Статьи журнала - Cardiometry
Все статьи: 571
Статья
Topicality. The altered glucose metabolism in cancer cells, known as the Warburg effect, is a new area of research of anticancer agents [1]. To date, many compounds have been identified that address the glucose metabolism. However, many of them failed at the early stages of clinical trials, demonstrating systemic toxicity [2, 3]. The glycolysis inhibitor iodoacetate (IA) has a good antitumor effect, but, like other glycolysis inhibitors, it has an unsafe profile. Liposomes (LS) are a good element to provide the required targeted delivery and reduce the systemic toxicity of drugs. The aim of our study was to identify the effect of iodoacetate encapsulation in liposomes made on its antitumor properties and assess the systemic toxicity thereof. Methods. LS were prepared by extrusion. The dose of IA encapsulated in drugs was quantified using high performance liquid chromatography. The toxic effect was assessed by biochemical blood markers. The antitumor and antimetastatic activity was studied in a Lewis carcinoma model using short-term (4 days) and two-week long-term regimens.
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Study of the effect made by interval hypoxic training on cardiac metabolism and hemodynamics
Статья
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Статья научная
This research aims to find out the status of trust the people of the world’s two prominent democracies - The United States of America, known worldwide as the most powerful democracy, and the Republic of India, known as the World’s Largest Democracy in the handling of the COVID-19 epidemic, that has gripped the entire world by storm. Also, the second objective of this study is to find out if the population of the two nations believe that their governments have actively used disinformation tactics - once thought to be used only by a despot or autocratic governments, on its populace to control the COVID-19 panic and hysteria surrounding it. This study also aims to understand the relationship between trust and disinformation, if any. The study aims to fulfill its objective via individual responses. The survey was conducted via Google Forms and was floated via social media apps like Face book, Linked In, Whatsapp, Instagram, and popular chat sites such as Omegle and Reddit.
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Статья научная
Due to the improper use of antimicrobial drugs, rates of morbidity and mortality from antimicrobial resistance have been rising globally. Consequently, increasing our knowledge of and data on antimicrobial resistance in clinical settings makes it feasible to treat patients with more selective antimicrobial medications and lower the likelihood of resistance. Of the 100 isolates, 45 were female and 55 were male. Only 46 isolates have ability to growth on mannitol agar and only 21 isolates detect as S. aureus by Vitek-2, the study revealed that approximately S. aureus and S. pseudintermedius and S. sciuri with probability of 45.6 % and 34.7%, 19% respectively. For every S. aureus isolate, an antimicrobial susceptibility test against eleven antibiotics was conducted. should look into the pattern of multidrug resistance and the best course of treatment for this kind of bacteria. The susceptibility test was conducted using the antibiotic disc diffusion method, all isolate resistance to penicillin (100%), all S. aureus isolated was resistant to Tetracycline, Amikacin, Tobramycin, Gentamicin, Doxycycline, and Chloramphenicol with percentages of 95%, 88%, 75%, 64%, 75%, and 100%, respectively. The result showed the sensitive rate of S. aureus to Trimethoprim\Sulphamethoxazole and Trimethoprim and Rifampicin, Norfloxacin was 85%, 74%, 95%, 90%, it the most effective drugs used in the present study and which showed the lowest rates of resistance. The aim of this study is to study the resistance pattern of s. aureus bacteria isolated from patients suffering from skin diseases, including diabetic foot, burns, and others, collected from hospitals in the city of Najaf.
