Статьи журнала - Cardiometry
Все статьи: 606
Статья научная
The low efficacy of ongoing conventional therapy and a significant decrease in the quality of life in patients with reconstructive plastic surgery (RPO) on the pelvic organs (PO) due to tubal-peritoneal infertility (TPI) and chronic nonspecific salpingo-oophoritis (CNSO) requires searching for new, promising methods of non-drug treatment, in particular, taking into account the regional characteristics of the Republic of North Ossetia-Alania and its natural resources. One of the main ways to increase the efficacy and intensify the treatment of this category of patients is the use of natural factors, namely, sulfide waters of the local Redant-4 deposit, which have a number of anti-inflammatory effects. Purpose of the study is to assess the role of non-drug technologies using magnetic infrared-laser therapy and balneological factors of the local deposit in the rehabilitation of the reproductive function in patients undergoing reconstructive plastic surgery due to TPI and CNSO. Material and methods. 235 women with impaired reproductive function, who underwent laparoscopic reconstructive plastic surgery on the pelvic organs (RPO on PO) due to tubal-peritoneal infertility (TPI) and CNSO, whose average age was 28 + 7 years, were examined. 2 groups were formed by the method of blind sampling: the main group consisted of 139 women with RPO on the pelvic organs due to TPI and CNSO, who, along with conventional therapy, received magnetic IR-laser therapy and had hydrogen sulfide baths; the comparison group included 96 women with RPO on PO due to TPI and CNSO, whose treatment was carried out by conventional methods of drug therapy. The conventional treatment included along with antibiotic therapy the use of ecological adaptogens (aloe, apilac), immune modulators (polyoxidonium), vitamin therapy (vitamin E 100 mg / day for 3 months and B vitamins), drugs to eliminate disorders in the intestinal and vaginal flora (antifungal agents: fluconazole, tergynan, acylact for 7-14 days). The patients of the studied groups were observed before their treatment and 1-12 months after the treatment. All patients underwent a clinical and functional examination. Statistical processing of the material was carried out using the package Statistica for Windows. Results. A control examination of patients of both groups showed a more pronounced positive effect on the course of a number of clinical symptoms in the postoperative period in the main group of patients who received magnetic IR laser therapy and had sulfide baths of the North Ossetian deposit in the complex of therapy. As a result of the physiotherapy treatment, the pain syndrome was eliminated in 107 of 139 patients (77%) who complained of pain before their treatment. A decrease in pelvic pain after the course of treatment was noted in 46 patients (33%). It should be noted that in the majority of patients 94 (68%), who received sulfide balneotherapy, a decrease in the formation of repeated adhesions of the pelvis was revealed during the procedures, the effectiveness of the regression of the adhesive process was found throughout the observation. It was detected that against the background of the proposed non-drug technology in the rehabilitation treatment of patients with RPO on PO due to TPI and CNSO, a significant increase in the effectiveness of treatment of this pathology (89%), improvement in the quality of life of patients as well as restoration of fertility has been achieved. Conclusions. The use of the method of sulfide balneotherapy in patients with RPO on PO due to TPI and CNSO allows shortening the duration of their next treatment and achieving the maintenance of positive dynamics and duration of regression of the adhesive process of the pelvis.
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The role of nutritional restriction in the pathogenesis of malignant tumors
Статья
Cancer is one of the leading causes of death in developed countries. Cancer incidence is growing, and it may be associated with longer life expectancy that leads to higher risk of cancer development. Metabolic changes are among the most important aspects of the tumor progression, which appear both in the tumor cells themselves and in the tumor microenvironment, affecting later the entire organism as a whole. Abnormal metabolism of tumor cells, including activation of aerobic glycolysis and enhancement of anabolic pathways, is important in metastasizing, medical drug resistance, and in the implementation of tumor stem cell viability programs [2]. In this context, a priority is given to studies aimed at the inhibition of enzymes of metabolic processes by small molecules or some exogenous factors. Overcoming metabolic plasticity is one of the strategic goals in anticancer therapy [3].
