положительные исходы клинических исследований у человека. Рассматриваются возможные механизмы влияния стволовых клеток на регенеративные процессы в легких.

Стволовые клетки, эмфизема легких, фиброз легких, легочная гипертензия, рак легких

Короткий адрес: https://sciup.org/14338348

IDR: 14338348

Список литературы Клеточные технологии в лечении заболеваний легких – есть ли перспективы?

Joyce N., Annett G., Wirthlin L. et al. Mesenchymal stem cells for the treatment of neurodegenerative disease//Regen. Med. 2010. Vol. 5 (6). P. 933-946.
Wen Y., Chen B., Ildstad S.T. Stem cell-based strategies for the treatment of type 1 diabetes mellitus//Expert Opin. Biol. Ther. 2011. Vol. 11 (1). P. 41-53.
Hodgkinson C.P., Gomez J.A., Mirotsou M., Dzau V.J. Genetic engineering of mesenchymal stem cells and its application in human disease therapy//Hum. Gene Ther. 2010. Vol. 21 (11). P. 1513-1526.
Sullivan S., Cowan C., Eggan K. (Eds.) Human embryonic stem cells. A John Wiley & Sons, Ltd., Chennai, 2007. 404 pp.
Lakshmipathy U. et al. (Eds.) Emerging technology platforms for stem cells. A John Wiley & Sons, Inc., New Jersey, 2009, 506 pp.
Battler A., Leor J. (Eds.) Stem cells and gene-based therapy. Frontiers in regenerative medicine. Springer, 2006. 422 pp.
Zhen G., Liu H., Gu N., Zhang H. Mesenchymal stem cells transplantation protects against rat pulmonary emphysema//Front Biosci. 2008. Vol. 13. P. 3415-3422.
Zhen G., Xue Z., Zhao J. et al. Mesenchymal stem cell transplantation increases expression of vascular endothelial growth factor in papain-induced emphysematous lungs and inhibits apoptosis of lung cells//Cytotherapy. 2010. Vol. 12 (5). P. 605-614.
Schweitzer K., Johnstone B.H., Garrison J. et al. Adipose stem cell treatment in mice attenuates lung and systemic injury induced by cigarette smoking//Am. J. Respir. Crit. Care Med. 2011. Vol. 183 (2). P. 215-225.
Sala E., Villena C., Balaguer C. et al. Abnormal levels of circulating endothelial progenitor cells during exacerbations of COPD//Lung. 2010. Vol. 188 (4). P. 331-338.
Palange P., Testa U., Huertas A. et al. Circulating haemopoietic and endothelial progenitor cells are decreased in COPD//Eur. Respir. J. 2006. Vol. 27 (3). P. 529-541.
Huertas A., Testa U., Riccioni R. Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI//Respir. Physiol. Neurobiol. 2010. Vol. 170 (1). P. 23-31.
Ishizawa K., Kubo H., Yamada M. et al. Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema//FEBS Lett. 2004. Vol. 556 (1-3). P. 249-252.
Kotton D.N., Ma B.Y., Cardoso W.V. et al. Bone marrow-derived cells as progenitors of lung alveolar epithelium//Development. 2001. Vol. 128 (24). P. 5181-5188.
Spees J.L., Pociask D.A., Sullivan D.E. et al. Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis//Am. J. Respir. Crit. Care Med. 2007. Vol. 176 (4). P. 385-394.
Moodley Y., Ilancheran S., Samuel C. Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair//Am. J. Respir. Crit. Care Med. 2010. Vol. 182 (5). P. 643-651.
Moodley Y., Atienza D., Manuelpillai U. et al. Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury//Am. J. Pathol. 2009. Vol. 175 (1). P. 303-313.
Курсова Л.В., Конопляников А.Г., Пасов В.В. и др. Возможности применения аутологичных мезенхимальных стволовых клеток в лечении лучевых повреждений легких//Клеточные технологии в биологии и медицине. 2009. Т. 6б № 2. С. 108-112.
Rochefort G.Y., Delorme B., Lopez A. Multi-potential mesenchymal stem cells are mobilized into peripheral blood by hypoxia//Stem Cells. 2006. Vol. 24 (10). P. 2202-2208.
Firth A.L., Yao W., Ogawa A. Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension//Am. J. Physiol. Cell Physiol. 2010. Vol. 298 (5). P. C1217-C1225.
Umar S., de Visser Y.P., Steendijk P. Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension//Am. J. Physiol. Heart Circ. Physiol. 2009. Vol. 297 (5). P. H1606-H1616.
He Z.X., Wang H.W., Shang F. et al. Administrating bone marrow mesenchymal stem cells to treat the experimental pulmonary arterial hypertension in rats//Zhonghua Yi Xue Za Zhi. 2009. Vol. 89 (30). P. 2110-2115.
