Статьи журнала - Cardiometry
Все статьи: 571
Статья научная
Aims: to study the content of regulatory peptides in the hypothalamus and pituitary gland, as well as sex steroids in the gonads in rats of both sexes with Guerin’s carcinoma against the background of hypothyroidism. Materials and methods. Our experiment was performed in white outbred rats of both sexes with induced hypothyroidism, against the background of which Guerin’s carcinoma was transplanted. In 1% homogenates of the pituitary and the hypothalamus and in 10% homogenates of the gonads in the animals from the main and reference groups, the levels of GnRH (Casabio, China) were determined by the ELISA method using standard kits, and the content of LH, FSH, estradiol (E2), testosterone (T) and progesterone (P4) by the RIA method (Immunotech, Czech Republic). Statistical analysis of the results was performed using the Statistica 10.0 software package. Results. In females of the main group, the level of GnRH in the hypothalamus increased by 1.6 times, but the content of LH and FSH in the pituitary gland decreased, while in males the content of GnRH decreased by 1.4 times and FSH by 1.6 times compared with the intact animals. In the gonads of females of the main group, the content of E2 and T decreased by 1.3 times, but the level of P4 increased by 4.7 times, while in males the T production decreased by 7.1 times. Hypothyroidism, against the background of which Guerin’s carcinoma developed, had a significant effect both on the central links of the HPG axis and the peripheral ones, producing an additional hormonal imbalance in sex steroids
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Статья научная
Aims The aim hereof is to study the cardiovascular system disorders in the early post-castration period in patients with locally advanced cervical cancer and a possibility of correction of such disorders with the low-dose xenon therapy
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Ред. заметка
The offered noninvasive device and technology CARDIOCODE (www.cardiocode.ru, www.cardiometry.net) are capable of delivering data on any changes in the performance of the cardiovascular system and tracing development of any processes that may occur in the heart and blood vessel system, and all that in a very simple and most accurate way.
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E-learning in formal education under forced conditions using SDT and tam
Статья научная
This study aims to understand the students’ attitude towards e-learning under the forced environment of the COVID-19 pandemic. This study gives a fresh insight into e-learning, considering the lack of comprehensive research on the influencing variables that impact the user acceptance of e-learning by learners in the Indian Universities during COVID-19 pandemic. The rational model has been constituted based on the Technological Acceptance Model (TAM) and Self-Determination Theory (SDT) to study the effective influence of Autonomy, Relatedness & Competency on the construct of TAM. The result showed significant relations of the self-determination variables with perceived ease of use & perceived usefulness, which further helps us establish a relationship between intrinsic & extrinsic factors of SDT framework with attitude and satisfaction level of Indian University students towards e-learning. This study will assist in bridging the gap between the understanding of organizations and actual factors impacting students’ learning process during the pandemic of COVID-19.
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ECG as a quest for extracting new data: non-invasive measurement of acid-alkaline parameters
Статья научная
Aims A cardiac muscle performance assessment in terms of acid-alkaline balance has never been carried out before. The studies show it is possible to evaluate indirectly aerobic, anaerobic and phosphocreatine processes in the cardiac muscle using ECG only. The aim is to study the capabilities of acid-alkaline balance measurement in the cardiac muscle using ECG only, in combination with the heart cycle phase analysis. Materials and methods The ECG of the ascending aorta is recorded with Cardiocode device. Amplitudes of the derivatives of leading and trailing edge of R, L and j waves are measured. The QRS complex amplitude depends on the amplitudes of the septum and myocardium muscles contractions. The septum is contracted because of the lesser resistance since the myocardium muscles are not loaded yet. When the myocardium muscles are contracted, they take a heavier load since the septum remains under static strain. It allows evaluating the difference in the energy consumption for each group of the muscles according to the respective ECG derivative...