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The role of pacemaker algorithms in preventing atrial fibrillation progression
Статья научная
Background: Unnecessaryright ventricular (RV) pacing leads to cardiac dyssynchrony and increases the risk of developing permanent atrial fibrillation. Minimizing RV pacing by specefic algorithms decreases the AF risk. Aim and objectives: Our objective was to study the effect of pacemaker algorithms on atrial fibrillation progression. Subjects and Methods: Patients with dual chamber (group A) and single chamber (group B)pacemakers were included in the study. Patients with history of AF at the time of pacemaker implantation were not included in the study. The relation between pacemaker parameters and AF development was monitored. Result: Group A showed that RV pacing percentage had high significance for developing AF with P value P
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The role of the system of insulin-like growth factors in blood in soft tissue sarcomas
Статья
Although soft tissue sarcomas (STS) belong to a group of rare diseases of mesenchymal origin, their characteristic tendency to recurrence and high mortality necessitates the search for some prognostic bio-markers to identify patients at risk of their recurrence [1]. In this regard, the system of insulinlike growth factors (IGF) and their binding proteins (IGFBP) is of interest, since it has been established that dysregulation of the IGF system leads to the proliferation of cancer cells, migration and resistance to chemotherapy.
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Статья научная
At present, control of properties of biological membranes as targets of magnetic field applications within a living cell is the subject of considerable discussion in the scientific community. Experimental studies carried out by us demonstrate that ULF MF has an access to the most important mechanisms of tumor growth. The most likely mechanism among them is that responsible for the processes of free-radicals oxidation. Therefore, our research work was aimed at studies of influences of ULF MF on indicators of the anti-oxidation system in blood plasma and blood cells in rats in the chemically induced cancerogenesis. Our experimental studies were performed in 45 outbred albino male rats having a body mass from 160 to 180 g. The state of the anti-peroxidation protection of cell membranes was assessed by indicators of the fermentation subsystem of AOS (catalase, TPA, SOD), and the state of the non-fermentive subsystem of AOS was estimated by indicators of the concentrations of vitamins A and E in blood serum...
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Статья научная
Aims The aim of our research work was to investigate the state of the lipid peroxidation system - the antioxidant protection system (LPO-AOS) in heart tissue in rats received either Doxorubicin alone or in combination with Preductal premedication. Materials and methods Our experimental studies were carried out in mature male albino rats from outbread stocks (the cohort covered 50 animals) with an individual body mass from 150 to 160 g. The cohort included the following groups of the rats: the reference group covered 10 intact animals; group 1 (20 rats) received dosage of Doxorubicin of 2mg/kg, five times, up to a cumulative dose of 10 mg/kg; group 2 (20 animals) medicated as follows: the 5-day introduction of Preductal with dosage of 35 mg/kg followed by Doxorubicin medication according to the same schedule used in group 1. MDA, levels of the A & E vitamins, SOD and catalase activity, Total Peroxidase Activity (TPA), the ratios E/A, SOD/TPA and SOD/catalase were assessed in heart tissue...
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Статья научная
Aims The aim hereof is to study the activity of cathepsin D (CatD), alkaline phosphatase (ALP) and acid phosphatase (AP), the antitryptic activity (ATA) of acid-stable inhibitors (ASI) in rats in heart tissue and its draining lymphocytes under introduction of Doxorubicin and protection with Trimetazidine.
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Статья научная
We conducted a study of the state of intracardiac hemodynamics in elderly patients with hypertension in the Kabardino-Balkarian Republic, taking into account age, gender and geographic climatic differences.