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Succinate as a mobilization cue
Статья обзорная
Succinic acid, being a metabolite of the Krebs cycle and the end product of anaerobic transformations in mitochondria, functions outside mitochondria and cells as a regulatory signal. In the cytosol, micromolar amounts of succinate stabilize the transcriptional hypoxia-inducible factor HIF, which triggers the genes responsible for adaptation to hypoxia. Outside the cells, succinate activates the SUCNR1 receptor, which increases the concentration of intracellular calcium. The effect of short bursts of endogenous succinate accumulation and signaling after hypoxia/ischemia, or extreme glucose use from physical exercise should be distinguished from the effect of a permanently increased level of endogenous succinate under pathology (obesity, diabetes mellitus, chronic ischemia, succinate dehydrogenase damage). A short succinate signal triggers an adaptive response by an organism. Prolonged rise and highly elevated levels of endogenous succinate is a pro-inflammatory, damaging factor that can contribute to the progression of neoplasms. Use of succinate-containing compositions at a dose of 0.5-5 millimole can only provide a short signal. This is due to the positive effect of a number of succinate-containing agents.
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Отчет
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Статья научная
By combining hydrothermal technology and deposition, it is possible to synthesize ZnO/Ag2O nanocomposites simply and effectively. The structures, compositions and morphologies of ZnO/Ag2O composites were characterized by XRD, EDS, SEM and TEM. The photocatalytic performance of the photocatalyst for degrading methylene blue (MB) has been evaluated under visible light. Specifically, The results showed that the most photocatalytic activity of MB in ZnO/Ag2O nanocomposites is two times higher than pure ZnO. Under irradiation with light. The increase in photocatalytic activity is due to the formation of heterostructures between Ag2O and ZnO, strong visible light absorption and better separation efficiency of photo-induced e––h+ pairs. In addition, the nanocomposite ZnO/Ag2O appeared to be completely stable against photodegradation under wight light. Finally, after washing dyes on the surface with high efficiency, the photooxidation process was repeated four times in the same ZnO/Ag2O nanocomposite.
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Systematic design of optimized pulse shape for transthoracic defibrillation
Статья научная
In the study conducted by us previously, it was found that not only the energy of the discharge, but also the amplitude of current, the pulse duration and its shape have their significant influence on the efficacy of defibrillation. Until now, no systematic approach to the comparison of the pulse shapes effectiveness has been available. An identification of the optimal pulse parameters for defibrillation has not only theoretical aspects but also engineering details in the design implementation. In order to conduct a complete pulse optimization, required is a multidisciplinary approach to determining boundary values and searching for further ways to improve the efficiency of electropulse therapy. An understanding of the relationship between the biphasic pulse parameters and the criteria for healthcare quality can make it possible to increase the survival rate of patients with ventricular fibrillation and ventricular tachycardia. The implementation of the current stabilization system in the defibrillator allows realizing an individual selection of the pulse energy defibrillation.
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Статья
It is known about numerous regulatory disorders in the body during the development of a malignant process. However, in this case, the natural mechanisms of the anti-tumor resistance remain poorly understood. The concepts on the systemic processes during the development of general nonspecific adaptational reactions of the body (AR): stress and anti-stress ARs, discovered by G. Selye and Russian scientists L.Kh. Garkavi, E.B. Kvakina and M.A. Ukolova, have contributed to the development of effective technologies for preventive and complementary therapy for the purposes of clinical oncology
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Testing Herzberg's two factor theory on millennials
Статья научная
This study tests Herzberg’s two-factor theory of motivation on working millennials. The purpose of the study is to evaluate what the assumptions and the findings of the original study hold for millennials. With the increasing trend of amalgamation of work life and personal life, job satisfaction and general job happiness have never been more on an individual’s personal life. This impact is far-reaching, with strong indications of affecting the employees’ physical, mental, and social health. In such a scenario, organizations need to keep their employees motivated and satisfied. For studying Herzberg’s two-factor theory of motivation on working millennials, we have selected respondents with work experience of at least one year. We have not restricted the study to any particular industry; hence our sample is across all industries. The type of sampling used was convenient sampling. From the analysis, we have found that for the concerned sample, hygiene factors tower above the motivating factors in terms of job satisfaction for millennials. From the data collection and analysis, we proved that both motivators and hygiene factors affect job satisfaction, unlike what has been said by Herzberg. This study will contribute to the exciting literature on motivation.