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ECG periodic table: a new ECG classification based on heart cycle phase analysis
Статья научная
Aims The article considers the development of the periodic table of ECG phase changes which should reflect the variety of the ECG curves and can be used as reference system for diagnostics purposes. Materials and methods More than 5,000 ECG records were studied. They were recorded as original single-lead ECG of the ascending aorta. This fundamentally new ECG lead system reflects all processes in cardiovascular system. It was named by its developers the “ECG – HDA”. Basing on the theory of cardiac cycle phase analysis, the authors defined deviations from the normal ECG curve. Clinical tests were conducted and descriptions based on the laws of cardiometry were provided. Results A fundamentally new system of the ECG curve evaluation has been developed. Conclusion It is stated that all the variety of the actual ECG curves can be divided into 10 groups. Each group contains 4 levels of characteristic changes, starting from the norm up to and including critical deviations from the norm. The results are presented in the “ECG phase changes periodic table”. The table can be used for very precise diagnostics. The periodic table enables assessing the capabilities of the practical application of electrocardiography from a new point of view.
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Effecacy of antisense oligonucleotide HUSH-11 with thiophosphate in treatment of melanoma in mice
Статья
Melanoma is one of the highly aggressive cancer diseases. Melanoma accounts for about 2% of the total cancer incidence in Russia. In a large number of cases, melanoma shows its potential to metastasize and becomes a cause of death. Aims. Our research team focused on the design and development of an anti-melanoma drug based on antisense oligonucleotides (ASOs) with thiophosphate for the use both in the postsurgery treatment and the targeted therapy.
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Статья научная
The aim was to study changes in the functioning of the hypothalamic-pituitary-gonadal (HPG) axis in BALB/c Nude mice of both sexes with multiple primary malignant tumors (MPMTs). The BALB/c Nude mice (n=84) of both sexes were divided into groups as follows: intact males and females (n=14), a reference group of mice of both sexes with standard subcutaneous inoculation of B16/F10 melanoma (n=14); the main group of mice with the reproduction of the MPMT model (n=14); B16/ F10 melanoma and Lewis carcinoma were inoculated into mice sequentially subcutaneously on two sides: one on the left side and the other on the right side. After 15 days of the growth of the malignant tumors, GnRH, LH and FSH contents were determined by ELISA using standard kits in 1% of the homogenates of the hypothalamic and pituitary tissues, and estradiol content (E2) was determined in 10% homogenates of ovaries and testes, as well concentrations of testosterone (T) and progesterone (P4) were identified in blood serum with the standard RIA kits (Immunotech, Czech Republic). Results. In the hypothalamus in females of the reference and main groups, the level of GnRH increased by 2.5-4 times, and in males it decreased by an average of 3.1 times; in response to those changes in animals of both sexes in the reference group and in the main group only in females in the pituitary gland the level of LH increased by 1.3-1.6 times, however a decrease in FSH in all groups was more pronounced in females: by 7.8-13.7 times and less pronounced in males: by 1.4-1.7 times (р˂0, 05). In the gonads of females, the level of E2 increased, but the levels of T and P4 decreased, while P4 increased in males. Blood parameters did not reflect hormonal changes in the organs. Conclusion. Abnormalities in the HHG axis performance, along with primary immunodeficiency, play a decisive role in overcoming antitumor protection for uncharacteristic malignant tumors.
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Effect of COVID-19 pandemic: tourism and hospitality industry
Статья научная
The coronavirus, which causes COVID-19 disease, has unimaginably affected every industry. Among all industries, the tourism and hospitality industry is considered the worst-hit industry, contributing 9% of India’s total GDP; this paper presents an overview of the Indian tourism and hospitality industry before COVID-19. While sending out survey forms, we included general questions like gender, occupation, age, level of education, yearly income, what used to be their choice of location for a holiday before COVID-19, how much they yearly spent on holiday, how they plan their holiday trip, to understand the basic details and reliability of participants, also we did not ask the name of a participant to maintain the anonymity and privacy of a participant, which helped us to get an accurate data. How customers’ changed mindsets different priorities forced the tourism and hospitality industry to change the way of providing service also how the changed time has forced businesses to look for other opportunities to survive in the industry, Moreover here we have test different Sanitization and safety measurements using Friedman test to understand what are the factors that can affect the business of tourism and hospitality industry after the COVID-19 pandemic, as observed by Assaf & Scuderi.
