Статьи журнала - Cardiometry
Все статьи: 571
Статья научная
Today, among the urgent tasks facing the pharmaceutical science of the Republic of Uzbekistan is the study of introduced medicinal plants. Of the promising plants Erva woolly - Aerva lanata Juss of the amaranth family (Amaranthaceae) deserves special attention. A perennial or biennial herbaceous plant grows in many countries of Africa, Saudi Arabia, India, Indonesia, etc. For the first time, Aerva lanata Juss. was introduced on the territory of the former USSR by the Transcaucasian zonal experimental station VILR (Kobuletti) in the mid-70s, then in Ukraine, Uzbekistan and Kazakhstan. Aerva lanata is a dioecious plant. The flowers of A. lanata are nectariferous. Pollination of Erva woolly occurs under the influence of gravity inside the flower, wind, insects and rainwater. Erva woolly with more than one pollination and seed dispersal mode is able to invade a variety of habitats with different environmental conditions and grow as widespread weeds. Among other Aerva species, A. lanata cultivar has a wide range of pharmacological activities such as sedative, antiulcer, antiasthma, antidiarrheal, antioxidant, antihyperglycemic, antimalarial, hypolipidemic and other activities. It is used as a diuretic, for acute kidney damage, as well as for ulcerative wounds, rheumatism. Given the availability of the raw material base necessary to meet the possible growth in consumer demand and its widespread use in traditional and scientific medicine to create effective, low-toxic drugs intended for the prevention and treatment of diseases of the urinary system, Aerva lanata Juss L. was chosen as the object of research. An important stage in the standardization of the final product is the quality control of the technological process and the raw materials entering the production to obtain the finished product. Particular attention is paid to the method of quantitative determination of one of the active substances or groups of biologically active substances that affect the therapeutic effect of finished pharmaceutical products. It is known that the quantitative determination of the active substance is carried out by its extraction from plant materials. In this regard, the problem arises - finding the optimal conditions for the process of extracting the active substance. In view of this, it becomes necessary to conduct research to determine the optimal conditions for the extraction process. The objective of the research: the use of the mathematical planning method of the experiment for the complete extraction of flavonoids from the herb Aerva lanata. To achieve this objective, the following tasks were defined: - selection of the mathematical planning method of the experiment; - selection of method for quantitative determination of flavonoids amount; - statistical analysis of the obtained results. Optimization of the process of extracting the amount of flavonoids from the herb of Aerva lanata, which is predominant in its raw materials, was carried out using the method of mathematical planning of experiments by Box and Wilson. The optimization problem was reduced to determining the values of technological parameters that ensure the maximum yield of total flavonoids from the plant. As an optimization parameter, Y was taken - the content of the sum of flavonoids in the extract, in % of its content in the raw material. Conclusion. This article presents the results of modeling and optimization of the process of obtaining the sum of flavonoids from the herb Aerva lanata Juss. L. A comprehensive quantitative assessment of the influence of three experimental factors (alcohol concentration, hydromodulus and extraction time) on the yield of the total flavonoids was carried out using the method of mathematical planning of the Box-Wilson experiment. The objective was achieved by building a mathematical model based on the first order regression equation: Y=1.20+0.185X1+0.091X2+0.111X3 The adequacy of this process is shown, a mathematical model and parametric identification of this model are presented. As a result of the statistical analysis of the obtained data, the following optimal conditions for the process of extracting the amount of flavonoids from the herb of Aerva lanata were revealed in the quantitative analysis of raw materials: alcohol concentration - 50%; hydromodule - 1:60; extraction time - 30 min. The maximum yield of the sum of flavonoids was 1.52% by weight of dry raw materials. The resulting mathematical model of the extraction process will allow further optimization of the extraction of compounds of natural origin, taking into account the quantitative influence of each factor.
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Статья научная
Aims The paper offers some results from our experimental studies to determine validity of a complex performance fingerprint: the Baevsky stress index used to assess effectiveness of training programs: training sessions targeted at formation of phsychosomatic self-regulation skills and visual & verbal practical training course aimed at development of emotional intelligence. Materials and methods In order to determine the criterion-related validity of cardiometric assessments of training results, we have organized training sessions addressing scheduled staged formation of the self-regulation skills. Before the training sessions and after them, our training participants have been instructed to perform a set of three tasks, covering the following: - to imagine a calming video clip; - to imagine some TV news reporting various dramatic incidents, emergencies, calamities etc. - to generate self-relaxation, to perform the task to get relaxed and initiated or induced an emotional balance...
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Статья
The effectiveness of chemoradiation therapy (CRT) is conventionally assessed in terms of achieving clinical complete response (CCR), overall and event-free survival. Anal cancer (AR) is considered as one of the cancer diseases with a proven etiological agent: the human papillomavirus (HPV). The search for biomarkers to predict the effectiveness of CRT is always relevant, and an assessment of virological response (VR) may be useful for this purpose.
