Статьи журнала - Cardiometry
Все статьи: 606
The G.Poyedintsev - O. Voronova mathematical model of hemodynamics
Отчет
Aims The objective is to demonstrate the features of an original mathematical model of hemodynamics, developed by Russian researchers G.Poyedintsev and O.Voronova. Materials and methods The proposed original mathematical model of hemodynamics is based on the laws of the fresh hydrodynamic theory of the "third" fluid flow mode. Results As a result of the application of the above mathematical model of hemodynamics, an advanced method for noninvasive measuring of a complete set of hemodynamic parameters with the use of the cardiac cycle phase durations, implemented by the Cardiocode device, have been elaborated. Conclusion The unique method for noninvasive measuring of a complete set of hemodynamic parameters, which has been developed on the basis of the above mathematical model of hemodynamics, is a promising source for considerable expanding of diagnostics capabilities.
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It has long been thought who wants to be healthy and strong should go in for sports: do exercises, run, swim, participate in sports games and so on. Speaking about amateur sporting participants, the result of being vigorous, energetic, able-bodied and physically & emotionally attractive is important for us.
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The course of very severe aortic stenosis due to bicuspid aortic valve calcinosis in a young man
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In the young patients with bicuspid aortic valve, manifestation of aortic stenosis (AS) often remains silent. Asymptomatic very severe AS makes medical decisions challenging. For the better evaluation of AS severity and estimation the indications for the surgical treatment any stress test is preferable. We report a case history of a 46 year old male patient with successfully treated critical AS with severe heart failure (HF) that demonstrates effectiveness of the surgical treatment. Successful aortic valve replacement (AVR) was beneficial and guided to increase functional class, improve LV systolic function, normalization of the heart chambers, decreased pulmonary hypertension (PH), determined reversible left ventricle (LV) hypertrophy. Summarizing our experience, we hypothesize that surgical treatment of this patient with asymptomatic very severe AS would be helpful in increasing quality of life and avoiding manifestation of AS with critical severe HF.
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The effect made by the vaginal microbiome on pregnancy outcome
Статья научная
This article considers the effect made by the vaginal microbiome on the outcome of pregnancy. The vaginal microbiome is important for the health of a woman’s reproductive system and can affect some critical aspects of pregnancy such as the development of preeclampsia and the likelihood of premature birth. This study is based on an analysis of the composition of the microbiome in pregnant women and the correlation of the data obtained with the outcomes of their pregnancy. The results of the study can help in the development of new approaches to predictive diagnostics and treatment of possible pregnancy complications caused by changes in the vaginal microbiome.
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Статья научная
The aim is to study the effect of comorbid pathology, namely, diabetes mellitus, on free radical oxidation in the mitochondria in the heart cells in female rats with experimental Guerin carcinoma.
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Статья научная
The aim of present study was to compare the effect of Ca chelating anticoagulants (EDTA, citrate and oxalate) and antithrombin anticoagulant (heparin) on some rabbits plasma biochemical parameters at room temperature 25°С and extreme temperatures -18°С and 50°С for 1hr. Five male rabbits weighting between 800-1000gm, kept in the animal house /College of Veterinary Medicine/University of Diyala, under 12:12 dark light cycle with ad libtum food and water in individual cages (60cm,40cm) during November and December /2022. Four ml of blood samples were collected by cardiac puncture (23G needle) into four tubes contain anticoagulants: (EDTA, citrate, oxalate and heparin)one ml of blood for each tube; then the blood samples were kept at :room temperature 25°С, waterbath 50°С and refrigerator -18°С, for 1hr then put in centrifuge at 3000rpm for 15min. From total examined blood samples =24 for each Ca chelating anticoagulants (EDTA, citrate and oxalate) and antithrombin anticoagulant (heparin) after 1hr under in 25c°С, -18°С and 50°С. The both groups of anticoagulants (Ca chelating and antithrombin) showed no significant differences P>0.05 between them in level of biochemical parameters (glucose, total protein, cholesterol and urea) after 1 hr at 25C; on the other hand significant increase in plasma glucose, total protein and cholesterol beside significant decrease in plasma urea of Ca chelating anticoagulants after 1hr at -18C and 50C as compare with antithrombin anticoagulant. In conclusion; heparin was more effective than Ca chelating anticoagulant in preserve plasma biochemical parameters within normal values under extreme cool and hot condition
