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Статьи журнала - Бюллетень науки и практики
Все статьи: 5660
CAR T-клеточная терапия как современный метод лечения онкологических заболеваний
Статья обзорная
Ежегодный рост случаев онкологических заболеваний диктует необходимость поиска и разработки новых методов диагностики и терапии онкозаболеваний. В статье представлены результаты анализа современных литературных источников, посвященных CAR T-клеточной терапии, ставшей прорывным направлением в лечении ряда гематологических опухолей. В основе CAR T-клеточной терапии лежит создание пула опухоль-специфичных цитотоксических лимфоцитов путем внесения ex vivo трансгена, кодирующего химерный антигенный рецептор. В статье изложены основные принципы, возможные осложнения, преимущества и недостатки CAR T-клеточной терапии.
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CRM-системы как инструмент повышения эффективности бизнеса
Статья научная
В настоящее время для результативного ведения бизнеса, повышения конкурентоспособности компании, необходимо постоянно повышать эффективность управленческой деятельности, отслеживать и анализировать все бизнес-процессы. Применение специализированного программного обеспечения CRM позволит компаниям повысить эффективность управления взаимоотношениями с клиентами, а также оперативно решать текущие задачи.
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Calculation method of fastening the upper slope of the land bund for erosion and strength
Статья научная
To protect the slopes of the ground dam from the devastating effects of wind waves, ice, water flow, precipitation and other factors, a number of engineering measures are provided. Based on this, an engineering decision is taken on the choice of materials for fastening structures, as well as methods for calculating their stability. When calculating the stability of the upper slope, two cases of a combination of loads and impacts are mainly considered. One of them is the reduction of the water level in the reservoir with maximum speed, and the other is the case when the water level in the reservoir is at the lowest operational level. The article investigates the processes of sliding of natural slopes of the upstream dam. Taking into account the combined action of the forces of filtering, weighing and vapor pressure, as well as the force of hydrostatic pressure to the level of dead volume. The equation for the stability coefficient of a circular-cylindrical slip of a uniform natural slope of the upstream dam has been obtained.
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Catalytic properties study of mixed MFI-mord type zeolite in bioethanol transformation
Статья научная
The decrease in stocks of traditional fossil fuels contributes to the widespread growth of interest in renewable sources of raw materials and energy. Bioethanol can become a serious alternative to traditional types of fossil raw materials and fuels due to the possibility of its widespread production from agricultural waste and wood processing. Bioethanol can be used directly as a fuel, or after transformation into hydrocarbons. The transformation of bioethanol into hydrocarbons is carried out using zeolites and zeotypes of various types, while the main problem encountered for these systems is deactivation during the catalytic transformation. In this case, one of the possible solutions to this problem is the regulation of the acidic and diffusion properties of the catalytic surface of zeolites. Changing the acidic properties can contribute to a significant increase in the stability and activity of zeolites. In this case, the variation of acidic properties is possible by combining different types of zeolites. The article presents the results of a study of a mixed zeolite of the MFI type and mordenite in the reaction of the transformation of ethanol into hydrocarbons. Zeolite synthesis was carried out by a sequential method using zeolite seed grains for the synthesis of MFI structures and n-butylamine for the synthesis of a mordenite layer. The synthesized sample was tested on a flow-type setup with a tubular reactor. The effect of temperature, specific ethanol feed rate, and total pressure in the system was investigated. An increase in the reaction temperature from 350℃ to 370℃ contributed to an increase in the rate of accumulation of liquid hydrocarbons from 0.52 to 0.64 g(HC)/(g(Cat)*h), while a further increase in temperature to 430℃ contributed to a decrease in the rate of formation of liquid hydrocarbons to 0.32 g(HC)/(g(Cat)*h). An increase in the specific feed rate of ethanol from 0.5 to 2 g(EtOH)/(g(Cat)*h) contributes to a decrease in the yield of liquid hydrocarbons. An increase in the total pressure in the system from 1 atm to 15 atm promotes an increase in the rate of accumulation of liquid hydrocarbons from 0.34 to 0.83 g(HC)/(g(Cat)*h).
