Статьи журнала - Cardiometry
Все статьи: 606
Development of space technologies and problems of “home medicine”
Отчет
Experience of cosmonauts’ health monitoring shows that in the study of healthy subjects clinical approach to the evaluation of various medical and physiological data is almost less effective than the evaluation of organism adaptive abilities. The idea of prenosological diagnosis and the concept of adaptive risks develop in space medicine last years. These new space technologies are being actively tested in terrestrial studies in systems as "home medicine". The report presents three variants of systems, respectively, designed to work with a) home PC ("Ecosan-2007" and "Ecosan-TM"), b) Internet connections ("Delta 2013"), c) mobile communication channels ("Traffic Lights of Health"). The main method of functional conditions evaluation in all these systems is the heart rate variability (HRV) analysis. HRV indices allow us to construct a mathematical model and to compute the stress degree of regulatory systems, their functional reserve and adaptive risk.
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Development of the basilar artery system in the human embryonic period
Статья научная
The doctrine of the origin and development of cerebral arteries in the embryonic period of man in the XIX - XXI centuries was formed by I. Tandler (1899, 1902), H. Evans (1911), G.L. Streeter (1908, 1918), G.D. Aronovich (1939), D.N. Padget (1947 - 1972), N.V. Popova-Latkina (1954 - 1975), Y.N. Shapovalov (1963), A.G. Knorre (1967), I. Stanek (1977), B. Carlson (1983), A.V. Gorbunov (1998 - 2022), etc. To date, we have shown that basilar arteries are detected in embryos at 7 weeks of intrauterine development, posterior cerebral arteries with plexiform branching - at 8 weeks of intrauterine life, and persistent trigeminal arteries continue to be detected in prenatal embryos at 8-9 weeks of human prenatal ontogenesis. In prenatal embryos 7-8-9 weeks of prenatal ontogenesis, the basilar artery system provides the needs of the human intrauterine brain.
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Статья научная
Not only protozoa being the simplest organisms have a single ventricle heart. Artificial heart systems used in cardiac surgery can be also of the single-ventricle design. Besides, there is a “single-ventricle heart condition”, i.e. a complex of defects in the structure of the heart that may occur in some human individuals and that may be found with different occurrence rate and severity. This defect should be attributed to an uneven development and malformation of some individual heart segments in the prenatal period. Single Ventricle belongs to the category of congenital heart defects. The latter greatly increases the scientific interest in studying the features of mathematical models of the single-ventricle heart condition. Herein, we offer our study on some issues of the smoothness of sewing of the exact solutions of a mathematical model of a single-ventricle heart based on the equation of forced oscillations.
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Отчет
The paper reviews the existing methods for hemodynamic parameters measurement, namely the Fick method, the thermodilution technique and the Cardiocode technology. Comparative analysis of the above methods is presented. Strong and weak points in each method and their informative values are identified. Distinctive features of the Cardiocode method, as the only noninvasive one, are described.
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Diagnostics of coronary blood flow: advantages of using the cardiometric method
Статья научная
The article discusses the features of the diagnosis of coronary blood flow using the cardiometric method. Diagnosis of coronary blood flow is of great importance in cardiology. The causes of incomplete filling of the coronary arteries with blood are considered, criteria for rechecking the correctness of the diagnosis of the functioning of the coronary blood flow, including amount of lactate, stress index and type of adaptation reaction, are identified. A possible therapy for the early stage of reducing the blood filling of the coronary arteries is given.
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Другой
This paper develops three interconnected ideas about measurements of durations, of the calendar times and of the time in historical processes. It is shown that although we cannot predict ahead of time what exact novelties will arise in the noosphere, we are able to estimate a periodicity of the radical changes occurring in the cultural history.