Kanki-Horimoto S., Horimoto H., Mieno S. et al. Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension//Circulation. 2006. Vol. 114 (1 Suppl). P. I181-I185.
Mao M., Wang S.N., Lv X.J. et al. Intravenous delivery of bone marrow-derived endothelial progenitor cells improves survival and attenuates lipopolysaccharide-induced lung injury in rats//Shock. 2010. Vol. 34 (2). P. 196-204.
Lam C.F., Liu Y.C., Hsu J.K. Autologous transplantation of endothelial progenitor cells attenuates acute lung injury in rabbits//Anesthesiology. 2008. Vol. 108 (3). P. 392-401.
Lee J.W., Fang X., Gupta N. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung//Proc. Natl. Acad. Sci. USA. 2009. Vol. 106 (38). P. 16357-16362.
Xu J., Woods C.R., Mora A.L. et al. Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice//Am. J. Physiol. Lung Cell Mol. Physiol. 2007. Vol. 293. P. L131-L141.
Ерохин В.В., Цыб А.Ф., Чуканов В.И. и др. Клеточные технологии в терапии хронического мультирезистентного туберкулеза легких//Проблемы туберкулеза и болезней легких. 2006. № 8. С. 3-5.
Васильева И.А., Коноплянников А.Г., Ерохин В.В. и др. Лечебный эффект системной трансплантации культивируемых аутогенных мезенхимальных стволовых клеток костного мозга у больных с резистентными формами туберкулеза легких//Клеточная трансплантология и тканевая инженерия. 2007. Т. 4 (1). С. 77-80.
Maurya D.K., Doi C., Kawabata A. et al. Therapy with un-engineered naive rat umbilical cord matrix stem cells markedly inhibits growth of murine lung adenocarcinoma//BMC Cancer. 2010. Vol. 10. P. 590.
Loebinger M.R., Kyrtatos P.G., Turmaine M. Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles//Cancer Res. 2009. Vol. 69 (23). P. 8862-8867.
Loebinger M.R., Eddaoudi A., Davies D., Janes S.M. Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer//Cancer Res. 2009. Vol.69 (10). P. 4134-4142.
Grisendi G., Bussolari R., Cafarelli L. Adipose-derived mesenchymal stem cells as stable source of tumor necrosis factor-related apoptosis-inducing ligand delivery for cancer therapy//Cancer Res. 2010. Vol. 70 (9). P. 3718-3729.
Eramo A., Lotti F., Sette G. et al. Identification and expansion of the tumorigenic lung cancer stem cell population//Cell Death Differ. 2008. Vol. 15. P. 504-514.
Mimeault M., Hauke R., Metha P.P., Batra S.K. Recent advances in cancer stem/progenitor cell research: therapeutic implications to overcome resistance to the most aggressive cancers//J. Cell Mol. Med. 2007. Vol. 11. P. 981-1011.
Jeon E.S., Lee I.H., Heo S.C. Mesenchymal stem cells stimulate angiogenesis in a murine xenograft model of A549 human adenocarcinoma through an LPA1 receptor-dependent mechanism//Biochim. Biophys. Acta. 2010. Vol. 1801 (11). P. 1205-1213.
Krause D.S., Theise N.D., Collector M.I. et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell//Cell. 2001. Vol. 105. P. 369-377.
Kotton D.N., Ma B.Y., Cardoso W.V. et al. Bone marrow-derived cells as progenitors of lung alveolar epithelium//Development. 2001. Vol. 128. P. 5181-5188.
Wang G., Bunnell B.A., Painter R.G. et al. Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis//Proc. Natl. Acad. Sci. USA. 2005. Vol. 102. P. 186-191.
Kotton D.N., Fabian A.J., Mulligan R.C. Failure of bone marrow to reconstitute lung epithelium//Am. J. Respir. Cell Mol. Biol. 2005. Vol. 33. P. 328-334.
Loi R., Beckett T., Goncz K.K. et al. Limited restoration of cystic fibrosis lung epithelium in vivo with adult bone marrow-derived cells//Am. J. Respir. Crit. Care Med. 2006. Vol. 173. P. 171-179.
Lee J.W., Gupta N., Serikov V. Potential application of mesenchymal stem cells in acute lung injury//Expert. Opin. Biol.Ther. 2009. Vol. 9 (10). P. 1259-1270.
Rasmusson I., Le Blanc K., Sundberg B., Ringden O. Mesenchymal stem cells stimulate anti-body secretion in human B cells//Scand. J. Immunol. 2007. Vol. 65. P. 336-343.
Raffaghello L., Bianchi G., Bertolotto M. et al. Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche//Stem Cells. 2008. Vol. 26 (1). P. 151-162.
Roomans G.M. Tissue engineering and the use of stem/progenitor cells for airway epithelium//Eur. Cell Mater. 2010. Vol. 19. P. 284-299.
www. ClinicalTrials.gov

Еще

Статья научная