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Effect of diabetes type-II on eye disease and its risk factors; a logit model analysis
Статья научная
To know the effect of Diabetes type-II on Eye disease and its risk factors in a tertiary eye care hospital in Karachi. This was a cross-sectional study with retrospective data collection. The data was retrieved from January to June 2019 from the Hospital Information Management System (HIMS) software of the Institute. Non-probability purposive sampling method was used to collect data. Inclusion criteria were all the diabetics type-II patients came for routine check-ups at Diabetes Eye Department irrespective of age, gender and duration of diabetes. Statistical analysis was done using STATA version 13.0 software for windows. A total of 6090 cases were analyzed. Mean age of the participants was 51.01±10.8 years. There were 2954 (48.5%) male and 3136 (51.5%) female observed in this study. Table 1 shows the results of the binary logistic regression analysis with coefficients and their standard errors (S.E.), Wald test values, p values, odd ratios, and 95% confidence intervals for odds ratios. When all explanatory variables treat as continuous variables, we found that all variables which include age, height, random blood sugar (RBS) and duration of diabetes was statistically significant at the significance level 0.05 except weight and fasting blood sugar (FBS) for individual regression slope coefficients. This study reveals findings through binary logistics regression analysis. It indicates that there is an association found in the patients of eye disease with age, height, weight, RBS, FBS. This stated that there were some risk factors observed in these variables related to eye disease. Those who have the disease have risk factor to developed the others associated disease
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Effect of slow coronary flow on signal-averaged electrocardiogram
Статья научная
The slow flow coronary or decreased coronary TIMI flow rate is characterized by delayed pacification of coronary vessels in the absence of any evidence of obstruction coronary artery disease and is detected by coronary angiography. In the present study, we aimed to evaluate the effects of slow coronary artery flow on signal-averaged electrocardiogram (SAECG) as a possible indicator of increased risk for ventricular arrhythmias and sudden cardiac death.
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Effect of smoking on the cardiovascular system of man
Статья научная
The article presents the state of the cardiovascular system of smokers with different periods of tobacco smoking. From the results of our studies, we can conclude that smoking tobacco in men results in a significant increase in heart rate, systolic blood pressure, a significant reduction in P, PQ and QT times, an insignificant increase in diastolic blood pressure and a decrease in QRS duration.
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Статья научная
The triage system is meant to be implemented in all (Accidental & Emergency Departments) so as to help and determine the relative priority of individual patient needs. Emergency patients are to be given immediate treatment, while those with non-acute symptoms may have to wait longer (Lucke et al., 2021). Assessment process during the triage need to be balanced with the extent of patient flow, as expanding the assessment process during triage may slow down the patient flow and may lead to delay in emergency service provision (Lucke et al., 2021).Through the use of computer-generated reports, archival data records for two months from the ED of the Bahria International Hospital in Lahore, Pakistan to assess the effectiveness of patients triage flow model. The results of this quantitative study showed that the patient flow model had a considerable temporal effect. Including 16 females, 25 were male and 25% average waiting was more than 240 mints. The ability to decrease patient wait times while enhancing patients quality of care and health outcomes is one of the social change implications. A quantitative study would produce data that would assist medical staff by shortening the wait times for patients.