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Статья научная
Aims: to study the features of the functioning of the hypothalamic-pituitary-gonadal axis (HPGA) regulation in male rats at the stages of liver metastasizing. Materials and methods. Our research work was performed in 30 outbred male rats. Metastases in the liver were produced by implantation of sarcoma 45 (S45) cells into the spleen, which was previously positioned under the skin. The time spans of the study are 5 weeks (the pre-metastatic stage) and 7 weeks (the metastatic stage) after tumor cell transplantation. In the tissues, the content of the following hormones was determined by RIA: luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), total testosterone (Ttot), progesterone (P4); by ELISA we determined the content of the following hormones: gonadotropin-releasing hormone (GnRH), free testosterone (Tfr) and estrone (E1). Results. At all stages of the study, the level of GnRH in the hypothalamus decreased by more than 2.0 times; in the pituitary gland, the hormone levels had multidirectional dynamics: LH decreased by 1.6 times, and FSH increased by more than 6.0 times. Liver metastases were characterized by high levels of E1 and Ttot. In the gonads, a high level of P4 was recorded and concentrations of both forms of testosterone were reduced. The concentrations of E2 (by 1.6 times), Tfr (by 4.8 times) increased in blood, and the level of Ttot decreased (by 1.9 times). The salient features of HPGA in the presence of two metastasis sites (liver and lungs) were as follows: in blood, a 2.0 times lower increase in the LH and Tfr contents, a 1.6 times greater increase in E2, an increase in P4 (2.6 times), 1, 4 times lower level of FSH; in the gonads, there are found lower levels of P4, E1, but higher levels of Tfr and Ttot; in liver metastases, a greater increase in P4 (5.2 times), E1 (2.2 times) and Tfr (2.0 times) is recorded. Conclusion. Metastasizing to the liver was accompanied by activation of HPGA with the maximum accumulation of reactogenic E1 in liver metastases in rats with two metastasis sites that may indicate their more severe malignancy and ability to metastasize to the lungs.
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Digital heart rate diagnostics
Отчет
Heart rate diagnostics based on tactile sensations has been known for over 5 thousand years. Medieval doctors used it and modern doctors use it. With the advent of the Marei arteriograph in 1860, heart rate waves became possible to observe, creating visual images, and subsequently analyze them using a computer in digital form. However, in this way, the main obstacle remains the imperfection of the sensors, allowing you to receive only weak and noisy signals with a large number of artifacts. In practice, heart rate wave sensors are produced only by Millar (USA), Omron (Japan), and the Institute of Mechanical Engineering of the Russian Academy of Sciences (RF). This article summarizes the experience of studying heart rate waves by IMASH RAS since 1990. Systematization of the results led to an attempt to create the basis of digital heart rate diagnostics, which will make it easier for doctors to make a diagnosis based on methods of modern information technologies.
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Discovery of adaptational reactions: a new milestone in the development of oncology
Статья
The celebration of the 90th anniversary of the National Medical Research Centre for Oncology at the Ministry of Health of the Russian Federation in the past 2021 expanded its time frame due to other anniversaries that are inextricably linked with the scientific activities of the Rostov Cancer Centre.
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Статья научная
Aims: to study the content of regulatory peptides in the hypothalamus and pituitary gland, as well as sex steroids in the gonads in rats of both sexes with Guerin’s carcinoma against the background of hypothyroidism. Materials and methods. Our experiment was performed in white outbred rats of both sexes with induced hypothyroidism, against the background of which Guerin’s carcinoma was transplanted. In 1% homogenates of the pituitary and the hypothalamus and in 10% homogenates of the gonads in the animals from the main and reference groups, the levels of GnRH (Casabio, China) were determined by the ELISA method using standard kits, and the content of LH, FSH, estradiol (E2), testosterone (T) and progesterone (P4) by the RIA method (Immunotech, Czech Republic). Statistical analysis of the results was performed using the Statistica 10.0 software package. Results. In females of the main group, the level of GnRH in the hypothalamus increased by 1.6 times, but the content of LH and FSH in the pituitary gland decreased, while in males the content of GnRH decreased by 1.4 times and FSH by 1.6 times compared with the intact animals. In the gonads of females of the main group, the content of E2 and T decreased by 1.3 times, but the level of P4 increased by 4.7 times, while in males the T production decreased by 7.1 times. Hypothyroidism, against the background of which Guerin’s carcinoma developed, had a significant effect both on the central links of the HPG axis and the peripheral ones, producing an additional hormonal imbalance in sex steroids
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Статья научная
Aims The aim hereof is to study the cardiovascular system disorders in the early post-castration period in patients with locally advanced cervical cancer and a possibility of correction of such disorders with the low-dose xenon therapy
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Статья
The creation of injectable bone cements (BC) remains a pressing issue in modern biomaterial science due to the prospects for their use in minimally invasive surgical interventions in onco-orthopedics for replacing bone defects in patients that occur after removal of primary or metastatic spinal tumors.