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Статья научная
The aim of the current study is to find the levels of MIP and IL-23 in the serum of a group of male patients infected with Toxoplasma gondii who were diagnosed with the disease by rapid IGg screening and to find the levels of IGg protein in the blood serum of a group of male patients infected with the disease. The aforementioned immune indicators in the serum of healthy people as a control group. Blood samples were taken from donors who came to the main blood bank in Najaf Al-Ashraf, and the relationship between these immune indicators was studied using ELISA technology. The total number of males was (78), (48) of whom were sick males and (30) healthy males who were not infected with the disease. The study showed that the percentage of infected males was 61% and those who were not infected were (4.38%). Age was studied and it was found that there was no significant difference in the age of patients and healthy people, and that the age range of patients was between (16 - 56) years. Serum tests were conducted for MIP, there was a slight increase, and a highly significant increase for IL-23. The current study demonstrated the existence of positive relationships between MIP-1 and IL-23.
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The article is devoted to a novel noninvasive measurement of parameters of metabolic processes in the cardiac muscle fiber cells upon an original ECG processing. Theoretically substantiated is an original method of the ECG cardiac cycle phase analysis, which allows measuring the concentration of oxygen, lactate and phosphocreatine in arbitrary units in the cardiac muscle fiber cells in each cardiac cycle. The results of practical applications of the above cardiometric method for assessing the conditioning in a high-performance swimming athlete are discussed herein. Recommendations for a widespread use of the method in practice are discussed herein, too.
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The G.Poyedintsev - O. Voronova mathematical model of hemodynamics
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Aims The objective is to demonstrate the features of an original mathematical model of hemodynamics, developed by Russian researchers G.Poyedintsev and O.Voronova. Materials and methods The proposed original mathematical model of hemodynamics is based on the laws of the fresh hydrodynamic theory of the "third" fluid flow mode. Results As a result of the application of the above mathematical model of hemodynamics, an advanced method for noninvasive measuring of a complete set of hemodynamic parameters with the use of the cardiac cycle phase durations, implemented by the Cardiocode device, have been elaborated. Conclusion The unique method for noninvasive measuring of a complete set of hemodynamic parameters, which has been developed on the basis of the above mathematical model of hemodynamics, is a promising source for considerable expanding of diagnostics capabilities.
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Другой
It has long been thought who wants to be healthy and strong should go in for sports: do exercises, run, swim, participate in sports games and so on. Speaking about amateur sporting participants, the result of being vigorous, energetic, able-bodied and physically & emotionally attractive is important for us.
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The course of very severe aortic stenosis due to bicuspid aortic valve calcinosis in a young man
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In the young patients with bicuspid aortic valve, manifestation of aortic stenosis (AS) often remains silent. Asymptomatic very severe AS makes medical decisions challenging. For the better evaluation of AS severity and estimation the indications for the surgical treatment any stress test is preferable. We report a case history of a 46 year old male patient with successfully treated critical AS with severe heart failure (HF) that demonstrates effectiveness of the surgical treatment. Successful aortic valve replacement (AVR) was beneficial and guided to increase functional class, improve LV systolic function, normalization of the heart chambers, decreased pulmonary hypertension (PH), determined reversible left ventricle (LV) hypertrophy. Summarizing our experience, we hypothesize that surgical treatment of this patient with asymptomatic very severe AS would be helpful in increasing quality of life and avoiding manifestation of AS with critical severe HF.
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The effect made by the vaginal microbiome on pregnancy outcome
Статья научная
This article considers the effect made by the vaginal microbiome on the outcome of pregnancy. The vaginal microbiome is important for the health of a woman’s reproductive system and can affect some critical aspects of pregnancy such as the development of preeclampsia and the likelihood of premature birth. This study is based on an analysis of the composition of the microbiome in pregnant women and the correlation of the data obtained with the outcomes of their pregnancy. The results of the study can help in the development of new approaches to predictive diagnostics and treatment of possible pregnancy complications caused by changes in the vaginal microbiome.