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Effectiveness of blockchain to solve the interoperability challenges in healthcare
Статья научная
This study aims to explore the potential of Blockchain to transform healthcare, build the patient-driven healthcare ecosystem rather than the current institutional driven and enhance the privacy, security, and interoperability of healthcare data and check the counterfeit drugs. Interview excerpts from Industry experts/developers in the field of IT and experience from the implementation of the technology in the financial world will help understand its viability in healthcare. Consulting with domain experts is a qualitative process that involves comprehending the perception of the experts. The research paper will help the healthcare sector lay down future business strategies to redefine its businesses by overcoming the increasing threat on patients’ private data and resolving complex supply chain issues. A decentralized ledger can prevent massive revenue loss due to counterfeit drugs to track and verify each drug’s movement on the unchangeable record. The primary and secondary research is original, adding its authenticity with interview excerpts of domain experts. The results of this research paper will help identify the transparency, immutability, cost-saving, and streamlining of business to be brought by Blockchain in health care. It would be the transformational journey from innovation to market the quality products to the end consumer.
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Статья научная
Pregnancy is the period of gestation from the fertilization of an egg, through development of a fetus, and ending at birth of the baby. A woman’s desire for, and cold pack of, pain relief during labour are influenced by many factors, including her expectations, the complexity of her labour and the severity of her pain. Objectives: To assess the pre-test and post-test level of pain perception during active phase of labour among parturient mothers both in experimental and control group, effectiveness of cold pack on reduction of pain perception during active phase of labour among parturient mothers in the experimental group, association between the level of pain perception during active phase of labour among parturient mothers with their selected demographic variables. Methods: An experimental research design was adopted for the study with 60 samples who met the inclusion criteria were selected by purposive sampling technique. Semi structured interview method was used to collect the demographical and obstetrical data, Wong Baker Scale tool was used to measure the level of pain. Result: The study shows that there is a significant difference between the posttest levels of pain perception during active phase of labour among parturient mothers in the experimental group than in the control group. Conclusion: There was a significant association in the post test level of pain perception among parturient mother in the experimental group than in the control group at p function show_abstract() { $('#abstract1').hide(); $('#abstract2').show(); $('#abstract_expand').hide(); }
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Статья научная
Hyper tension is often known as high blood pressure. It is a serious medical condition that raises the risk of heart attack, stroke, renal failure, and blindness. When the systolic blood pressure readings are greater than or equal to 140 millimeters of mercury and the diastolic blood pressure readings are greater than or equal to 90 millimeters of mercury on two different days, hypertension is diagnosed. It is one of the leading causes of death in the world. Of the assessed 1130000000 people who have hypertension, fewer than 1 in 5 have it under control. The main contributors to the increase in hypertension are unhealthy diets, physical inactivity.In 2025; anpredictable 1.56 billion adults will be living with hypertension.).The aim of the study is to assess the Awareness regarding Hypertension among hypertensive patient.In this study, the pre-experimental research design was accepted. The samples of the present study were patients with pre hypertension and stage -I hypertension. Conclusion: This pilot study concludes by proving the efficiency of health education on Knowledge of hypertension among rural adult hypertensive patient.
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Статья научная
Diabetic populations are anticipated to increase from 171 million to 366 million in 2030, with the greatest rates in India, China, and the United States. Diabetes is a metabolic disorder that generates high glucose levels in the blood. The World Health Organization (WHO) estimates that India has over 70 million diabetics and is on its way to become the world’s diabetes capital. Patients had a 7.20 knowledge score on the pretest and an 11.78 knowledge score on the posttest, resulting in a mean difference of 4.58 knowledge score, this is a considerable and statistically significant increase in knowledge. The relationship between the patient’s demographic characteristics and their post-test knowledge score..Patients with a high education level and longer disease duration got a higher knowledge score than those with a lower level of education and a shorter duration of illness. The chi square test and Yates corrected chi square test were used to corroborate it.