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Статья научная
The article talks about the causes of infection of birds with colibacillosis and pasteurellosis in farm enterprises and private farms, about research work carried out in recent years at poultry farms, about the influence of opportunistic microbes on the activities of farms. The difference in infection of domestic chickens with colibacillosis and pasteurellosis for each age group was identified by us during the examinations. So, in 30-day-old chickens, infection with colibacillosis 24.4%, pasteurellosis 31.1%, in 45-day-old colibacillosis 33.3%, pasteurellosis 37.7%, in 60-day-old colibacillosis 20.0%, pasteurellosis 26.6% was detected.
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Cavitation generator development process at Russia and abroad
Статья научная
The energy situation in the world indication a rapid increase in the consumption of natural resources. The only way out of this situation is the development of alternative environmentally friendly technologies. The research and utilization of cavitation heat generators will help ease the energy crisis and reduce exhaust emissions from fuel combustion. Therefore, it is a potential research topic.
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Cerulein induced acute pancreatitis in experiment
Статья научная
Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, which ranges from mild, self-limiting disease to a severe form that is associated with multiple organ dysfunction syndrome (MODS), high morbidity, and mortality. Unpredictable nature of the disease, heterogeneity of disease presentations, and limited access to human samples, make research on human tissues impractical and often very difficult. We tried to identify crucial events in the pathophysiology of AP, in the course of several in vivo experimental models of the AP induction. In vivo experiment was carried out on rats using the analog of cholecystokinin octapeptide - Cerulein. The rats were divided into groups, in each group there was a different dosing regimen of the drug. As a result of a series of experimental studies, it was found that the interval low-dosage induction of AP causes more severe damage of pancreas tissue than a single administration of higher doses of the test substance.
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Change of gray-brown soils water-physical properties under the winter wheat
Статья научная
Research is conducted at the Terter Regional Experimental Station of the Research Institute for Agriculture. In order to improve soil fertility and obtain high and high-quality crop yields, we studied the water-physical properties of the soils of the experimental plot. Soil and fertilizer treatment in the 0-30 cm layer reduced the density of the soil but increased the natural moisture and total porosity compared with the control variant. As a result, soil fertility increased, which in turn significantly affected the grain yield of winter wheat.
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Статья научная
The article reflects the study of the influence of climatic and seasonal factors on the body of people of middle, elderly and senile age. These factors significantly aggravate the course of many diseases, worsen health and reduce the body's performance. The incidence of cardiovascular disease is often associated with risk factors and seasons. Most people aged 65 years and older often suffer from hypertension. With age, the number of such patients increases significantly. Severe hypertension is rare in humans because patients with hypertension do not live to an advanced age or often develop complications. Changing seasonal factors requires great attention to the functional state of the cardiovascular system. Patients with hypertension are very difficult to adapt to changing weather conditions, which worsens the quality of life of the elderly and leads to various complications. Changes in blood pressure in people of middle, elderly and senile age depending on the season of the year have been established.
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Characteristic properties of the spread of associative diseases in domestic chickens
Статья научная
In private poultry farms, located in the Fatmai and Sarai settlements of Apsheron district there have been carried out scatological and helminthological examination for various age groups. It became known that in Fatmai settlement infection of birds with various invasions, including with IE of ascaridiosis was 32.0%, II 2-31 of specimens, with IE of raillietinosis 18.9%, II 1-9 of specimens, with IE of heterakiosis was 30.9%, II 2-28 of specimens, and according to the results of examinations, conducted on poultry in Sarai settlement, with ascaridiosis having IE of 30.7%, II 1-29 of specimens, with IE of raillietinosis of 19.1%, II 2-17 of specimens, with IE of heterakiosis of 30.2%, II 1-23 of specimens of helminths, have been identified in the mixed form.