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Статья научная
The aim of present study was to compare the effect of Ca chelat-ing anticoagulants (EDTA, citrate and oxalate) and antithrombin anticoagulant (heparin) on some rabbits plasma biochemical pa-rameters at room temperature 25 °С and extreme temperatures -18 °С and 50 °С for 1hr. Five male rabbits weighting between 800-1000gm, kept in the animal house /College of Veterinary Medicine/University of Diyala, under 12:12 dark light cycle with ad libtum food and water in individual cages (60cm,40cm) during November and December /2022. Four ml of blood samples were collected by cardiac puncture (23 G needle) into four tubes con-tain anticoagulants: (EDTA, citrate, oxalate and heparin)one ml of blood for each tube; then the blood samples were kept at :room temperature 25 °С, waterbath 50 °С and refrigerator -18 °С, for 1hr then put in centrifuge at 3000 rpm for 15 min. From total ex-amined blood samples =24 for each Ca chelating anticoagulants (EDTA, citrate and oxalate) and antithrombin anticoagulant (hep-arin) after 1hr under in 25 °С, -18 °С and 50 °С. The both groups of anticoagulants (Ca chelating and antithrombin) showed no significant differences P>0.05 between them in level of biochem-ical parameters (glucose, total protein, cholesterol and urea) after 1 hr at 25 °С; on the other hand significant increase in plasma glucose, total protein and cholesterol beside significant decrease in plasma urea of Ca chelating anticoagulants after 1hr at -18 °С and 50 °С as compare with antithrombin anticoagulant. In con-clusion; heparin was more effective than Ca chelating anticoag-ulant in preserve plasma biochemical parameters within normal values under extreme cool and hot condition
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Статья научная
The prudent utilization of (N2O/O2) can offer a secure and efficient method to manage dental anxiety in children, adolescents, and individuals with specific healthcare requirements. Application of nitrous oxide for pain and anxiety alleviation in pediatric dentistry patients. One of these optimal methods is to furnish dentists with guidance on the secure and efficient use of nitrous oxide/oxygen (N2O/O2). Analgesia and anxiety alleviation particularly designed for pediatric patients. The recommendations for the use of (N2O/ O2) focus on the objectives, overall factors to consider, situations where it is appropriate, and situations where it should be avoided, for the purpose of managing sedation/anxiety. Before using ( N2O/O2) to treat pediatric patients, several factors should be taken into account. These include the patient’s physical and emotional development, medical and dental history, and the specific dental treatment required. It is also important to consider alternative behavioral guidance options, as well as the credentials and training of the dentist and other dental personnel. The availability of appropriate equipment and facilities, as well as the implementation of management and use monitoring techniques, should also be considered. Additionally, potential harmful effects and consequences, as well as occupational safety, need to be carefully evaluated. The documentation about its utilization is being discussed. The investigation was done on two cohorts of children in public and private clinics. The findings revealed reduced liver function and vitamin B12 levels in children who were exposed to nitrous oxide, as compared to the group of healthy children.
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Статья
Over the past decade, the use of adoptive immunotherapy has emerged as a promising approach to treatment of various malignancies, including breast cancer. Cytokines are involved in the development, differentiation and homeostasis of the T cells. Despite the similarities in signaling pathways, the γc cytokines shape the T cell responses differently: IL-2 plays a major role in the development and maintenance of the regulatory T cells, while IL- 15 stimulates the proliferation and cytotoxic functions of the CD8+ T cells and NK- cells that leads to an enhanced antitumor response. It is of interest to study the combined effect of these cytokines in an experiment.