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Статья научная
Background: Kidney is a vital organ and the main function is to remove waste products and excess water from the blood. Different kidney pathogenesis challenges the function of human body and puts human life danger. Two such important pathogenesis is acute and chronic renal failure. The incidence of acute renal failure has been estimated to be 209 patients per million populations per year and 37% of patients treated in intensive care units. Muscle cramps also can occur when patients are below dry weight. The severe muscle cramping experienced near the end of the hemodialysis treatment and persisting for a time after hemodialysis often is due to dehydration. Treatment for cramping varies from unit to unit. When patients are having cramping and have low blood pressure, the staff may give normal saline. Aim of the study: The main aim of the study to assess effectiveness of isotonic exercise on muscle cramps among hemodialysis patients. Methods: Quantitative research design was adopted for the study with 60 samples which met the inclusion criteria were selected by convenience sampling technique. Demographic variables data were collected by using a multiple-choice questionnaire followed by Pretest was conducted by using muscle cramp assessment tool for both experimental group and control group. Isotonic exercise was given 10 to 15 minutes at one session for experimental group Post test was conducted by using muscle cramps assessment tool and for both experimental group and control group. Result: Out of 60 samples, The calculated student Independent ‘t’ test value of t = 2.500 was found to be statistically highly significant at p function show_abstract() { $('#abstract1').hide(); $('#abstract2').show(); $('#abstract_expand').hide(); }
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Effectiveness of modified Manchester triage flow model regarding patients’ waiting time
Статья научная
Triage is a French word meaning to sort or to choose. Triage is therefore a process whereby each patient is prioritized amongst the randomly approaching patients in the Accident & Emergency Department/rescue area for emergency care ( Zachariasse et al., 2021). Sorting of patients into priority categories is often performed by an experienced doctor/surgeon or a senior health professional/nurse. The triage nurse/health professional shall quickly assess the patient’s condition, interpret the clinical features and then exercise interventions in the early phase to prevent deterioration and death (Soler-Sanchis, Martínez-Arnau, Sánchez-Frutos, & Pérez-Ros, 2022). The objective of the triage is to defer a patient who can wait, while give priority to those who are in imminent danger, and whose life can be saved by a timely intervention (Costa, Nicolaidis, Gonçalves, Souza, & Blatt, 2020). The Manchester Triage System is used to maintain a consistent method of prioritising and assessing patients, allowing for thorough audits and improved patient safety. Emergency departments (EDs) are seeing more difficulties globally as a result of an increase in patients and an inability to adjust capacity to meet demand. This is against a background of decreasing hospital resources. Consequently, ED crowding has become a great, international phenomenon (Zachariasse et al., 2021). The Manchester Triage System is one of Europe’s most widely used triage systems, considering five levels to prioritise patients in the ED: level 1 (red), immediate; level 2 (orange), very urgent; level 3 (yellow), urgent; level 4 (green), standard; and level 5 (blue), non-urgent (Brutschin, Kogej, Schacher, Berger, & Gräff, 2021) Patient flow model refers to the movement of patients through health care settings involves the medical care, physical resources, and internal systems needed to get patients from the point of admission to the point of discharge while maintainingand patient/provider satisfaction (Tlapa et al., 2020). The major facility for urgent medical difficulties is a hospital emergency department (ED), which is a complex system with erratic demands.
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Статья научная
Non-Stress test is a non-invasive test performed over 28 week of gestation for detection of ante partum fetal surveillance. Maternal positioning can have an impact on both the mother’s and fetal physiological well-being. Objective: Assess and compare the effectiveness of maternal positions on bio physiological parameters of the fetus during NST. Methods: Quantitative quasi-experimental pretest, posttest only research design, 60 mothers were selected by random sampling technique. Maternal, fetal bio physiological parameters tool was used. The mothers were placed in left lateral, supine position while performing NST and fetal parameters were monitored and interpreted. Mother vitals also monitored. Results: The post test score of fetal reaction in supine was 4.20±1.16 and in lateral 4.90±0.31. The calculated independents’ test value of t = 3.205 was found to be statistically significant at p
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