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Ред. заметка
The offered noninvasive device and technology CARDIOCODE (www.cardiocode.ru, www.cardiometry.net) are capable of delivering data on any changes in the performance of the cardiovascular system and tracing development of any processes that may occur in the heart and blood vessel system, and all that in a very simple and most accurate way.
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E-learning in formal education under forced conditions using SDT and tam
Статья научная
This study aims to understand the students’ attitude towards e-learning under the forced environment of the COVID-19 pandemic. This study gives a fresh insight into e-learning, considering the lack of comprehensive research on the influencing variables that impact the user acceptance of e-learning by learners in the Indian Universities during COVID-19 pandemic. The rational model has been constituted based on the Technological Acceptance Model (TAM) and Self-Determination Theory (SDT) to study the effective influence of Autonomy, Relatedness & Competency on the construct of TAM. The result showed significant relations of the self-determination variables with perceived ease of use & perceived usefulness, which further helps us establish a relationship between intrinsic & extrinsic factors of SDT framework with attitude and satisfaction level of Indian University students towards e-learning. This study will assist in bridging the gap between the understanding of organizations and actual factors impacting students’ learning process during the pandemic of COVID-19.
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ECG as a quest for extracting new data: non-invasive measurement of acid-alkaline parameters
Статья научная
Aims A cardiac muscle performance assessment in terms of acid-alkaline balance has never been carried out before. The studies show it is possible to evaluate indirectly aerobic, anaerobic and phosphocreatine processes in the cardiac muscle using ECG only. The aim is to study the capabilities of acid-alkaline balance measurement in the cardiac muscle using ECG only, in combination with the heart cycle phase analysis. Materials and methods The ECG of the ascending aorta is recorded with Cardiocode device. Amplitudes of the derivatives of leading and trailing edge of R, L and j waves are measured. The QRS complex amplitude depends on the amplitudes of the septum and myocardium muscles contractions. The septum is contracted because of the lesser resistance since the myocardium muscles are not loaded yet. When the myocardium muscles are contracted, they take a heavier load since the septum remains under static strain. It allows evaluating the difference in the energy consumption for each group of the muscles according to the respective ECG derivative...
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ECG periodic table: a new ECG classification based on heart cycle phase analysis
Статья научная
Aims The article considers the development of the periodic table of ECG phase changes which should reflect the variety of the ECG curves and can be used as reference system for diagnostics purposes. Materials and methods More than 5,000 ECG records were studied. They were recorded as original single-lead ECG of the ascending aorta. This fundamentally new ECG lead system reflects all processes in cardiovascular system. It was named by its developers the “ECG – HDA”. Basing on the theory of cardiac cycle phase analysis, the authors defined deviations from the normal ECG curve. Clinical tests were conducted and descriptions based on the laws of cardiometry were provided. Results A fundamentally new system of the ECG curve evaluation has been developed. Conclusion It is stated that all the variety of the actual ECG curves can be divided into 10 groups. Each group contains 4 levels of characteristic changes, starting from the norm up to and including critical deviations from the norm. The results are presented in the “ECG phase changes periodic table”. The table can be used for very precise diagnostics. The periodic table enables assessing the capabilities of the practical application of electrocardiography from a new point of view.
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Effecacy of antisense oligonucleotide HUSH-11 with thiophosphate in treatment of melanoma in mice
Статья
Melanoma is one of the highly aggressive cancer diseases. Melanoma accounts for about 2% of the total cancer incidence in Russia. In a large number of cases, melanoma shows its potential to metastasize and becomes a cause of death. Aims. Our research team focused on the design and development of an anti-melanoma drug based on antisense oligonucleotides (ASOs) with thiophosphate for the use both in the postsurgery treatment and the targeted therapy.