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The effects of essential oils and music on the bioelectrical activity in brain
Статья научная
We studied the effect of essential oils and music fragments, as well as their various combinations on the brain’s electrical activity parameters. We showed the character of their impact on the basic EEG frequency bands, identified localization of sources for specific activity. It was found that the olfactory and musical influence of different modalities have unidirectional effect on the bioelectric activity indices. This EEG response is most likely associated with a common mechanism for implementing the effects of audio and odorant stimulants. It was found that the response to the combinations of sensory effects has different intensity. These data permit the sensory effects to be ranked in terms of their activation level, which makes it possible to purposefully influence the psycho-emotional states. Our findings are the basis for developing further methods and programs of modifying the athletes’ functional states
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The article presents the results of space experiment “Pneumocard”. The investigation involved all 25 Russian members of the ISS crew. The total of 226 sessions were made including 130 aboard the ISS, 50 prior to launch and 46 on return from mission. The objective was to study effects of the spaceflight factors on autonomic regulation of blood circulation, respiration and cardiac contractility during long-duration mission. The purpose was to secure new research data that would clarify our present view of adaptation mechanisms. Registered were the following signals: electrocardiogram, impedance cardiogram, seismic cardiogram, pneumotachogram, finger photoplethysmogram. A set of hard- and software was used. Autonomic regulation of blood circulation by HRV analysis was investigated. It was shown that at the onset of a space mission parasympathetic involvement in regulation increases typically with subsequent mobilization of additional functional reserve. It guided the development of a functional states mathematical model incorporating the established types of autonomic regulation. Our data evidence that the combination of HRV analysis, pre-nosology diagnosis and probabilistic estimate of the pathology risk can reinforce the medical care program in space missions.
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The immune system and malignant neoplasms: fundamental and translational aspects
Статья
The immune system is responsible for control of the antigenic continuity, ensuring the friend-orfoe identification and the formation of appropriate responses by the organism, aimed either at destruction (in case of infection with infectious pathogens and transplantation of an alien graft), or protection of the "foe" to be incorporated by the host organism (under physiological pregnancy, or in case of pathology under malignant growth) [1]. The immune system closely interacts with the DNA Damage Response (DDR) system, which, together with other signaling pathways, ensures the repair of damaged genetic material. In the presence of a defect in the repair system, for example, with congenital mutations in the BRCA 1/2 repair genes, genomic instability appears as a basis for the development of cancer. This determines clonal evolution through an accumulation of driver aberrations (CNA, chromosomal rearrangements, mutations), malignancy, and progression of a malignant process, primarily associated with distant metastases [2].
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Статья научная
Background: Patients with congenital heart disease (CHD), particularly those with single ventricular physiology undergoing Glenn shunt, often experience limited functional capacity and decreased quality of life (QoL). This study evaluates the impact of a 12-week cardiac rehabilitation (CR) program on functional capacity, measured by the 6-minute walk test (6MWT), and QoL in post-Glenn (PG) patients.
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Статья научная
Background Implantation of multiple (≥ 2) overlapping stents has been associated with adverse outcomes after percutaneous coronary intervention (PCI). However, data regarding the impact of multiple new generations drug-eluting stents (DES) during primary PCI (PPCI) are limited. Objective To evaluate the impact of multiple overlapping stents implantation on the 6-months clinical outcomes of anterior STEMI patients undergoing PPCI with new generations DES. Methods We evaluated a total of 1078 consecutive anterior STEMI patients who underwent PPCI with deployment of new generations DES. The patients were divided according to the number of implanted stents into 2 groups; multiple-stents group having ≥2 overlapping stents (n =388) and single-stent group (n =690). We compared the rates of major adverse cardiovascular events (MACEs; composite of cardiac death, reinfarction, ischemia-driven target vessel revascularization (TVR), definite stent thrombosis (ST), and stroke) between the 2 study groups. Results There was a non-significant trend toward increased in-hospital mortality in the multiple-stents group [3.4% vs 1.7%; P=0.096]related to a significant higher rate of cardiogenic shock [9.5% vs 6.1%; P=0.037] and post-procedural suboptimal TIMI flow [26.3% vs 19.4%; P=0.009] as compared to the single-stent group. Yet, there were no significant differences between the 2 groups in the incidence of 6-month MACEs: [9% vs 7.1%; P=0.259], cardiac death: [4.6% vs 3%; P=0.173], reinfarction: [3.6% vs 3.2%; P=713], TVR: [4.4% vs 4.1%; P=0.799], and definite ST: [3.6% vs 2.8%; P=0.43], respectively. Conclusion The use of multiple new generations DES, if needed, is relatively safe and acceptable during PPCI for STEMI patients.