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Статья научная
Aims The article aims at describing the basic principles of cardiometry - a fundamentally new scientific field which enables the accurate measurement of cardiovascular system parameters. Materials and Cardiometry is based on the mathematical model of hemodynamic methods processes. The model is described by G. Poyedintsev and O. Voronova equations. The variable values in these equations are the cardiac cycle phase durations recorded on the ECG. Results An innovative mathematical model of hemodynamics providing the creation of an innovative indirect method of cardiovascular system parameters measurement was developed. The ECG processing is performed by means of the wavelet transform for detecting the boundaries of the cardiac cycle phases. Conclusion The innovative method of cardiovascular system diagnostics enables to measure 7 main hemodynamic parameters using noninvasive technology for qualitative evaluation of 12 functions of cardiovascular system performance and general assessment of coronary flow status. One of the problems the model of hemodynamics deals with is identifying the boundaries of the cardiac cycle phases. To identify the boundaries of the cardiac cycle phases the method of finding the extrema on the initial ECG and the differentiated ECG basing on the wavelet transform was used.
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Why transradial instead of transfemoral approach for the percutaneous coronary intervention
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Work life balance of medical professionals during Covid-19
Статья научная
Work life balance even though has been a contemporary topic in recent years but still there are organisations and job profiles which do not allow a good work life balance. Most researchers focused on female doctors or female nurses for their research but researchers have proved that work life balance impact equally irrespective of gender. During pandemic we are hearing a greater number of cases where medical professionals are working in difficult conditions. Even during pandemic work life balance should be given importance. Questionnaire was circulated through social media and 80 responses were received. Finding of this study reveals that medical professionals’ work life balance is greatly affected by organisational factors as well as emotional and physical wellbeing. This research will have social implications in terms of understanding challenges faced by medical professionals in terms of managing their work- life–balance
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Workplace motivation and job satisfaction among generation Y in India
Статья научная
Employee work motivation and job satisfaction are dynamic and demanding goals for a business. It has been much more daunting in today’s dynamic workforce. A business is a wonderful workspace that serves the expectations of each employee and motivates each one to achieve its objectives. The present research illustrates the desires and aspirations of various employees regarding work encouragement and satisfaction from the organization. The focus is on understanding specific characteristics, needs, and expectations of Generation Y, which in today’s context are considered to be critical. There is also an emphasis on learning how and what motivates workers in Generation Y. In addition, racial and geographic diversity is often taken into consideration in this report. The company that recognizes the requirements and can help its workers improve is producing greater performance. In this analysis, a technique of the interview is used. A group of 254 workers from different backgrounds and ages is evaluated for the quantitative model. Any variables suggesting relevant HR behaviors are taken from earlier research in this report. In the study of human personal variations in organizational efficiency, the “locus of influence” aspect is often taken.
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Статья научная
Breast cancer (BC) takes a leading position among all malignant neoplasms in women. One of the critical aspects of the radical treatment of BC is the development of post-castration syndrome (PCS) in patients of reproductive age, who as a rule reach physiological, social and professional maturity, competence and status in the period up to 45 years of age. Traditionally used hormone replacement therapy, despite its high efficiency, has a number of contraindications and side effects. Therefore, it is urgent to develop and implement in clinical practice the effective methods of rehabilitation of patients with PCS. One of the main areas of research is the study of the prospects for the use of therapeutic xenon-oxygen mixtures in restorative medicine, as it has a pronounced anti-stress, hormone-modulating, antidepressant and sedative effect. Accordingly, the aim of the present paper is to study the effect of xenon on cardiovascular system markers, brain bioelectric activity and psycho-emotional state in oncology patients with hormone-positive breast cancer in the stage of surgical castration...
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Introduction. Radical surgical treatment of cervical cancer (CC) involves the removal of the uterus with suspected metastatic foci in the regional lymphatic collectors and the ovaries. In this case, total ovarian suppression in patients of reproductive age is accompanied by polysystemic functional disorders in the form of postovariectomy syndrome (POES), which is manifested by changes in homeostasis, neuroendocrine and cardiovascular insufficiency, pronounced disorders in the psychoemotional sphere with the formation of a persistent stress situation and the development of psychological dysfunction [1]. Most of the methods of rehabilitation therapy are limited in their use and do not always lead to a satisfactory result that promotes searching for new technologies in the rehabilitation of cancer patients at all stages of antitumor treatment. In order to achieve a balanced response by the organism of a cancer patient to stressful events.
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Статья научная
Background: Hair color repigmentation in the recipient area is a newly detected phenomena after hair transplantation. It’s detected especially in patients with gray or white hairs in the donor area, in which transferring these follicles to the recipient area stimulate them to regain their original blackish color, this may occur due to various stimulants that release during wound healing of slits after hair transplantation that trigger melanin production within the melanocyte inside the hair roots and promote hair repigmentation in the recipient area.
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