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The state of the cardiovascular system in female students after use of different doses of caffeine
Статья научная
Our article is devoted to the study of the state of the cardiovascular system in female students after the use of different doses of caffeine. Drinking 200 mg of coffee leads to a significant increase in heart rhythm and diastolic blood pressure in girls. The maximum values of heart rate (HR) and blood pressure are reached 1 hour after caffeine intake. Thus, in this case, reported is an increase in the heart rhythm by 12.7% (P ˂ 0.05), a rise in the high blood pressure by 8.8% and that in the low blood pressure level by 12.0% (P ˂ 0.05), as compared to the respective initial values thereof. After drinking 100 mg of coffee, there are no significant changes in the indicators of the cardiovascular system performance recorded: an increase in the heart rate after 1 hour has been reported to be 9.5%, a rise in the systolic blood pressure (BPs) has reached 5.0% and that in the diastolic one (BPd) 6.4%, as compared with the values of the reference group. The use of different doses of caffeine does not lead to significant changes in the duration of the waves and segments on the electrocardiogram. 3 and 6 hours after drinking coffee, the indicators of the cardiovascular system are gradually decreasing, approaching their respective initial values.
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The state of the cardiovascular system in women during pregnancy
Статья научная
The work is devoted to the study of the impact of pregnancy on the state of the cardiovascular system in women. The process of pregnancy is accompanied by significant changes in the rhythm of the heart performance and blood pressure, and the duration of the ECG waves and segments are not significantly fluctuated. The heart rhythm, gradually increasing, reaches its maximum value of 87.3 beats per minute (P
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The study of hemodynamics in critical patients under intensive care unit conditions
Отчет
Studies of hemodynamics in critical patients under intensive care unit conditions have been a very difficult task until now [1]. There are a number of reasons for that. No instruments capable of noninvasively recording data on hemodynamics and metabolism, as well as the cardiovascular system performance, could be used. Of course it is reasonable that, according to the relevant methodology, all the data should be recorded on the 'here-and-now' basis, in real time, to enable rapid decision-making in order to save the patient's life.
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Статья научная
Celiac disease is an autoimmune disorder triggered by the ingestion of gluten in genetically susceptible individuals. The current study aimed to compare the levels of these antibodies in celiac disease patients on active gluten-containing diets and those on gluten-free diets to demonstrate the ability to get rid of Celiac Disease by Gluten-Free Diet. The study involved 100 participants, divided into 60 CD patients and 40 controls, where all participant match in age and gender. The patient group was further divided into two subgroups 40 active celiac and 20 GFD. Blood samples were obtained from all participants, and levels of anti-tTG and anti-gliadin antibodies were using Enzyme-Linked Immunosorbent Assay (ELISA) technology. The results showed The F test indicated a significant difference in the levels of anti-tTG and anti-gliadin antibodies between the active group (G1) and the diet group (G2) in comparison to the control group (G3), with a p-value less than 0.001. Upon conducting a deeper analysis using the least significant difference (LSD) on on anti-tTG IgA and IgG indicate that there are no significant differences between the patient groups G1 and G2, as evidenced by p-values of 0.120 for IgA. However, a significant difference was observed between G1 and G2 for IgG, with a p-value of 0.018. When comparing G1 with G3, and G2 with G3, significant differences were observed, with p-values less than 0.001. In the case of anti-gliadin IgA and IgG, the LSD test revealed a highly significant difference between G1 and G2, as indicated by a p-value less than 0.001. However, no significant differences were found between G1 and G3, with p-values of 0.499 for IgA and 0.110 for IgG. A highly significant difference was none the less observed between G2 and G3, with a p-value less than 0.001.In conclusion, This study highlights the importance of dietary adherence in celiac disease management. Patients on gluten-free diets had significantly lower levels of anti-TG and anti-gliadin antibodies, indicating better control of the autoimmune response. Monitoring these antibody levels can be a valuable tool in assessing the effectiveness of dietary interventions in celiac disease patients.
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Статья научная
The article presents some results of an interdisciplinary study aimed at clarifying the conditions for the use of cardiometric and electrodermal indicators of human activity as a means of attesting to visual online content. To record personal reactions to selected visual objects, the authors use a range of tools, including computer cardiometers, portable eye trackers and polygraphs of various modifications. To achieve this goal, the authors conducted a multi-level test of Russian youth using current political symbols and images from online communities and other social media platforms. The results of the study prove the high efficiency of using cardio-oculometric detection combined with automatic recording of electrodermal activity to obtain reliable information about affective and rational-logical features of perception of visual online content. The study also extends the research understanding of the specifics of using this combination of diagnostic tools in different conditions.