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The impact of rock music on Indian young adults: a qualitative study on emotions and moods
Статья научная
Music has proven to play a vital role in social and emotional development in teenagers and young adults. From contemplation, developing self-identity, understanding interpersonal relationships, and providing possibilities of experience mastery, agency, and self-control with the help of self-directed activities, music helps its audience develop in all aspects of life. In specific, Rock music, since its existence has been more than entertainment, artists expressed themselves and shared their opinions through their musical pieces. Infamous for promoting drugs and alcohol, Rock Music used its platform to enlighten the audience about taboo topics like racism, inequality, and other social issues. This research paper uses a qualitative methodology approach to understand Rock Music listeners’ points of view. Data was collected through ‘in-depth interviews’ of 15 participants hailing from different parts of the country. Rock Music has several positive effects on the listeners. Rock can elevate moods, induce emotions, helps the listeners be more productive and creative with their everyday work, and constantly motivate them to do better in every aspect of life. Rock provides a platform to express feelings and vent out all the angst, especially for those who otherwise do not voice their opinions because of their nature in general. Rock Music has been able to shape personalities, characteristics, and thought processes. Moreover, majorly, Rock Music helps people with anger management.
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Статья научная
The article discusses the promising possibilities of using the method of volumetric compression oscillometry in clinical practice, which allows to simultaneously determining 20 indicators of central hemodynamics. A comparative analysis with other research methods is presented herein, and the advantages of the presented method in the diagnostics of cardiovascular diseases are shown. The problematic issues in using this method and ways to solve them are considered herein.
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Статья научная
The aim is to assess the incidence rate of arterial hypertension (AH) and high normal arterial pressure (HNAP) in students of the Medical Faculty at the Kabardino-Balkarian State University as well as the relationship between arterial pressure (AP) and behavioral and biological risk factors (RF) of cardiovascular diseases (CVD) to substantiate the need for preventive measures
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Статья
Melanoma is the most aggressive of the common forms of skin cancer. Proinflammatory cytokines produced by the tumor and delivered via the circulatory and lymphatic systems can lead to damage to the structures of the central nervous system. Damage to the blood-brain barrier and the endothelium of blood capillaries can cause dysfunction of neurons in the cerebral cortex, induce changes in neural plasticity, cognitive functions and result in the development of depression. Depression is observed in 20% of the cancer patients, and it affects quality of life, treatment effectiveness and survival. Depression has been linked to damage to the prefrontal cortex, which plays an important role in many brain functions, including cognition, emotion regulation, motivation and sociability.
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Статья научная
With the participation of 8 male volunteers, the dynamics of values of heart rate autonomic regulation were studied at response to physical load on a bicycle ergometer twice: both respirating by the room air under normobaric environment and simulating effects of the altered hyperoxic respiratory gas mixture (HRGM) by the rebreathe respiration methods from a rebreather at the high-pressure chamber (at «depth» 7 m). The devices and methods of Holter electrocardiogram monitoring were used under 24 hours research. The specialized software to analyze the data was used. The electrocardiogram (ECG) and calculated time series of cardiac intervals data obtained were subjected to mathematical processing to calculate statistical and spectral values of heart rate variability (HRV). Additionally, the geometric and nonlinear analysis methods of HRV were investigated. It has been established that influencing factors (compound and pressure of the HRGM) affect the autonomic regulation of heartbeats both at rest and during physical load. Clinical practitioners the HRV values are studied at rest and during strictly regulated tests, i.e. in stationary conditions.non-stationary processes, for example, when it is necessary to continuously analyze data, the so-called transient processes under increasing psychological stress, to assess changes in the autonomic regulation of the heart during breathing of gas mixtures with different compositions (hypoxic therapy, hyperbaric oxygenation, etc.), and, especially during physically upload are used the methods of nonlinear and geometric analysis of HRV that are independent of the degree of nonstationary processes and, to some extent, of artifactual cardiac intervals. During the breathing the respiratory gas mixtures with an increased substance of O2 under conditions of high pressure, the activity of the parasympathetic branches of the autonomic nervous system (ANS) significantly increases. The nonlinear dynamics indexes reflect significant differences in the activity of autonomic components under experimental conditions in the direction of strengthening the parasympathetic links of the ANS. The use of nonlinear analysis values is more acceptable when evaluating obtained of non-stationary processes. In general, the study confirms that the regulatory response to the effects of hyperbaria and hyperoxia when performing a bicycle ergometer test with stepwise increase exercise strain is manifested by the prevalence of the activity of the parasympathetic part of the ANS autonomic regulation of cardiac rhythm compared to regular room air and barometric pressure.
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Статья научная
The article is devoted to the study of the cardiovascular system indicators in students under the conditions of exam stress. As a result we have found that students have experienced severe stress before the examination and after it that has negatively affected their hemodynamic parameters, which have shown high values indicating overstrain of the adaptation mechanisms
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