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Статья научная
The aim was to study changes in the functioning of the hypothalamic-pituitary-gonadal (HPG) axis in BALB/c Nude mice of both sexes with multiple primary malignant tumors (MPMTs). The BALB/c Nude mice (n=84) of both sexes were divided into groups as follows: intact males and females (n=14), a reference group of mice of both sexes with standard subcutaneous inoculation of B16/F10 melanoma (n=14); the main group of mice with the reproduction of the MPMT model (n=14); B16/ F10 melanoma and Lewis carcinoma were inoculated into mice sequentially subcutaneously on two sides: one on the left side and the other on the right side. After 15 days of the growth of the malignant tumors, GnRH, LH and FSH contents were determined by ELISA using standard kits in 1% of the homogenates of the hypothalamic and pituitary tissues, and estradiol content (E2) was determined in 10% homogenates of ovaries and testes, as well concentrations of testosterone (T) and progesterone (P4) were identified in blood serum with the standard RIA kits (Immunotech, Czech Republic). Results. In the hypothalamus in females of the reference and main groups, the level of GnRH increased by 2.5-4 times, and in males it decreased by an average of 3.1 times; in response to those changes in animals of both sexes in the reference group and in the main group only in females in the pituitary gland the level of LH increased by 1.3-1.6 times, however a decrease in FSH in all groups was more pronounced in females: by 7.8-13.7 times and less pronounced in males: by 1.4-1.7 times (р˂0, 05). In the gonads of females, the level of E2 increased, but the levels of T and P4 decreased, while P4 increased in males. Blood parameters did not reflect hormonal changes in the organs. Conclusion. Abnormalities in the HHG axis performance, along with primary immunodeficiency, play a decisive role in overcoming antitumor protection for uncharacteristic malignant tumors.
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Effect of COVID-19 pandemic: tourism and hospitality industry
Статья научная
The coronavirus, which causes COVID-19 disease, has unimaginably affected every industry. Among all industries, the tourism and hospitality industry is considered the worst-hit industry, contributing 9% of India’s total GDP; this paper presents an overview of the Indian tourism and hospitality industry before COVID-19. While sending out survey forms, we included general questions like gender, occupation, age, level of education, yearly income, what used to be their choice of location for a holiday before COVID-19, how much they yearly spent on holiday, how they plan their holiday trip, to understand the basic details and reliability of participants, also we did not ask the name of a participant to maintain the anonymity and privacy of a participant, which helped us to get an accurate data. How customers’ changed mindsets different priorities forced the tourism and hospitality industry to change the way of providing service also how the changed time has forced businesses to look for other opportunities to survive in the industry, Moreover here we have test different Sanitization and safety measurements using Friedman test to understand what are the factors that can affect the business of tourism and hospitality industry after the COVID-19 pandemic, as observed by Assaf & Scuderi.
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Effect of diabetes type-II on eye disease and its risk factors; a logit model analysis
Статья научная
To know the effect of Diabetes type-II on Eye disease and its risk factors in a tertiary eye care hospital in Karachi. This was a cross-sectional study with retrospective data collection. The data was retrieved from January to June 2019 from the Hospital Information Management System (HIMS) software of the Institute. Non-probability purposive sampling method was used to collect data. Inclusion criteria were all the diabetics type-II patients came for routine check-ups at Diabetes Eye Department irrespective of age, gender and duration of diabetes. Statistical analysis was done using STATA version 13.0 software for windows. A total of 6090 cases were analyzed. Mean age of the participants was 51.01±10.8 years. There were 2954 (48.5%) male and 3136 (51.5%) female observed in this study. Table 1 shows the results of the binary logistic regression analysis with coefficients and their standard errors (S.E.), Wald test values, p values, odd ratios, and 95% confidence intervals for odds ratios. When all explanatory variables treat as continuous variables, we found that all variables which include age, height, random blood sugar (RBS) and duration of diabetes was statistically significant at the significance level 0.05 except weight and fasting blood sugar (FBS) for individual regression slope coefficients. This study reveals findings through binary logistics regression analysis. It indicates that there is an association found in the patients of eye disease with age, height, weight, RBS, FBS. This stated that there were some risk factors observed in these variables related to eye disease. Those who have the disease have risk factor to developed the others associated disease
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