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The use of cardiometry in development of self-control skills by means of game sand modeling
Статья научная
The article presents experimental evidence of the validity of our hypothesis that progress in the formation and development of self-control can be fixed by assessing heart rate variability using the calculation of the Baevsky stress index (SI). Confirmation has also been obtained that this sort of cardiometric indicators can be applied as an essential element of effective bio-feedback in the course of improving a person’s ability to control his/her own psycho-emotional state using game sand modeling techniques. It is shown that the use of cardiometry in the development of self-control skills by means of game sand modeling contributes to the systematic phased internalization of the orientation scheme by the person, which he/she needs to control his/her own psycho-emotional state. The data obtained also demonstrate that the cardiometric measurements used in the course of such training help increase the rationality and awareness of the self-regulation skills to be formed and developed, and aid in strengthening the mindset for their constructive use in everyday life.
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Статья научная
The article presents experimental data confirming an assump-tion that an independent performance referring to the selection and ranking of visual stimuli by respondents allows not only to identify, but also to build a hierarchy of regulators of social be-havior of each individual. It is shown that this kind of diagnos-tics also makes possible to determine the prevailing moral and ethical regulators in behavior in a particular social group, which can easily be represented as the poles of semantic differentials. It is noted that an important feature of this type of diagnostics is the subject-genetic nature of the procedures performed, owing to which each respondent begins to more clearly realize his/her life priorities and expands his/her readiness for vitally important decision-making.
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Theoretical principles of cardiometry
Статья научная
Aims The article aims at describing the theoretical principles of cardiometry as a fundamentally new scientific field which enables the accurate measurement of the cardiovascular system parameters. Materials and Cardiometry is based on the mathematical model of hemodynamic methods processes. The model is described by G. Poyedintsev and O. Voronova equations. The variable values in these equations are the cardiac cycle phase durations recorded on the ECG. An original ECG lead of the ascending aorta reflects all the processes of the heart performance. Thus, it is possible to calculate the phase blood volumes. This method is an accurate indirect measurement method. The synchronous recording of the ascending aorta ECG and Rheogram enables monitoring of the compensation mechanism responsible for the normal hemodynamic performance. Results An innovative mathematical model of hemodynamics providing the creation of an innovative indirect method for measurement of the cardiovascular system parameters was developed. Conclusion The innovative method of cardiovascular system diagnostics enables to measure 7 main hemodynamic parameters using noninvasive technology for qualitative evaluation of 12 functions of cardiovascular system performance and general assessment of coronary flow status.
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Ред. заметка
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Theory of health: successful translation into the real life. General biological prerequisites
Отчет
The paper reveals logical relationships between events, facts and results of research studies and exemplary materials of practical applications of the adaptational reactions. It is demonstrated that the stress reaction by H. Selye and the anti-stressor type adaptational reactions by Lyubov Kh. Garkavi, Elena B. Kvakina and Maria A. Ukolova have become the cornerstone in development of scientifically grounded approaches to control of the organism states.
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Three-dimensional in vitro models for studying the chemosensitivity of breast cancer cells
Статья
Scientists agree that three-dimensional tumor cell cultures reflect the in vitro biological features of malignant tumors to a greater extent than it is the case with the conventional monolayer cultures. In particular, the results of assessing the effectiveness of anticancer drugs obtained in three-dimensional cell models are considered as more accurate and consistent with the tumor response in vivo, where sensitivity is usually lower than that found in the in vitro experiments. Some of the most developed cellular models are structures obtained using three-dimensional bioprinting, which include not only malignant cells, but also biogels to imitate the chemical and mechanical properties of the extracellular matrix of the tumor.
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