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Статья научная
The aim is to study the effect of comorbid pathology, namely, diabetes mellitus, on free radical oxidation in the mitochondria in the heart cells in female rats with experimental Guerin carcinoma.
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Статья научная
The aim of present study was to compare the effect of Ca chelat-ing anticoagulants (EDTA, citrate and oxalate) and antithrombin anticoagulant (heparin) on some rabbits plasma biochemical pa-rameters at room temperature 25 °С and extreme temperatures -18 °С and 50 °С for 1hr. Five male rabbits weighting between 800-1000gm, kept in the animal house /College of Veterinary Medicine/University of Diyala, under 12:12 dark light cycle with ad libtum food and water in individual cages (60cm,40cm) during November and December /2022. Four ml of blood samples were collected by cardiac puncture (23 G needle) into four tubes con-tain anticoagulants: (EDTA, citrate, oxalate and heparin)one ml of blood for each tube; then the blood samples were kept at :room temperature 25 °С, waterbath 50 °С and refrigerator -18 °С, for 1hr then put in centrifuge at 3000 rpm for 15 min. From total ex-amined blood samples =24 for each Ca chelating anticoagulants (EDTA, citrate and oxalate) and antithrombin anticoagulant (hep-arin) after 1hr under in 25 °С, -18 °С and 50 °С. The both groups of anticoagulants (Ca chelating and antithrombin) showed no significant differences P>0.05 between them in level of biochem-ical parameters (glucose, total protein, cholesterol and urea) after 1 hr at 25 °С; on the other hand significant increase in plasma glucose, total protein and cholesterol beside significant decrease in plasma urea of Ca chelating anticoagulants after 1hr at -18 °С and 50 °С as compare with antithrombin anticoagulant. In con-clusion; heparin was more effective than Ca chelating anticoag-ulant in preserve plasma biochemical parameters within normal values under extreme cool and hot condition
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Статья научная
The aim of present study was to compare the effect of Ca chelating anticoagulants (EDTA, citrate and oxalate) and antithrombin anticoagulant (heparin) on some rabbits plasma biochemical parameters at room temperature 25°С and extreme temperatures -18°С and 50°С for 1hr. Five male rabbits weighting between 800-1000gm, kept in the animal house /College of Veterinary Medicine/University of Diyala, under 12:12 dark light cycle with ad libtum food and water in individual cages (60cm,40cm) during November and December /2022. Four ml of blood samples were collected by cardiac puncture (23G needle) into four tubes contain anticoagulants: (EDTA, citrate, oxalate and heparin)one ml of blood for each tube; then the blood samples were kept at :room temperature 25°С, waterbath 50°С and refrigerator -18°С, for 1hr then put in centrifuge at 3000rpm for 15min. From total examined blood samples =24 for each Ca chelating anticoagulants (EDTA, citrate and oxalate) and antithrombin anticoagulant (heparin) after 1hr under in 25c°С, -18°С and 50°С. The both groups of anticoagulants (Ca chelating and antithrombin) showed no significant differences P>0.05 between them in level of biochemical parameters (glucose, total protein, cholesterol and urea) after 1 hr at 25C; on the other hand significant increase in plasma glucose, total protein and cholesterol beside significant decrease in plasma urea of Ca chelating anticoagulants after 1hr at -18C and 50C as compare with antithrombin anticoagulant. In conclusion; heparin was more effective than Ca chelating anticoagulant in preserve plasma biochemical parameters within normal values under extreme cool and hot condition
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Статья
Over the past decade, the use of adoptive immunotherapy has emerged as a promising approach to treatment of various malignancies, including breast cancer. Cytokines are involved in the development, differentiation and homeostasis of the T cells. Despite the similarities in signaling pathways, the γc cytokines shape the T cell responses differently: IL-2 plays a major role in the development and maintenance of the regulatory T cells, while IL- 15 stimulates the proliferation and cytotoxic functions of the CD8+ T cells and NK- cells that leads to an enhanced antitumor response. It is of interest to study the combined effect of these cytokines in an experiment.
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