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Статья научная
By the order of the President of the Republic of Azerbaijan dated April 1, 2008, Goygol National Park was established in the administrative territories of Goygol, Dashkasan and Goranboy districts from 6739 hectares to 12755 hectares. The grassland vegetation of Goygol National Park and the lake ecosystem it surrounds is one of the floristically rich regions of the Caucasus. The richness and diversity of flora is related to the geomorphological complexity of the area. On the other hand, the reserve regime allows the protection of vegetation. Modern subalpine vegetation has changed dramatically as a result of mowing and grazing. Thus, short (13-15 cm) grass or grass-steppe plant groups have formed in the place of relatively tall plants that existed earlier in many pasture areas. The flora composition of subalpine meadows is much richer than the meadow associations of other mountain zones. 70-80 (100) flowering plants were recorded in many vegetation groups. The climate of the Alpine belt is distinguished by its harshness. Short summer (2.0-2.5 months), low air and soil temperature, abundance of atmospheric precipitation, etc. are characteristic features of the alpine zone.
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Characteristics of the Hole-Meadow Vegetation of Kur-Aras Lowland (Azerbaijan)
Статья научная
In article the description of the main types of meadow communities which were registered in Mil plain was given. It was also given their geobotanical classification. Distribution, contemporary situation, species biodiversity, morphobiological, bioecological and phytocenological features of this vegetation was analyzed. It was determined that hole-meadow vegetation type of researched area contains 4 formation classes, 14 formation groups and 39 associations.
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Characteristics of the genre and style in the works of Yassawi
Статья научная
In the form of hikmet Ahmed Yassawi is a historical document that reads the life of the Yassawi sheikh himself, divided by him into two periods: sixty-three years on earth and sixty-three years under the earth. The results of the study of the Hikmet Corps convince that Ahmed Yassavi, despite the presence of phantasms in his texts, lived and served his faith as a sane person who organized an authoritative Sufi organization in Turkestan and effectively led it for decades.
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Chemical composition and pharmacological activity of plants of the Hypericum L. genus
Статья обзорная
The purpose of this work was to present the results of summarizing the literature data on the chemical composition and pharmacological activity of the Hypericum L. genus. The chemical composition of St. John’s wort (Hyperici herba) has been studied quite fully within the Eurasian area of the species; more than 80 components have been identified. The main biologically active compounds of raw materials are anthracene derivatives (hypericin), flavonoids (rutin, quercetin, hyperozoid), phenylpropanoids (chlorogenic acid) and hyperforin. The review article presents physical constants and spectroscopic ((-NMR) proton magnetic resonance, (13C NMR) 13C nuclear magnetic resonance, (-UV) ultraviolet, (-IR) infrared) interpretations of biologically active substances obtained from secondary metabolites from species belonging to genus. The results of pharmacognostic and pharmacological studies determine the feasibility of clinical trials of St. John’s wort raw materials drugs and their use in a wide therapeutic range in the complex treatment of diseases. Herba St. John’s wort is a promising source of raw materials for obtaining antibacterial, antiviral, anti-inflammatory, astringent, diuretic, antidepressant, antioxidant, anticarcinogenic, immunotropic and adaptogenic agents.
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Chemical composition of the aerial part of Valeriana alliariifolia adams
Статья научная
The article presents information about the component composition of the acetone extract of the aerial part of Valeriana alliariifolia Adams. Plant raw materials for research were collected in the flowering phase from Batabat Reserve, Shahbuz district of Nakhchivan. Crystalline substances were obtained from the acetone extract of the plant. The individuality of the substances was checked by thin layer chromatography on Silufol UV 254 plates. The component content of the obtained extract was determined by the Gas Chromatography-Mass Spectrometry method (GC-MS). GC-MS analysis of the aerial part of the plant revealed the presence of five volatile constituents such us methylene chloride; trichloromethane; carbon tetrachloride; carbonic acid, ethyl-, methyl ester; ethane 2 chloro 1,1 detoxy.
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Choosing an effective podcasting service for learning English language
Краткое сообщение
The rapid development of network information technologies opens up new prospects in the field of education. It is safe to say that in the modern world there is a tendency to merge educational and information technologies in order to form on this basis fundamentally new integrated learning technologies, based, in particular, on Internet technologies. With the use of podcasts, learning becomes interactive, the importance of independent work of students increases, the intensity of the educational process is seriously increased, etc.
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Chorological analysis of species of Sedum L. genus distributed in the Lesser Caucasus
Краткое сообщение
The Sedum L. genus is represented by 22 species in the Azerbaijan flora. According to the system of N. N. Portenier, 14 species distributed in the Lesser Caucasus were chorologically analyzed and their geographical elements were determined.
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Chromatic “zero signs” in modern period cities
Статья научная
The research object is the chromatic “zero sign” understood as a meaning without a form, as an absence of positive significance, which should have been presented analogically with the other syntagmas, where a sign with the same meaning has an explicit form. The goal of the study is to undertake a theoretical reconstruction of ways and means through which “zero signs” manifested themselves in the urban space of the modern period. The paper discusses differences between “zero signs” and index signs, reveals the functions of “zero signs” in the European urban environment of the modern period. It contains the description of colour limitations and appeals for practically complete negation of colour (for usage of chromatic “zero signs”) presented in the documents regulating urban colouring of Germany, France, Italy, Russia and other countries of the 18th-19th centuries. Practical recommendations of how to choose colours, suggested by F. C. Schmidt in his book “People’s architect” are analysed. Content of ordinances of Paris authorities, the structure of the colour plan of Turin, related to colour decrees of the Russian Empire are discussed. The idea of imitation of the constructed urban spaces to the ancient ones is considered as a basis of colour negation in urban coloristics. It is shown that the concept of “zero sign” opens wide prospects for the analysis of sign systems outside a natural language, namely a system of urban colouring where cases of colour negation of city objects are rather frequent throughout the course of history of urban settlement development.
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Chromatic “zero signs” in the Soviet urban colour design
Статья научная
The research object is the tradition of сhromatic colours displacement from the urban environment. The main goal of the study is to analyse the role, that chromatic “zero signs” played in the environment of Soviet cities and towns, and to reveal their semantics. The findings and key principles of semiotics are used as the main theoretical and methodological research tool. Urban coloristics is seen as a language based on a system of interrelated oppositions, and the non-use of color in urban space is discussed in the context of the role of “zero signs” in sign systems outside the natural language. The author provides an analysis of the history of the development of urban colouristics and, on this basis, justifies the idea of importance for studying and understanding of “zero” colour as a semiotics object the “reflexive symmetry” principle and the usage of an ethnolinguistic strategic line of the analysis as well as a social and cultural one. The paper reveals the unique additional shades of meaning that the non-use of colour in urban coloristics acquired due to a special socio-cultural situation of the Soviet period. The social structure of Soviet urban society and its change under the influence of urbanization and rural migration are analyzed. We consider the value system of urban residents and analyze its relationship with the social division of urban space. The mechanisms supporting chromophobia in Soviet society are described. The specifics of Soviet urban spaces are discussed in comparison with the cities of the rest of Europe. Based on the analysis of architectural features of constructivism, neoclassicism, and Stalin empire style, different forms of “zero signs” in the space of Soviet cities and towns are identified and characterized.
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Cilioplankton communities as an indicator of the pollution degree in the Caspian Sea
Статья научная
During 2014-2021 years a study of the species diversity of planktonic ciliates of the Caspian coast of the Absheron Peninsula was conducted. As a result of research in planktonic communities of free-living ciliates, 62 species, belonging to 22 families were observed. Among the recorded families, Strombidiidae takes first place in terms of the number of species. The families Uronychiidae, Nassulidae, Epistylidae, and Zoothamniidae were represented by only one species. A correlation between similarity of the planktonic ciliates species diversity and the degree of organic pollution of coastal area marine water has been established. The results of the cluster analysis showed that the highest similarity of the species diversity (95.5%) was noted for two collection points on the northern coast of Absheron, near the settlements of Novkhani and Bilgah. This is due to the fact that the northern coast is less polluted by oil products and domestic sewage. Thus, according to the similarity of species diversity of planktonic communities of ciliates on the coast of the Absheron Peninsula, the two clusters are clearly distinguished. One unites the cleanest sites (Novkhani and Bilgah - 95.5%), and all the other 4 stationary points of the collection (Sumgait, Turkan, Shikh, Sangachal - more than 50%) are combined into the second cluster.
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